hERGscreen News & Highlights 

 


Meetings, Conferences & Workshops


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 Meetings, Conferences & Workshops



Annual meeting 2013 & 2nd workshop

5. Sept. 2013 in Münster/Germany

Annual meeting called and organized by the coordinator Prof. J.M. Rollinger and Mag. C.E. Mair

Workshop organized by Prof. A.L. Skaltsounis and Dr. M. Halabalaki

'Bioactivity prospection from natural sources'

 Agenda

hERGscreen_meeting_Munster2013

hERGscreen_meeting_Munster2013detail



Kick-off meeting & 1st workshop in Innsbruck/Austria

4.-5. November 2012

University of Innsbruck, CCB, Innrain 80-82

Meeting called and organized by the coordinator Prof. Dr.  J.M. Rollinger and Prof. Dr. A. Marston

'Risk assessment of Phytopharmaceuticals'

Agenda

hERGgroup_2012


 

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Dissemination



Public information

hERGscreen - How safe are botanicals? Judith. M. Rollinger. In Newsletter of the Society for Medicinal Plant and Natural Product Research, July 2013, No.1, p.6

Wie sicher sind Naturstoffe? In Mitteilungsblatt der Universität Innsbruck Wissensbilanz Studienjahr 2011/2012 Ausgegeben am 30. April 2012, S 82
http://www.uibk.ac.at/service/c101/mitteilungsblatt/2011-2012/23/mitteil.pdf


Publications in peer reviewed international journals

  • hERG pharmacophore models as cardiac toxicity prediction tools.Kratz JM, Schuster D, Edtbauer M, Saxena P, Mair CE, Kirchebner J, Matuszczak B, Baburin I, Hering S, Rollinger JM (2014); in revision

  • Natural products as potential hERG channel inhibitors – Outcomes from a screening of widely used herbal medicines and edible plants. Schramm A, Jähne EA, Hering S, Hamburger M (2014); in submission

  • Natural products as potential hERG channel inhibitors – Outcomes from a screening of plant derived alkaloids. Schramm A, Saxena P, Chlebek J, Cahlikova L, Baburin I, Hering S, Hamburger M (2014); in revision

 

Contributions at international conferences

Finding hERG-Blockers among Natural Products: Virtual Screening Workflow and Experimental Validation of Hits. Daniela Schuster, Michael Edtbauer, Jadel M. Kratz, Christina E. Mair, Steffen Hering, Judith M. Rollinger (2013): Oral Presentation at the Congress Trends in natural product research: a young scientist meeting of PSE and ÖPhG, Obergurgl/AT, July 24, 2013

Pharmacophore-based identification of novel hERG channel blockers of natural origin – Development of a virtual screening workflow and experimental validation. Jadel M. Kratz, Michael Edtbauer, Christina E. Mair, Steffen Hering, Daniela Schuster, Judith M. Rollinger (2013): Oral presentation at the 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Münster/G, Sept. 3, 2013

Pharmacophore-based virtual screening as a prioritization tool to assess mechanism-based cardiotoxic effects of small organic molecules. Daniela Schuster, Michael Edtbauer, Jadel M. Kratz, Christina E. Mair, Steffen Hering, Judith M. Rollinger (2013): Oral Presentation at the Eurotox 2013, Interlaken/CH, Sept. 3, 2013

Finding hERG-Blockers among Natural Products: Virtual Screening Workflow and Experimental Validation of Hits. Daniela Schuster, Michael Edtbauer, Jadel M. Kratz, Christina E. Mair, Steffen Hering, Judith M. Rollinger (2013): Poster Presentation at the 5th ÖGMBT Life Science Meeting, Innsbruck/AT, Sept. 26, 2013

hERG pharmacophore models as cardiac toxicity prediction tools. Jadel Müller-Kratz,Daniela Schuster, Michael Edtbauer, Priyanka Saxena, Christina E. Mair, Julia Kirchebner, Barbara Matuszczak, Igor Baburin, Steffen Hering, Judith M. Rollinger (2014): Oral presentation at the  II Simposio Internacional “Nuevos fármacos de origen natural y sintético” (Second international symposium on new drugs of natural and synthetic origin); Universidad de Antioquia, Medellin/Colombia, Mar. 21, 2014


Guest lectures

Pre-clinical cardiac safety testing of drugs and phyto-pharmaceuticals. Steffen Hering (2012): Lecture at the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, Nov. 5, 2012

Virtual screening of hERG blockers - Construction and theoretical validation of ligand-based pharmacophores Jadel Müller-Kratz (2013): Lecture at the Department of Pharmacology and Toxicology, University of Vienna, Vienna/AT, Feb. 20, 2013

Development and validation of a virtual screening workflow for new hERG channel blockers identification. Jadel Müller-Kratz (2013): Lecture at the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, March 22, 2013

Overview and current status of the hERGscreen project. Jadel Müller-Kratz (2013): Seminar at the Department of Pharmaceutical Sciences, Laboratory of Pharmacognosy, Laboratory of Pharmaceutical Chemistry, and Laboratory of Applied Virology, Universidade Federal de Santa Catarina, Florianopolis/BR, May 7, 2013

Chemische Untersuchungen mit Mate, Passiflora und der Pflanzendroge Taguya. Eloir P. Schenkel (2013): Lecture at the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, Aug. 28, 2013

Chemical and neuropharmacological evaluation of the South American Passiflora species. Andressa Gazola: Lecture at the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, Sep. 23, 2013

Analysis and structure elucidation of proanthocyanidins.  Jan van der Westhuizen: Lecture at

  • the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, Oct. 29, 2013;
  • the Department of Pharmaceutical Biology, University of Basel/ CH, Nov. 5, 2013;
  • the Faculty of Pharmacy, Department of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens/EL, Nov. 12, 2014

Library-based discovery of natural product leads.Matthias Hamburger: Lecture at the Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck/AT, Nov. 11, 2013

Side effect predictions using pharmacophore models – General concept and case study on hERG blockers. Daniela Schuster: Lecture at the Institute of Pharmacy, Freie Universität Berlin, Berlin/DE, Oct. 29, 2013

In silico driven pharmacognosy to access Nature’s treasures. Judith Rollinger: Lecture at the Department of Pharmaceutical Biology, University of Basel/ CH, Mar. 5, 2014

Bioactive compounds from Nature’s laboratory. Judith Rollinger:
Lecture at the Department of Pharmaceutics, College of Pharmacy, University of Florida/US, Feb. 27, 2014

Profiling for desirable and unwanted pharmacological activities in plant extracts.Matthias Hamburger: Seminar at the Faculty of Natural Sciences, University of the Free State, Blomfontein/ZA, Jan. 30, 2014

 

Workshops

Kick-off Meeting and 1st hERGscreen workshop, Risk assessment of Phytopharmaceuticals organized by J.M. Rollinger (UIBK) & A. Marston (UFS), Innsbruck, Austria, Nov. 4/5, 2012

2nd hERGscreen workshop, Bioactivity prospection from natural sources organized by A.L. Skaltsounis and M. Halabalaki (NKUA), Munster, Germany, Sept. 5, 2013


PhD- and diploma theses

  • Modulation of ion channels by natural products- identification of hERG channel inhibitors and GABAA receptor ligands from plant extracts. PhD thesis of Anja Schramm, under supervision of Prof. M. Hamburger, University of Basel/Switzerland, 2014
  • Search for hERG channel interacting compounds from natural sources and isolation of active compounds from Nelumbo nucifera Gaertn. Diploma thesis of Stefanie Lehmann under supervision of Prof. J.M. Rollinger, University of Innsbruck/Austria, 2013