Solveigh KoeberleSolveigh KOEBERLE, Dr.
Senior Lecturer

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.032 
6020 Innsbruck / Austria

Phone: +43 512 507 - 58404 | Fax: +43 512 507 - 58499
Email: solveigh.koeberle@uibk.ac.at

 

Research
Publications
Teaching
 Biography
Research interests

Ferroptosis-modulating natural products and their mode of action: Targeting redox-signaling

Ferroptosis is a form of regulated cell death discovered in 2012 that has great potential for novel approaches in the therapy of degenerative diseases as well as (drug-resistant) cancer. The number of proteins involved in ferroptosis is continuously growing as are small molecules that interfere with ferroptotic pathways. Challenges in targeting ferroptosis arise from interference with redox-dependent signaling cascades whose regulatory mechanisms - unlike kinase signaling cascades - are less investigated and not completely understood. Development of drug candidates targeting ferroptosis is still in its infancy and many questions remain unanswered:

  • How to design target-selective ferroptosis inducers? Are multi-target compounds of advantage?
  • Which ferroptotic pathways are predestined targets against therapy-resistant cancer?
  • How does ferroptosis achieve selective lethality of cancer cells?
  • What underlies the synergism between ferroptosis inducers and conventional chemotherapeutics?

Exploiting the enormous structural diversity of natural products might help to answer these questions, identify novel targets and unravel molecular mechanisms.

Subprojects:

  • Bioactivity-guided isolation of ferroptosis-modulating natural compounds.
    • Ferroptosis-inducing compounds as anti-cancer therapy.
    • Ferroptosis-inhibiting compounds for the treatment of degenerative diseases and organ injuries.

  • Identification of molecular targets and define (redox-dependent) signaling pathways.
  • Dissect structural requirements.

Collaborators:

Michael Popp Institute (MPI) Innsbruck

Ferroptosis

Awards, fellowships and fundings
01/2019 - 04/2021 ProChance Grant 2018 (Friedrich-Schiller University of Jena, Germany)
12/2016 - 05/2017 Fellowship of the Leibniz Institute on Aging (Jena, Germany)
09/2014 - 09/2015 Fellowship of the Leibniz Institute on Aging (Jena, Germany)
05/2009 - 05/2011 Fellowship of the „Deutsche Pharmazeutische Gesellschaft“ (DPhG) / Pharmaceutical Society of Japan (PSJ) and of the Takeda Science Foundation for a 2-year research period at The University of Tokyo
06/2005 Participation at the “55th meeting of Nobel laureates in Medicine, Chemistry, and Physics in Lindau” (Germany)

 

 

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