Univ.Prof. Dr. Ronald MICURA

Univ.Prof. Dr. Ronald MICURA

Department of Organic Chemistry
University of Innsbruck
Innrain 80-82
6020 Innsbruck
Austria/Europe

phone: +43 512 507 57710
fax: +43 512 507 57799

https://www.uibk.ac.at/organic/micura/

ronald.micura@uibk.ac.at


Publications

2024

  • L. Flemmich, R. Bereiter, R. Micura*; 'Chemical synthesis of modified RNA'; Angew. Chem. Int. Ed. 2024, 63, e202403063.
  • K. Bartosik, R. Micura*; 'Access to capped RNA by chemical ligation'; RSC. Chem. Biol. 2024, accepted.
  • S. Heel, F. Juen, K. Bartosik, R. Micura, C. Kreutz, K. Breuker*; 'Resolving the intricate binding of neomycin B to multiple binding motifs of a neomycin-sensing riboswitch aptamer by native top-down mass spectrometry and NMR spectroscopy'; Nucleic Acids Res. 2024, 52, 4691-4701.
  • M. Kompatscher, K. Bartosik, K. Erharter, R. Plangger, F. S. Juen, C. Kreutz, R. Micura, E. Westhof, M. D. Erlacher*. Contribution of tRNA sequence and modifications to the decoding preferences of E. coli and M. mycoides tRNAGlyUCC for synonymous glycine codons. Nucleic Acids Res. 2024, 52, 1374-1386.

2023

  • Y. S. Polikanov*, M. Etheve-Quelquejeu, R. Micura*; 'Synthesis of peptidyl-tRNA mimics for structural biology applications'; Acc. Chem. Res. 2023, 56, 2713-2725.
  • C. Eichler #, M. Himmelstoß #, R. Plangger, L. I.  Weber, M. Hartl, C. Kreutz*, R. Micura*; 'Advances in RNA labeling with trifluoromethyl groups'; Chem. Eur. J. 2023, 29, e202302220. # these authors contributed equally
  • J. Thaler #, E. Syroegin #, K. Breuker, Y. Polikanov*, R. Micura*; 'Practical synthesis of N-formylmethionylated peptidyl-tRNA mimics'; ACS Chem. Biol. 2023, 18, 2233–2239. # these authors contributed equally
  • S. Heel, K. Bartosik, F. Juen, C. Kreutz, R. Micura, K. Breuker*; 'Native top-down mass spectrometry uncovers two distinct binding motifs of a functional neomycin-sensing riboswitch aptamer'; J. Am. Chem. Soc. 2023, 145, 15284–15294.
  • X. Xu #, M. Egger #, C. Li #, H. Chen, R. Micura*, A. Ren*; 'Structure-based investigations of the NAD+-II riboswitch'; Nucleic Acids Res. 2023, 51, 54–67. # these authors contributed equally 

