Bianka SiewertBianka SIEWERT, Dr.
Postdoctoral Researcher

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.050
6020 Innsbruck / Austria

Phone: +43 512 507 - 58413 | Fax: +43 512 507 - 58499
Email: bianka.siewert@uibk.ac.at

Research
Publications
Teaching
Publication List

Publications (first authors underlined)

Siewert, B.; Rixel, V.H.S; Rooden, E.J.; Hopkins, S.L.; Moester, J.B.; Ariese, F.; Siegler, M.A.; Bonnet, S.; Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces Cell Death via two different Mechanisms"; Chemistry a European Journal, 2016, 22, 10960; DOI: 10.1002/chem.201600927

Rixel, V.H.S; Siewert, B.; Hopkins, S.L; Askes, S.; Buseman, A.; Siegler, M.A.; Bonnet, S.; Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites, Chemical Science, 2016, 7, 4922-4929; DOI: 10.1039/C5PP00424A.

Hopkins, S. L.; Siewert, B.; Askes, S. H. C.; van Veldhuizen, P.; Zwier, R.; Heger, M.; Bonnet, S.; In vitro cell irradiation protocol for testing photopharmaceuticals and the effect of blue, green, and red light on human cancer cell lines, Photochemical & Photobiological Sciences, 2016,

Heller, L.; Sommerwerk, S.; Tzschöckell, F.; Wiemann, J.; Schwarz, S.; Siewert, B.; Al-Harrasi, A.; Csuk, R.; First Occurence of a Furano-glycyrrhetinoate and its cytotoxicity, Archiv der Pharmazie, 2015, 348(12), 889-96.

Schwarz, S.; Loesche, A.; Lucas, SD; Sommerwerk, S.; Serbian, I; Siewert, B.; Pianowski, E.; Csuk, R.; Converting maslinic acid into an effective inhibitor of acyclcholinesterases, European Journal of Medicinal Chemistry, 2015, 103, 438-445.

Sommerwerk, S.; Heller, L.; Siewert, B.; Csuk, R.; Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues, Bioorganic & Medicinal Chemistry, 2015, 23 (17), 5595-602.

Heller, L; Schwarz, S; Perl, V.; Köwitsch, A.; Siewert, B.; Cusk, R.; Incorporation of a Michael acceptor enhances the antitumor activity of triterpenoic acids, European Journal of Medicinal Chemistry., 2015, 101, 391-9.

Schwarz, S.; Siewert, B.; Csuk, R.; Rauter, A.P.; New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest, European Journal of Medicinal Chemistry., 2015, 90, 595-602.

Csuk, R.; Heller, L.; Siewert, B.; Gutnov, A.; Seidelmann, O.; Wendisch V.; β-Nitro substituted carboxylic acids and their cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 4011-4013.

Siewert, B.; van Rixel, V.H.S; Bahreman, A.; Higgins, S.L.H; Heger, M.; Askes, S., Bonnet, S.; Biological evaluation of light-activatable ruthenium-based anticancer prodrugs; JBIC Journal of Biological Inorganic Chemistry, 19, S784. 

Siewert, B.; Csuk, R.; Membrane damaging activity of a maslinic acid analog, European Journal of Medicinal Chemistry, 2014, 74, 1-6.

Schwarz, S.; Siewert, B.; Xavier, N.M.; Jesus, A.R.; Rauter, A.P.; Csuk, R.; A “natural” approach: Synthesis and cytotoxicity of monodesmosidic glycyrrhetinic acid glycosides, European Journal of Medicinal Chemistry, 2014, 72, 78-83.

Siewert, B.; Wiemann, J.; Köwitsch, A.; The chemical and biological potential of C ring modified triterpenoids, European Journal of Medicinal Chemistry, 2014, 72, 84-101.

Siewert, B.; Pianowski, E., Obernauer, A., Csuk, R., Towards cytotoxic and selective derivatives of maslinic acid, Bioorganic & Medicinal Chemistry, 2014, 22, 594-615.

Siewert, B.; Pianowski, E.; Csuk, R., Esters and amides of maslinic acid trigger apoptosis in human tumor cells and alter their mode of action with respect to the substitution pattern at C-28, European Journal of Medicinal Chemistry, 2013, 23, 3542-3546.

Csuk, R.; Albert, S.; Siewert, B.; Synthesis and radical scavenging activities of resveratrol analogs, Archiv der Pharmazie , 2013, 346(7):504-10; doi: 10.1002/ardp.201300081

Csuk, R; Siewert, B; Wiemann, J., A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 3542-3546.

Csuk, R.; Sczepek, R.; Siewert, B.; Nitsche, C., Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis, Bioorganic & Medicinal Chemistry, 2013, 21, 425-435.

Csuk, R.; Nitsche, C.; Sczepek, R.; Schwarz, S.; Siewert, B., Synthesis of Antitumor-Active Betulinic Acid-Derived Hydroxypropargylamines by Copper-Catalyzend Mannich Reactions. Archiv der Pharmazie (Weinheim) 2013.

Csuk, R.; Stark, S.; Nitsche, C.; Barthel, A.; Siewert, B., Alkylidene branched lupane derivatives: Synthesis and antitumor activity, European Journal of Medicinal Chemistry, 2012, 53, 337-345.

Csuk, R.; Sommerwerk, S.; Wiese, J.; Wagner, C.; Siewert, B.; Kluge, R.; Stroehl, D., Isolation, structure, synthesis and cytotoxicity of an unprecedented flupirtine dimer, Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2012, 67, 1297-1304.

Csuk, R.; Siewert, B.; Dressel, C.; Schaefer, R., Tormentic acid derivatives: Synthesis and apoptotic activity, European Journal of Medicinal Chemistry, 2012, 56, 237-245.

Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Conversions at C-30 of Glycyrrhetinic Acid and Their Impact on Antitumor Activity. Archiv der Pharmazie, 2012, 345, 223-230.

Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids. Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2012, 67, 731-746.

Csuk, R.; Heinold, A.; Siewert, B.; Schwarz, S.; Barthel, A.; Kluge, R.; Ströhl, D., Synthesis and Biological Evaluation of Antitumor-Active Arglabin Derivatives, Archiv der Pharmazie, 2012, 345, 1001.

Csuk, R.; Albert, S.; Siewert, B.; Schwarz, S., Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents, European Journal of Medicinal Chemistry, 2012, 54, 669-678.

Csuk, R.; Siewert, B., A convenient separation of ursolic and oleanolic acid, Tetrahedron Letters, 2011, 52, 6616-6618.

Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and antitumor activity of ring A-modified glycyrrhetinic acid derivatives, Zeitschrift für Naturforschung B - A Journal of Chemical Sciences, 2011, 66, 521-532.

Csuk, R.; Schwarz, S.; Siewert, B.; Kluge, R.; Ströhl, D., Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives, European Journal of Medicinal Chemistry, 2011, 46, 5356-5369.

Albert, S.; Horbach, R.; Deising, H. B.; Siewert, B.; Csuk, R., Synthesis and antimicrobial activity of (E) stilbene derivatives, Bioorganic & Medicinal Chemistry, 2011, 19, 5155-5166.

Csuk, R.; Barthel, A.; Sczepek, R.; Siewert, B.; Schwarz, S., Synthesis, Encapsulation and Antitumor Activity of New Betulin Derivatives, Archiv der Pharmazie, 2011, 344, 37-49.

top


top

Nach oben scrollen