Solveigh KoeberleSolveigh KOEBERLE, Dr.
Senior Lecturer

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.023 
6020 Innsbruck / Austria

Phone: +43 512 507 - 58404 | Fax: +43 512 507 - 58499
Email: solveigh.koeberle@uibk.ac.at

 

Research
Publications
Teaching
 Biography
Publication List

Koeberle SC, Gollowitzer A, Laoukilic J, Kranenburg O, Werz O, Koeberle A, Kipp AP (2019) Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms. Redox Biol (IF 7.79); 
DOI: 10.1016/j.redox.2019.101388

Koeberle SC, Kipp AP (2018). Selenium and inflammatory mediators. In: ‘Selenium’, Bernhard Michalke (Ed.) Molecular and Integrative Toxicology; ISBN-10: 3-030-07026-3 / 3030070263

Bertz, M, Kühn, K, Koeberle, SC, Müller, MF, Hoelzer, D, Thies, K, Deubel, S, Thierbach, R, Kipp, AP (2018) Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. Free Radic Biol Med (IF: 6.0); DOI: 10.1016/j.freeradbiomed.2018.01.010

Koeberle SC, Shinji T, Kuriu, T, Iwasaki H, Koeberle A, Schulz A, Helbing D, Yamagata Y, Morrison H, Okabe S (2017) Developmental stage-dependent regulation of spine formation by calcium calmodulin dependent protein kinase IIα and Rap1. Sci Rep, (IF: 4.8); DOI:  10.1038/s41598-017-13728-y

Pein, H, Koeberle, SC*, Voelkel M, Schneider F, Rossi A, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J (IF: 5.5) * shared first authorship; DOI: 10.1096/fj.201700078R

Koeberle A, Pergola, C., Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O (2015) Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J, 29, 2439-2449 (IF: 5.5); DOI: 10.1096/fj.14-268474

Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O (2013) Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. PNAS, 110 (7), 2546-2551 (IF: 10.7); DOI: 10.1073/pnas.1216182110

Fischer S, Wentsch HK, Mayer-Wrangowski SC, Zimmermann M, Bauer SM, Storch K, Niess R, Koeberle SC, Grütter C, Boeckler FM, Rauh D, Laufer SA (2013) Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J Med Chem, 56 (1), 241-253 (IF: 5.5); DOI:  10.1021/jm301539x

Koeberle SC, Fischer S, Schollmeyer D, Schattel V, Grütter C, Rauh D, Laufer SA (2012) Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem, 55 (12), 5868-5877 (IF: 5.4); DOI: 10.1021/jm300327h

Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA (2011) Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol, 8, 141-3 (IF:16.1); DOI: 10.1038/nchembio.761

Fischer S, Koeberle SC, Laufer SA (2011) p38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011). Expert Opin Ther Pat, 21, 1843-66 (IF:2.1) DOI: 10.1517/13543776.2011.636737

Karcher SC and Laufer, SA (2009) Successful structure-based design of recent p38 MAP kinase inhibitors. Curr Top Med Chem, 9, 655-676 (IF 4.3); DOI: 10.2174/156802609789007363

Karcher SC and Laufer SA (2009) Aza-analogue dibenzepinone scaffolds as p38 MAP kinase inhibitors: Design, synthesis and biological data of inhibitors with improved physico­chemical properties. J Med Chem, 52, 1778-1782 (IF 5.2); DOI: 10.1021/jm801291f

Laufer SA, Ahrens GM, Karcher SC, Hering JS, Niess R. (2006) Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP kinase inhibitors. J Med Chem, 49 (26), 7912-7915 (IF 5.1); DOI: 10.1021/jm061072p

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