2022

  • M. Egger, R. Bereiter, S. Mair, R. Micura*; 'Scaling catalytic contributions of small self-cleaving ribozymes'; Angew. Chem. Int. Ed. 2022, 61, e202207590.
  • E. A. Syroegin #, L. Flemmich #, D. Klepacki, N. Vazquez-Laslop, R. Micura*, Y. Polikanov*; 'Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol'; Nat. Struct. Mol. Biol. 2022, 29, 152–161. # these authors contributed equally; see News&Views by C. Crowe-McAuliffe & D. N. Wilson, Putting the antibiotics chloramphenicol and linezolid into context, Nat. Struct. Mol. Biol. 2022, 29, 79–91.
  • S. Moreno, M. Brunner, I. Delazer, D. Rieder, A. Lusser,* R. Micura*; 'Synthesis of 4-thiouridines with prodrug functionalization for RNA metabolic labeling'; RSC Chem. Biol. 2022, 3, 447–455.
  • S. Moreno, J. M. Ramos Pittol, M. Hartl, R. Micura*; 'Robust synthesis of 2'-azido modified RNA from 2'-amino precursors by diazotransfer reaction'; Org. Biomol. Chem. 2022, 20, 7845–7850.
  • S. Moreno, M. Fickl, I. Bauer, M. B., A. Rázková, D. Rieder, I. Delazer, R. Micura,* A. Lusser*; 6-Thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells, J. Med. Chem. 2022, 65, 15165–15173.
  • S. Mair, K. Erharter, E. Renard, K. Brillet, M. Brunner, A. Lusser, C. Kreutz*, E. Ennifar,* R. Micura*; 'Towards a comprehensive understanding of RNA deamination – Synthesis and properties of xanthosine-modified RNA'; Nucleic Acids Res. 2022, 50, 6038–6051.
  • R. Bereiter, E. Renard, K. Breuker, C. Kreutz, E. Ennifar, R. Micura*; '1-Deazaguanosine modified RNA – The missing piece for functional RNA atomic mutagenesis'; J. Am. Chem. Soc. 2022, 144, 10344–10352.
  • R. Bereiter, M. Oberlechner, R. Micura*; 'A new route for the synthesis of 1-deazaguanine and 1-deazahypoxanthine'; Beilstein. J. Org. Chem. 2022, 18, 1617–1624.
  • S. Moreno, L. Flemmich, R. Micura*; 'Synthesis of N4-acetylated 3-methylcytidine phosphoramidites for RNA solid-phase synthesis'; Monatshefte für Chemie - Chemical Monthly, 2022, 153, 285–291.
  • L. Bessler, N. Kaur, L.-M- Vogt, L. Flemmich, C. Siebenaller, M.-L. Winz, F. Tuorto, R. Micura, A. Ehrenhofer-Murray,* M. Helm*; 'Functional integration of a semi-synthetic azido-queuosine derivative into translation and a tRNA modification circuit', Nucleic Acids Res. 2022, 50, 10785–10800.
  • F. Erhard*, E. Saliba, A. Lusser, C. Toussaint, T. Hennig, B. Prusty, D. Kirschenbaum, K. Abadie, E. Miska, C. Friedel, I. Amit, R. Micura, L. Dölken*; 'Time-resolved single-cell RNA-seq using metabolic RNA labeling', Nat. Rev. Methods Primers 2022, 2, 77.
  • M. Mitter*, Z. Takacs, T. Köcher, R. Micura, C. Langer, D. Gerlich*; 'Sister-chromatid-sensitive Hi-C to map the conformation of replicated genomes'; Nat. Protoc. 2022, 17, 1486–1517

2021

  • L. Flemmich, S. Heel, S. Moreno, K. Breuker, R. Micura*; 'A natural riboswitch scaffold with self-methylation activity'; Nat. Commun. 2021, 12, 3877.
  • L. Flemmich, S. Moreno, R. Micura*; 'Synthesis of O6-alkylated preQ1 derivatives'; Beilstein J. Org. Chem. 2021, 17, 2295–2301.
  • R. Bereiter #, M. Himmelstoß #, E. Renard, E. Mairhofer, M. Egger, K. Breuker, C. Kreutz,  E. Ennifar, R. Micura*; 'Impact of 3-deazapurine nucleobases on RNA properties'; Nucleic Acids Res. 2021, 49, 4281–4293. # these authors contributed equally
  • X. Xu #, M. Egger #, H. Chen #, K. Bartosik, R. Micura*, A. Ren*; 'Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition'; Nucleic Acids Res. 2021, 49, 7139 - 7153. # these authors contributed equally
  • O. A. Krasheninina, J. Thaler, M. E. Erlacher, R. Micura*; 'Amine-to-azide conversion on native RNA via metal-free diazo transfer opens new avenues for RNA manipulations'; Angew. Chem. Int. Ed. 2021, 60, 6970-6974.
  • C. Falschlunger, J. Leiter, R. Micura*; 'Elucidation of Ribozyme Mechanisms at the Example of the Pistol Ribozyme', in Ribozymes - Principles, Methods, Applications, Eds.: S. Müller, B. Masquida, W. Winkler, Wiley-VCH, Weinheim, 2021.

