Stefan SchwaigerStefan SCHWAIGER, Mag. pharm. Dr.
Research Associate

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.042
6020 Innsbruck / Austria

Phone: +43 512 507 - 58409 | Fax: +43 512 507 - 58499
Email: stefan.schwaiger@uibk.ac.at

 

Research
Publications
Teaching
Publication List

Original Papers  |  Patents  |  Oral presentations


PhD Thesis

Schwaiger, S. (2005): Phytochemical, Pharmacological and Analytical Investigations of Edelweiss (Leontopodium alpinum Cass.) and related species. Leopold-Franzens-Universität Innsbruck, 95 S. 

 

Original Papers (2008 - 2013)

  1. Enthammer, M., Papadakis, E.S., Gachet, M.S., Deutsch, M., Schwaiger, S., Koziel, K., Ashraf, M.I., Khalid, S., Wolber, G., Packham, G., Cutress, R.I., Stuppner, H., Troppmair, J., (2013): Isolation of a Novel Thioflavin S-Derived Compound that Inhibits BAG-1-Mediated Protein Interactions and Targets BRAF Inhibitor-Resistant Cell Lines. Mol Cancer Ther; Published OnlineFirst September 18, 2013; doi:10.1158/1535-7163.MCT-13-0142.

  2. Kuehnl S., Schroecksnadel S., Temml V., Gostner J.M., Schennach H., Schuster D., Schwaiger S., Rollinger J.M., Fuchs D., Stuppner H., (2013): Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. Phytomedicine : international journal of phytotherapy and phytopharmacology. http://dx.doi.org/10.1016/j.phymed.2013.06.006.

  3. Messner, B., Kern, J., Wiedemann, D., Schwaiger, S., Tuerkcan, A., Ploner, C., Trockenbacher, A., Aumayr, K., Bonaros, N., Laufer, G., Stuppner, H., Untergasser, G., Bernhard, D., (2013): 5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo. PLoS One, 8(3), e58342.

  4. Atanasov, A.G, Wang, J.N., Gu, S.P., Bu, Ji., Kramer, M.P., Baumgartner, L., Fakhrudin, N., Ladurner, A., Malainer, C., Vuorinen, A., Noha, S.M., Schwaiger, S., Rollinger, J.M., Schuster, D., Stuppner, H., Dirsch, V.M., Heiss, E.H., (2013): Honokiol: A non-adipogenic PPARγ agonist from nature. Biochimica et biophysica acta, 1830(10), 4813-4819.

  5. Ladurner, A., Atanasov, A.G., Heiss, E.H.; Baumgartner, L., Schwaiger, S., Rollinger, J.M., Stuppner, H., Dirsch, V.M., (2012): 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells. Biochemical Pharmacology, 84(6), 804-812.

  6. Cicek, S.S., Untersulzner, C., Schwaiger, S., Zidorn, C., (2012): Caffeoyl-D-glucaric acid derivatives in the genus Gnaphalium (Asteraceae: Gnaphalieae). Records of Natural Products, 6(3), 311-315.

  7. Remias, D., Schwaiger, S., Aigner, S., Leya, T., Stuppner, H., Luetz, C., (2012): Characterization of an UV- and VIS-absorbing, purpurogallin-derived secondary pigment new to algae and highly abundant in Mesotaenium berggrenii (Zygnematophyceae, Chlorophyta), an extremophyte living on glaciers. FEMS Microbiology Ecology, 79(3), 638-648.

  8. Ganzera, M., Greifeneder, V., Schwaiger, S., Stuppner, H., (2012): Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography. Fitoterapia, 83(8), 1680-1686.

  9. Zeller I., Wiedemann D., Schwaiger S., Stelzmuller M., Kreutmayer S., Leberfing O., Stuppner H., Bernhard D., (2012): Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 42(5), 878-84.

  10. Heiss, E.H., Baumgartner, L., Schwaiger, S., Heredia, R.J., Atanasov, A.G., Rollinger, J.M., Stuppner, H., Dirsch, V.M., (2012): Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor. Planta Medica, 78(7), 678-681.

  11. Schwaiger, S., Zeller, I., Poelzelbauer, P., Frotschnig, S., Laufer, G., Messner, B., Pieri, V., Stuppner, H., Bernhard, D., (2011): Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). Journal of Ethnopharmacology, 133(2), 704-709.

  12. Duwensee, K., Schwaiger, S., Tancevski, I., Eller, K., van Eck, M., Markt, P., Linder, T., Stanzl, U., Ritsch, A., Patsch, J.R., Schuster, D., Stuppner, H., Bernhard, D., Eller, P., (2011): Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Atherosclerosis, 219(1), 109-115.

  13. Baumgartner, L., Schwaiger, S., Stuppner, H. (2011):Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC-PDA and HPLC-MS. Journal of Pharmaceutical and Biomedical Analysis, 56(3), 546-552.

  14. Baumgartner, L., Sosa, S., Atanasov, A.G., Bodensieck, A., Fakhrudin, N., Bauer, J., Del Favero, G., Ponti, C., Heiss, E.H., Schwaiger, S., Ladurner, A., Widowitz, U., Della Loggia, R., Rollinger, JM., Werz, O., Bauer, R., Dirsch, VM., Tubaro, A., Stuppner, H. (2011): Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro. Journal of Natural Products, 74(8), 1779-1786.

  15. Safer, S., Cicek, SS., Pieri, V., Schwaiger, S., Schneider, P., Wissemann, V., Stuppner, H. (2011): Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of 1H NMR and HPLC-ESI-MS. Phytochemistry (2011), 72(11-12), 1379-1389.

