Solveigh KoeberleSolveigh KOEBERLE, Dr.
Senior Lecturer

Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.032
6020 Innsbruck / Austria

Phone: +43 512 507 - 58404 | Fax: +43 512 507 - 58499


Publication List

Wolfram T, Weidenbach, LM, Adolf J., Schwarz, M., Schädel P, Gollowitzer A, Werz O, Koeberle A, Kipp A and Koeberle SC* (2021) The trace element selenium is important for redox signaling in phorbol ester differentiated THP-1 macrophages. Int J Mol Sci (IF: 5.9). DOI: 3390/ijms222011060. * Corresponding Author

Koeberle SC, Gollowitzer A, Laoukili J, Kranenburg O, Werz O, Koeberle A and Kipp AP (2020) Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms. Redox Biol. (IF: 11.8). DOI: 10.1016/j.redox.2019.101388.

Koeberle SC, Kipp AP (2018). Selenium and inflammatory mediators. In: ‘Selenium’, Bernhard Michalke (Ed.) Molecular and Integrative Toxicology. DOI:10.1007/978-3-319-95390-8_7. INVITED REVIEW/BOOK CHAPTER

Bertz, M, Kühn, K, Koeberle, SC, Müller, MF, Hoelzer, D, Thies, K, Deubel, S, Thierbach, R, Kipp, AP (2018) Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. Free Radic Biol Med (IF: 6.0). DOI: 10.1016/j.freeradbiomed.2018.01.010.

Koeberle SC, Shinji T, Kuriu, T, Iwasaki H, Koeberle A, Schulz A, Helbing D, Yamagata Y, Morrison H, Okabe S (2017) Developmental stage-dependent regulation of spine formation by calcium calmodulin dependent protein kinase IIα and Rap1. Sci Rep, (IF: 4.8). DOI:  10.1038/s41598-017-13728-y.

Pein H, Koeberle SC*, Voelkel M, Schneider F, Rossi A, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J (IF: 5.5). *shared first authorship. DOI: 10.1096/fj.201700078R.

Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O (2015) Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J, 29, 2439-2449 (IF: 5.5). DOI: 1096/fj.14-268474. Peer reviewed

Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O (2013) Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. PNAS, 110 (7), 2546-2551 (IF: 10.7). DOI: 10.1073/pnas.1216182110.

Fischer S, Wentsch HK, Mayer-Wrangowski SC, Zimmermann M, Bauer SM, Storch K, Niess R, Koeberle SC, Grütter C, Boeckler FM, Rauh D, Laufer SA (2013) Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J Med Chem, 56 (1), 241-253 (IF: 5.5). DOI: 1021/jm301539x.

Koeberle SC, Fischer S, Schollmeyer D, Schattel V, Grütter C, Rauh D, Laufer SA (2012) Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem, 55 (12), 5868-5877 (IF: 5.4). DOI: 10.1021/jm300327h.

Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA (2011) Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol, 8, 141-3 (IF: 16.1). DOI: 10.1038/nchembio.761. Peer reviewed

Fischer S, Koeberle SC, Laufer SA (2011) p38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011). Expert Opin Ther Pat, 21, 1843-66 (IF: 2.1). DOI: 10.1517/13543776.2011.636737.

Karcher SC and Laufer, SA (2009) Successful structure-based design of recent p38 MAP kinase inhibitors. Curr Top Med Chem, 9, 655-676 (IF: 4.3). doi: 10.2174/156802609789007363

Karcher SC and Laufer SA (2009) Aza-analogue dibenzepinone scaffolds as p38 MAP kinase inhibitors: Design, synthesis and biological data of inhibitors with improved physico­chemical properties. J Med Chem, 52, 1778-1782 (IF: 5.2). DOI: 10.1021/jm801291f.

Laufer SA, Ahrens GM, Karcher SC, Hering JS, Niess R. (2006) Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP kinase inhibitors. J Med Chem, 49 (26), 7912-7915 (IF: 5.1). DOI: 10.1021/jm061072p.


Oral Presentations


„Glutathione peroxidases 1 and 2 as promising targets in anti-inflammatory therapy”.

European Federation of Pharmaceutical Science 2021 (EUFEPS Meeting 2021), ONLINE


“Glutathione peroxidases – Novel targets of anti-inflammatory drugs?” Frontiers in Medicinal Chemistry 2021, ONLINE


“Impact of the trace element selenium on macrophages during differentiation”.

58. Scientific Congress of the German Society of Nutrition (DGE Meeting 2021), ONLINE


“Selenoproteins in redox-dependent inflammatory signaling”.

Presentation series „Current research results in Pharmacy“

University of Innsbruck (Austria), ONLINE


“Forgotten neuronal signaling mechanisms: Importance of contact-dependent processes in brain development”

Leibniz Institute on Aging in Jena (Germany)


“What is the role of the tumor suppressor gene NF2 in the brain during development?”

Leibniz Institute on Aging Evaluation in Jena (Germany)


“The role of CaMKIIα activity in spine formation and morphology during development”.

Leibniz Institute on Aging in Jena (Germany), INVITED TALK


“Role of CaMKIIalpha activity in spine formation and dendritic arborisation during development”.

Joint Workshop at the University of Tokyo (Japan)


“Synthese und biologische Testung neuer aza-analoger und disubstituierter Dibenzepinone als Hemmstoffe der p38 MAP Kinase von Dibenzosuberonderivaten als allosterische p38-MAP-Kinase Inhibitoren”.

University of Tuebingen (Germany)


“Synthese von Dibenzosuberonderivaten als allosterische p38 MAP Kinase Inhibitoren”.

University of Tuebingen (Germany)


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