2020

  • R. Micura,* C. Höbartner*; 'Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes'; Chem. Soc. Rev. 2020, 7331-7535.
  • M. Himmelstoß, K. Erharter, E. Renard, E. Ennifar,* C. Kreutz,* R. Micura*; '2′-O-Trifluoromethylated RNA – A powerful modification for RNA chemistry and NMR spectroscopy'; Chem. Sci. 2020, 11, 11322-11330.
  • C. Gasser #, I. Delazer #, E. Neuner +, K. Pascher +, K. Brillet, S. Klotz, L. Trixl, M. Himmelstoß, E. Ennifar, D. Rieder,* A. Lusser,* R. Micura*; 'Thioguanosine conversion enables mRNA life-time evaluation by RNA sequencing via double metabolic labeling (TUC-seq DUAL)'; Angew. Chem. Int. Ed. 2020, 59, 6881-6886. #,+ these authors contributed equally
  • M. Teplova #, C. Falschlunger #, O. Krasheninina #, M. Egger, A. Ren, D. J. Patel,* R. Micura*; 'On crucial roles of two hydrated Mg2+ ions in reaction catalysis of the pistol ribozyme'; Angew. Chem. Int. Ed. 2020, 59, 2837-2843. # these authors contributed equally
  • H. Chen #, M. Egger #, X. Xu #, L. Flemmich, O. Krasheninina, A. Sun, R. Micura,* A. Ren*; 'Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding'; Nucleic Acids Res. 2020, 48, 12394–12406. # these authors contributed equally
  • M. Mitter,* C. Gasser, Z. Takacs, C. H. C. Langer, W. Tang, G. Jessberger, C. T. Beales, E. Neuner, S. L. Ameres, J.-M. Peters, A. Goloborodko, R. Micura, D. W. Gerlich*; 'Conformation of sister-chromatids in the replicated human genome'; Nature 2020, 586, 139-144.
  • J. Leiter, D. Reichert, A. Rentmeister, R. Micura*; 'Practical Synthesis of Cap-4 RNA'; ChemBioChem 2020, 21, 265-271.
  • A. Lusser*, C. Gasser, L. Trixl, P. Piatti, D. Rieder, J. Bashin, I. Delazer, C. Riml, T. Amort, R. Micura*; 'Thiouridine-to-Cytidine conversion sequencing (TUC-seq) to measure mRNA transcription and degradation rates'; Meth. Mol. Biol. 2020, 2062, 191-211.
  • S. Werner, L. Schmidt, V. Marchand, T. Kemmer, C. Falschlunger, M. V. Sednev, G. Bec, E. Ennifar, C. Höbartner, R. Micura, Y. Motorin, A. Hildebrandt, M. Helm*; Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes'; Nucleic Acids Res. 2020, 48, 3734-3746.

2019

  • A. Sun #, C. Gasser #, F. Li #, H. Chen, S. Mair, O. Krasheninina, R. Micura,* A. Ren*; 'SAM-VI riboswitch structure and signature for ligand discrimination'; Nat. Commun. 2019, 10, 5728. # these authors contributed equally
  • E. Mairhofer, L. Flemmich, C. Kreutz, R. Micura*; 'Access to 3-Deazaguanosine Building Blocks for RNA Solid-Phase Synthesis Involving Hartwig-Buchwald C-N Cross-Coupling'; Org. Lett., 2019, 21, 3900-3903.
  • L. Zheng #, C. Falschlunger #, K. Huang, E. Mairhofer, S. Yuan, J. Wang, Dinshaw J. Patel*, R. Micura*, A. Ren*; 'Hatchet ribozyme structure and implications for cleavage mechanism'; Proc. Nat. Acad. Sci. 2019, 116, 10783-10791. # these authors contributed equally
  • S.V. Melnikov, N.F. Khabibullina, E. Mairhofer, O. Vargas-Rodriguez, N.M. Reynolds, R. Micura,* D. Söll*, Y.S. Polikanov*; 'Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site'; Nucl. Acids Res. 2019, 47, 2089-2100.
  • E. Fuchs, C. Falschlunger, R. Micura, K. Breuker*; 'The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry'; Nucl. Acids Res. 2019, 47, 7223-7234.
  • C. Falschlunger, R. Micura*; 'Efficient access to N‐trifluoroacetylated 2′‐amino‐2′‐deoxyadenosine phosphoramidite for RNA solid‐phase synthesis'; Monatshefte für Chemie - Chemical Monthly, 2019, 150, 795-800.
  • E. Neuner, R. Micura*; 'Practical synthesis N-(di-n-butylamino)methylene protected 2-aminopurine riboside phosphoramidite for RNA solid-phase synthesis'; Monatshefte für Chemie - Chemical Monthly, 2019, 1941–1946.
  • C. Dégut, V. Schwarz, L. Ponchon, P. Barraud, R. Micura, C. Tisné*; 'Design of cross-linked RNA/protein complexes for structural studies'; Biochimie, 2019, 164, 95-98.
  • S. Mukherjee, L. Błaszczyk, W. Rypniewski, C. Falschlunger, R. Micura, A. Murata, C. Dohno, K. Nakatani*, A. Kiliszek*; 'Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats'; Nucl. Acids Res. 2019, 47, 10906-10913.