  16. Schwaiger, S., Zeller, I., Pölzelbauer, P., Frotschnig, S., Laufer, G., Messner, B., Pieri, V., Stuppner, H., Bernhard, D. (2011): Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). Journal of Ethnopharmacology 133, 704–709.

  17. Antal, D.S., Schwaiger, S., Ellmerer-Müller, E.P., Stuppner, H. (2010): Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents. Planta medica 76(15), 1765 - 1772.

  18. Cicek, S.S., Schwaiger, S., Ellmerer, E.P., Stuppner, H. (2010): Development of a fast and convenient method for the isolation of triterpene saponins from Actaea racemosa by high-speed countercurrent chromatography coupled with evaporative light scattering detection. Planta Medica 76(5), 467 – 473.

  19. Schwaiger, S., Hehenberger, S., Ellmerer, E.P., Stuppner, H. (2010): A new Bisabolane Derivative of Leontopodium andersonii. Natural Product Communications 5(5), 667 – 668.

  20. Costa, S., Schwaiger, S., Cervellati, R., Stuppner, H., Speroni, E., Guerra, C. M. (2009): In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. Journal of Applied Toxicology 29(1), 7 – 14.

  21. Pieri V., Schwaiger, S., Ellmerer, E.P., Stuppner, H. (2009): Iridoid Glycosides from the Leaves of Sambucus ebulus. Journal of Natural Products 72(10), 1798 – 1803.

  22. Reisinger, U., Schwaiger, S., Zeller, I., Messner, B., Stigler, R., Wiedemann, D., Mayr, T., Seger C., Schachner, T., Dirsch, V.M., Vollmar, A.M., Bonatti, J.O., Stuppner H., Laufer G., Bernhard, D. (2009): Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts. Cardiovascular research 82(3), 542 – 549.

  23. Rollinger, J.M., Schuster, D., Danzl, B., Schwaiger, S., Markt, P., Schmidtke, M., Gertsch, J., Raduner, S., Wolber, G., Langer, T., Stuppner, H. (2009): In silico Target Fishing for Rationalized Ligand Discovery Exemplified on Constituents of Ruta graveolens. Planta Medica 75(3), 195 – 204.

  24. Hornick, A., Schwaiger, S., Rollinger, J.M., Phung Vo, N., Prast, H., Stuppner, H. (2008): Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties. Biochemical Pharmacology 76(2), 236 – 248.

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Patents

  1. Bernhard, D., Schwaiger, S., Stuppner, H., (2011): Natural extract of parts of Sambucus for use in the treatment of inflammatory processes, intimal hyperplasia and vein graft disease. PCT Int. Appl. (2011), WO 2011144639 A1 20111124.

  2. Bernhard, D., Stuppner, H., Schwaiger, S., Wiedemann, D., Untergasser, G. (2011): Pharmaceutical compositions comprising lignans and their derivatives for the medical management of angiogenesis and hypovascularity. PCT Int. Appl., 71pp. CODEN: PIXXD2 WO 2011089161 A1 20110728.

  3. Stuppner, H., Schwaiger, S., Bernhard, D., Laufer, G. (2010): Pharmaceutical compositions comprising lignans from Edelweiss and their derivatives for treating hyperplastic diseases. PCT Int. Appl. 71pp. CODEN: PIXXD2 WO 2010007169 A1 20100121.

  4. Prast, H., Rollinger, J., Schwaiger, S., Stuppner, H. (2007) Use of extracts and constituents of Leontopodium as enhancers of cholinergic function. PCT Int. Appl. CODEN: PIXXD2 WO 2007006492 A1 20070118.

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Oral presentations

  • Schwaiger, S., Sturm, S., Seger, C., Ellmere E.P., Stuppner, H. (2005): Isolation, Identification and Quantification of Phenolic Constituents of Edelweiss (Leontopodium alpinum Cass.). Lecture at the Young scientist symposium at the 53rd annual meeting of the society for medicinal plant research (GA), August 21st-25th, 2005, Florence, Italy.

  • Schwaiger S., Seger C., Godejohann M., Humpfer E., Hehenberger S., Tseng L.H., Ellmerer E.P., Spraul M., and Stuppner H. (2006): Different strategies for discriminator identification in a NMR based metabonomics matrix of the genus Leontopodium using LC-SPE-NMR, 1H-NMR-guided isolation and classical phytochemistry. Short lecture S036 at the 54 rd annual meeting of the society for medicinal plant research (GA), August 29th - September 2nd, 2006, Helsinki, Finland. Abstract in Planta med. 2006: 72(11), 975.

  • Schwaiger, S.; Schmieder, A.; Csordas, A.; Backovic, A.; Messner, B.; Wick, G.; Stuppner, H.; Bernhard, D. (2007): Isogentisin – Eine Verbindung zur Prävention Zigarettenrauch-induzierter Endothelschäden,  DPhG-ÖPhG-GA Jahrestagung, 10.-13.Oktober 2007, Erlangen, Germany.

  • Schwaiger, S; Sturm, S.; Deltedesco, I.; Schneider, P.; Stuppner, H. (2009): Determination of additional leontopodic acid derivates from Edelweiss (Leontopodium alpinum Cass.) by LC-SPE-NMR, Plants from High Altitude - Phytochemistry and Bioactivity. A Joint Symposium of the Phytochemical Society of Europe (PSE) and the Austrian Pharmaceutical Society (ÖPhG), Obergurgl/Tyrol, Austria, 26 – 29 April 2009.

  • Schwaiger, S. Reisinger, U.; Zeller, I.; Laufer, G.; Stuppner, H.; Bernhard, D.(2009): Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts, LIFE SCIENCE Meeting, September 18-19, 2009, Igls, Austria.

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