2018

  • E. Neuner #, M. Frener #, A. Lusser*, R. Micura*; 'Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ1 riboswitches in E.coli'; RNA Biol. 2018, 15, 1376-1383# these authors contributed equally
  • C. Gasser, J. Gebetsberger*, M. Gebetsberger, R. Micura*; 'SHAPE probing pictures Mg2+ dependent folding of small self-cleaving ribozymes'; Nucl. Acids Res. 2018, 46, 6983-6995.
  • T.P. Hoernes, K. Faserl, M.A. Juen, J. Kremser, C. Gasser, E. Fuchs, Xi. Shi, A. Siewert, H. Lindner, C. Kreutz, R. Micura, S. Joseph, C. Höbartner, E. Westhof, A. Hüttenhofer, M.D. Erlacher*; 'Translation of non-standard nucleotides reveals minimal requirements for codon-anticodon interactions', Nat. Commun. 2018, 9, 4865.

2017

2016

  • M. Frener, R. Micura*; 'Conformational rearrangements of individual nucleotides during RNA-ligand binding are rate-differentiated'; J. Am. Chem. Soc. 2016, 138, 3627-3630.
  • E. Mairhofer #, E. Fuchs #, R. Micura*; 'Facile synthesis of 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis'; Beilstein J. Org. Chem. 2016, 12, 2556-2562. # these authors contributed equally
  • A. Ren #, N. Vusurovic #, J. Gebetsberger, P. Gao, M. Juen, C. Kreutz, R. Micura,* D.J. Patel*; 'Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage'; Nat. Chem. Biol. 2016, 12, 702-708. # these authors contributed equally
  • S. Melnikov, J. Mailliot, L. Rigger, S. Neuner, B.-S. Shin, G. Yusupova, T. E. Dever,* R. Micura*, M. Yusupov*; 'Molecular insights into protein synthesis with proline residues'; EMBO Reports 2016, 17, 1776-1784.
  • S. Sothiselvam, S. Neuner, L. Rigger, D. Klepacki, R. Micura, N. Vázquez-Laslop,* A. S. Mankin*; 'The ribosome corrupted by macrolide antibiotics discriminates against specific substrates based on their charge and size'; Cell Reports 2016, 16, 1789-1799.
  • C. Riml, R. Micura*; 'Synthesis of 5-hydroxymethylcytidine and 5-hydroxymethyluridine-modified RNA'; Synthesis 2016, 48, 1108-1116.
  • S. Melnikov, J. Mailliot, B.-S. Shin, L. Rigger, G. Yusupova, R. Micura*, T. E. Dever,* M. Yusupov*; 'Crystal structure of hypusine-containing translation fachtor eIF5A bound to a rotated eukaryotic ribosome'; J. Mol. Biol. 2016, 428, 3570-3576.
  • S. Flür, R. Micura*; 'Chemical synthesis of RNA with site-specific methylphosphonate modifications'; Methods 2016, 107, 79-88.

2015

  • M. Kosutic #, S. Neuner #, A. Ren, S. Flür, C. Wunderlich, E. Mairhofer, N. Vusurovic, J. Seikowski, K. Breuker, C. Höbartner, D.J. Patel,* C. Kreutz,* R. Micura*; 'A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class'; Angew. Chem. Int. Ed. 2015, 54, 15128-15233. # these authors contributed equally
  • S. Neuner #, T. Santner #, C. Kreutz, R. Micura*; 'The "speedy" synthesis of atom-specific 15N imino/amido-labeled RNA'; Chem. Eur. J. 2015, 21, 11634-11643. # these authors contributed equally.
  • L. Jud #, M. Kosutic #, V. Schwarz, M. Hartl, C. Kreutz, K. Bister, R. Micura*; 'Expanding the scope of 2'-SCF3 modified RNA'; Chem. Eur. J. 2015, 21, 10400-10407. # these authors contributed equally.
  • M. Koch #, S. Flür #, C. Kreutz, R. Micura*, N. Polacek*; 'The role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis'; Proc. Nat. Acad. Sci. 2015, 112, E6256–E6259. # these authors contributed equally.
  • C. Riml, H. Glasner, M. T. Rodgers, R. Micura, K. Breuker*; 'On the mechanism of RNA phosphodiester backbone cleavage in the absence of solvent'; Nucl. Acids Res. 2015, 43, 5171-5181.
  • T. Moschen, C. H. Wunderlich, R. Spitzer, J. Levic, R. Micura, M. Tollinger*, C. Kreutz*; 'Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1–RNA Binding'; Angew. Chem. Int. Ed. 2015, 570-573.
  • A.-S. Geiermann, R. Micura; 'Native chemical Ligation of hydrolysis-resistant 3'-NH-cystein-modified RNA'; Curr. Protoc. Nucl. Acid Chem. 2015, Wiley, 62:4.64.1-4.64.36.

2014

2013

2012

  • K. Fauster, C. Kreutz, R. Micura*; '2'-SCF3 uridine - A novel powerful label for probing RNA structure and function by 19F-NMR spectroscopy'; Angew. Chem. Int. Ed. 2012, 51, 13080-13084; Angew. Chem. 2012, 124,13257-13261

  • V. Siegmund, T. Santner, R. Micura, A. Marx*; 'Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2'-modified nucleotides'; Chem. Comm. 2012, 48, 9870-9872

  • T. Santner #, U. Rieder #, C. Kreutz*, R. Micura*; 'Pseudoknot preorganization of the preQ1 class I riboswitch'; J. Am. Chem. Soc. 2012, 134, 11928-11931. # these authors contributed equally

  • A.-S. Geiermann, R. Micura*; 'Selective desulfurization significantly expands sequence variety of 3’-peptidyl-tRNA mimics obtained by native chemical ligation'; Chembiochem 2012, 12,1742-1745

  • T. Santner, V. Siegmund, A. Marx, R. Micura*; The synthesis of 2'-methylseleno adenosine and guanosine 5'-triphosphates; Bioorg. Med. Chem. 2012, 20, 2416-2418. (Front cover)

  • K. Fauster, M. Hartl, T. Santner, M. Aigner, C. Kreutz, K. Bister*, E. Ennifar*, R. Micura*; 2-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling; ACS Chem. Biol. 2012, 7, 581-589. (Front cover)

  • R. Micura; book review on 'Metal Ions in Life Sciences, Vol. 9., Structural and Catalytic Roles of Metal Ions in RNA', A. Sigel, H. Sigel, R.K.O. Sigel (Eds.) RSC Publishing (2011); Coord. Chem. Rev. 2012, 256, 370

  • D. Graber, K. Trappl, J. Steger, A.-S. Geiermann, L. Rigger, H. Moroder, N. Polacek, R. Micura*; 'Deoxyribozyme-based, semisynthetic access to stable peptidyl-tRNAs exemplified by tRNA(Val) carrying a macrolide antibiotic resistance peptide'; in Ribozymes (Ed. J. S. Hartig), Meth. Mol. Biol. 2012, 848, 201-213.

2011

  • A.-S. Geiermann, N. Polacek, R. Micura*; 'Native chemical ligation of hydrolysis-resistant 3’-peptidyl-tRNA mimics'; J. Am. Chem. Soc. 2011, 133, 19068-19071.

  • M. Soulière, A. Haller, R. Rieder, R. Micura*; 'A powerful approach for the selection of 2-aminopurine substitution sites to investigate RNA folding'; J. Am. Chem. Soc. 2011, 133, 16161-16167

  • V. Siegmund, T. Santner, R. Micura*, A. Marx*; 'Enzymatic synthesis of 2'-methylseleno-modified RNA'; Chem. Sci. 2011, 2, 2224-2231

  • J. Steger, R. Micura*; 'Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs'; Bioorg. Med. Chem. 2011, 19, 5167-5174

  • A. Haller #, M. F. Soulière #, R. Micura*; 'The dynamic nature of RNA as key to understanding riboswitch mechanisms'; Acc. Chem. Res. 2011, 44, 1339-1348. # these authors contributed equally

  • A. Haller, U. Rieder, M. Aigner, S. C. Blanchard*, R. Micura*; 'Conformational capture of the SAM-II riboswitch'; Nat. Chem. Biol. 2011, 7, 393-400.
    News&Views by Ming C. Hammond; 'RNA folding: A tale of two riboswitches'; Nat. Chem. Biol. 2011, 7, 342-343

  • H. Ramu, N. Vázquez-Laslop, D. Klepacki, Q. Dai, J. Piccirilli, R. Micura, A. S. Mankin*; 'Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-Site of the Peptidyl Transferase Center'; Mol. Cell. 2011, 41, 321-330.
    Preview by D. N. Wilson*; 'Peptides in the Ribosomal Tunnel Talk Back'; Mol. Cell 2011, 41, 247-248

  • M. Aigner, M. Hartl, K. Fauster, J. Steger, K. Bister, R. Micura*; 'Chemical Synthesis of Site-Specifically 2'-Azido-Modified RNA and Potential Applications for Bioconjugation and RNA Interference'; Chembiochem 2011, 11, 47-51

2010

2009

  • A.-S. Geiermann, R. Micura*; 'Chasing after antibiotic leads'; Chem. Biol. 2009, 16, 1024-1025 (Preview).
  • B. Puffer, C. Kreutz, U. Rieder, M.-O. Ebert, R. Konrat, R Micura*; '5-Fluoro pyrimidines: Labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy';  Nucl. Acids Res. 2009, 37, 7728-7740.
  • K. De Mulder, D. Pfister, G. Kuales, B. Egger, W. Salvenmoser, M. Willems, J. Steger, K. Fauster, R. Micura, G. Borgonie, P. Ladurner*; 'Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms'; Dev. Biol. 2009, 334, 198-212.
  • U. Rieder, K. Lang, C. Kreutz, N. Polacek, R. Micura*; 'Evidence for Pseudoknot Formation of Class I preQ1 Riboswitch Aptamers'; Chembiochem 2009, 10, 1141-1144.
  • H. Moroder #, J. Steger #, D. Graber, K. Fauster, K. Trappl, V. Marquez, N. Polacek, D. N. Wilson, R. Micura*; 'Nonhydrolyzable RNA–Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3'-Peptidyl tRNA Termini'; Angew. Chem. Int. Ed. Engl. 2009, 48, 4056-4060; Angew. Chem. 2009, 121, 4116-4120. # these authors contributed equally
  • V. Olieric #, U. Rieder #, K. Lang, A. Serganov, C. Schulze-Briese, R. Micura, P. Dumas, E. Ennifar*; 'A fast strategy for selenium derivatization directed to phasing of X-ray RNA structures'; RNA 2009, 15, 707-715.# these authors contributed equally
  • R. Rieder, C. Höbartner, R. Micura*; 'Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications', in Riboswitches (Ed. A. Serganov), Meth. Mol. Biol. 2009, 540, 15-24.

2008

2007

  • F. Li, P. Pallan, M. Maier, K. Rajeev, S. Mathieu, C. Kreutz, Y. Fan, J. Sanghvi, R. Micura, E. Rozners, M. Manoharan, M. Egli*; 'Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme'; Nucl. Acids Res. 2007, 35, 6424-6438.
  • K. Lang, R. Rieder, R. Micura*; 'Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach'; Nucl. Acids Res. 2007, 35, 5370-5378.
  • M. Amort, B. Wotzel, K. Bakowska-Zywicka, M. D. Erlacher, R. Micura, and N. Polacek*; 'An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination'; Nucl. Acids Res. 2007, 35, 5130-5140.
  • R. Rieder, K. Lang, D. Graber, R. Micura*; 'Ligand-Induced Folding of the Adenosine Deaminase A-Riboswitch and Implications on Riboswitch Translational Control'; Chembiochem 2007, 8, 896 - 902.
  • R. Micura; 'RNA – Struktur und Funktion'; Trendbericht, Nachrichten aus der Chemie 2007, 55, 279-284.

2006

2005

  • C. Kreutz, H. Kählig, R. Konrat*, R. Micura*, 'Ribose 2'-F labeling: A simple tool for the characterization of RNA secondary structure equilibria by 19F-NMR spectroscopy', J. Am. Chem. Soc. 2005, 127, 11558-11559.
  • C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, R. Micura*, 'Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-Se-methyl labels for use in X-ray crystallography', J. Am. Chem. Soc. 2005, 127, 12035-12045.
  • M. D. Erlacher, K. Lang, N. Shankaran, B. Wotzel, A. Hüttenhofer, R. Micura, A. S. Mankin, N. Polacek*; 'Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-O-hydroxyl group of A2451'; Nucl. Acids Res. 2005, 33, 1618-1627.
  • A. Serganov, S. Keiper, L. Malinina, V. Tereshko, E. Skripkin, C. Hobartner, A. Polonskaia, A. T. Phan, R. Wombacher, R. Micura, Z. Dauter, A. Jaschke*, D. J. Patel*; 'Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation'; Nat. Struct. Mol. Biol. 2005, 12, 218 - 224.

2004

2003

  • S. Pitsch, S. Wendeborn, R. Krishnamurthy*, A. Holzner, M. Minton, M. Bolli, C. Miculka, N. Windhab, R. Micura, M. Stanek, B. Jaun, A. Eschenmoser*; 'The ß-D-Ribopyranosyl-(4'-2')-Oligonucleotide System ('Pyranosyl-RNA'): Synthesis and Resume of Base-Pairing Properties'; Helv. Chim. Acta 2003, 12, 4270-4363.
  • R. Micura*, and C. Hoebartner; 'On RNA secondary structure rearrangements and equilibria of small RNAs'; ChemBioChem 2003, 4, 984-990.
  • C. Hoebartner, C. Kreutz, E. Flecker, E. Ottenschlaeger, W. Pils, K. Grubmayr, R. Micura*; 'The synthesis of 2'-O-[(triisopropylsilyl)oxy]methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis'; Monatshefte für Chemie - Chemical Monthly, 2003, 134, 851-873.
  • C. Hoebartner, R. Micura*; 'Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy'; J. Mol. Biol. 2003, 325, 421-431.

2002

2001

  • R. Micura*, W. Pils, C. Hoebartner, K. Grubmayr, M.-O. Ebert, B. Jaun; 'Methylation of nucleobases in RNA oligonucleotides mediates hairpin-duplex conversion'; Nucleic Acids Res. 2001, 29, 3997-4005.
  • R. Micura*, W. Pils, K. Grubmayr, M.-O. Ebert, B. Jaun; 'Bridged Cyclic Oligoribonucleotides - towards Models for Codon-Anticodon Pairing'; Nucleosides, Nucleotides, Nucleic Acids 2001, 20, 1287-1289.

2000

1999

1997

  • M. Bolli, R. Micura, S. Pitsch and A. Eschenmoser*; 'Pyranosyl-RNA: Further Observations on Replication'; Helv. Chem. Acta 1997, 80, 1901-1951.
  • M. Bolli, R. Micura, and A. Eschenmoser*; 'Pyranosyl-RNA: Chiroselective self-assembly of base sequences by ligative oligomerization of tetranucleotide-2',3'-cyclophosphates (with a commentary concerning the origin of biomolecular homochirality)'; Chem.&Biol. 1997, 4, 309-320.
  • R. Micura, M. Bolli, N. Windhab and A. Eschenmoser*; 'Pyranosyl-RNA Also Forms Hairpin Structures', Angew. Chem. 1997, 109, 899-902; Angew. Chem. Int. Ed. Engl. 1997, 36, 870-873.

1996

  • R. Micura* and K. Grubmayr; 'The Enantiomers of Phycocyanobilin Dimethyl Ester: A Facile Approach via Semipreparative Enantioselective Chromatography of their Ring-D Methyl Imino Esters'; Enantiomer 1996, 1, 109-113.
  • H. Falk*, R. Micura, M. Stanek, and R. Wutka; 'Structural Aspects of Native and Acid or Enzyme Degraded Amylopectins - a 13C NMR Study', Starch/Stärke 1996; 48, 344-346.
  • H. Falk*, Q.-Q. Chen, and R. Micura; 'On the Chemistry of Pyrrole Pigments, XCVII: Synthesis, Stereochemistry, and Solvatochromic Effects of a 1-(Dipyrrinon-9-yl)-3-(dipyrrinon-9-ylidene)-1-propene'; Monatsh. 1996, 127, 77-83.

1995

  • R. Micura and K. Grubmayr*; 'A Phycocyanobilin Seryliminoester as a New Model for the Chromophore-Protein Interaction in Phytochrome'; Angew. Chem. 1995, 107, 1896-1898; Angew. Chem. Int. Ed. Engl. 1995, 34, 1733-1735.
  • Q.-Q. Chen, H. Falk*, and R. Micura; 'On the Chemistry of Pyrrole Pigments, XCII: Syntheses of 1,2-Bis-pyrrolylethanes'; Monatsh. 1995, 126, 473-479.

1994

  • R. Micura and K. Grubmayr*; 'Long-wavelength absorbing derivatives of phycocyanobilin: new structural aspects on phytochrome'; Bioorg. Med. Chem. Lett. 1994, 4, 2517-2522.
Nach oben scrollen