Date Title, Reference PDF 

Total Synthesis of (–)-Ambiguine P Using Sequential Indole Fuctionalizations

R. E. Johnson, H. Ree, M. Hartmann, L. Lang, S. Sawano, R. Sarpong, J. Am. Chem. Soc. 2019, 141, 2233–2237.

p / k p / k

Total synthesis of solanoeclepin A

K. Tanino, M. Takahashi, Y. Tomata, H. Tokura, T. Uehara, T. Narabu, M. Miyashita, Nat. Chem. 2011, 3, 484–488.

p / k p / k

Total Synthesis of Epicolactone

A. G. Kravina, E. M. Carreira, Angew. Chem. Int. Ed. 2018, 57, 13159–13162.

p / k p / k

Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV

M. M. Logan, T. Toma, R. Thomas-Tran, J. Du Bois, Science 2016, 354, 865–869.

p / k p / k

Total Synthesis of (–)-Isoschizoagamine

Y. Miura, N. Hayashi, S. Yokoshima, T. Fukuyama, J. Am. Chem. Soc. 2012, 134, 11995.

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A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin

W. He, Z. Zhang, D. Ma, Angew. Chem. Int. Ed. 2019, 58, 1–5.

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Total Synthesis of Astellatol

N. Zhao, S.Yin, S. Xie, H. Yan, P. Ren, G Chen, F. Chen, J. Xu, Angew. Chem. Int. Ed. 2018, 57, 3386.

p / k p / k

Total Synthesis of Aplysiasecosterol A

Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li, J. Am. Chem. Soc. 2018, 140, 9211–9218.

p / k p / k

Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids

X. Yu, F. Su, C. Liu, H. Yuan, S. Zhao, Z. Zhou, T. Quan, T. Luo, J. Am. Chem. Soc. 2016, 138, 6261.

p / k p / k

Total Synthesis of (–)-Nahuoic Acid Ci (Bii)

Q. Liu, Y. Deng, A. B. Smith III, J. Am. Chem. Soc. 2017, 139, 13668–13671.

p / k p / k

Total Syntheses of Highly Oxidized ent-Kaurenoid Pharicin A, Pharicinin B, 7-O-Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach

C. He, J. Hu, Y. Wu, H. Ding, J. Am. Chem. Soc. 2017, 139, 6098–6101.

p / k p / k

Formal Total Synthesis of (+)-Pleuromutilin

E. P. Farney, S. S. Feng, F. Schäfers, S. E. Reisman, J. Am. Chem. Soc. 2018, 140, 1267–1270.

p / k p / k

Total Synthesis of Isodihydrokoumine

J. K. Kerkovius, M. A. Kerr, J. Am. Chem. Soc. 2018, 140, 8415.

p / k p / k

A Benzyne-Insertion Approach to Hetisine-Type Diterpenoid Alkaloids:
Synthesis of Cossonidine (Davisine)

K. G. M. Kou, J. J. Pflueger, T. Kiho, L. C. Morrill, E. L. Fisher, K. Clagg, T. P. Lebold, J. K. Kisunzu, R. Sarpong, J. Am. Chem. Soc. 2018, 140, 8105.

p / k p / k

Intramolecular Photocycloaddtion-Cyclobutane Fragmentation: Total Synthesis of (±)-Silphinene

M.T. Crimmins, S. W. Mascarella, J. Am. Chem. Soc. 1986, 108, 3435–3438.

p / k p / k

Total Synthesis of (–)-Histrionicotoxin and (–)-Histrionicotoxin 235A

G. Stork, K. Zhao, J. Am. Chem. Soc. 1990, 112, 5875.

p / k p / k

Total Synthesis of (±)-Nakafuran-8

T. Uyehara, M. Sugimoto, I. Suzuki, Y. Yamamoto,  J. Chem. Soc. Chem. Commun. 1989, 1841–1842.

p / k p / k

Total Synthesis of (–)-Chromodorolide B

D. J. Tao, Y. Slutskyy, M. Muuronen, A. Le, P. Kohler, L. E. Overman,  J. Am. Chem. Soc. 2018, 140, 3091–3102.

p / k p / k

Bioinspired Total Synthesis of Sespenine

Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li, Angew. Chem. Int. Ed. 2014, 53, 9012–9016.

p / k p / k

Enantioselective Total Synthesis of (+) and (–)-Nigellamine A2

J. Bian, M. van Wingerden, J. M. Ready, J. Am. Chem. Soc. 2006, 128, 7428–7429.

p / k p / k

A Diosphenol-Based Strategy for the Total Synthesis of (–)-Terpestacin

B. M. Trost, G. Dong, J. A. Vance, J. Am. Chem. Soc. 2005, 129, 4541.

p / k p / k

A Concise, Efficient and Scalable Total Synthesis of Thapsigargin and Nortilobide

D. Chen, P. A. Evans, J. Am. Chem. Soc. 2017, 139, 6046–6049.

p / k p / k

Enantioselective Total Synthesis of (–)-Pavidolide B

P.-P. Zhang, Z.-M. Yang, J.-X.Gong, Z. Yang, J. Am. Chem. Soc. 2017, 139, 13989–13992.

p / k p / k

Synthesis of (–)-11-O-Debenzoyltashironin: Neurotropic Sesquiterpenes cause Hyperexcitation

M. Ohtawa, M. J. Krambis, R. Cerne, J. M. Schkeryantz, J.M. Witkin, R. A. Shenvi, J. Am. Chem. Soc. 2017, 139, 9637–9644.

p / k p / k

Synthesis and Structure Revision of Dichrocephones A and B

V. M. Schmiedel, Y. J. Hong, D. Lentz, D. J. Tantillo, M. Christmann, Angew. Chem. Int. Ed. 2018, 57, 2419–2422.

p / k p / k

Synthesis of (±)-Merrilactone A by Desymmetrization Strategy

W. Liu, B. Wang, Chem. Eur. J. 2018. DOI: 10.1002/chem.201804195.

p / k p / k

Total synthesis of natural (–)-echinosporin. Determination of the absolute configuration

A. B. Smith III, G. A. Sulikowski, K. Fujimoto, J. Am. Chem. Soc. 1989, 111, 8039–8041.

p / k p / k

Total Synthesis of (±)-Aspergilline A

M. C. Nakhla, J. L. Wood, J. Am. Chem. Soc. 2017, 139, 18504–18507.

p / k p / k

Asymmetric Total Syntheses of Colchicine, b-Lumicolchicine, and Allocolchicinoid N-Acetylcolchinol-O-methyl Ether (NCME)

B.Chen, X. Liu, Y. J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye, C.-C. Li, Chem. Sci. 2017, 8, 4961–4966.

X. Liu, Y.-J. Hu, B. Chen, L- Min, X.-S. Peng, J. Zhao, S. Li, H.N.C. Wong, C.-C. Li, Org. Lett. 2017,19, 4612–4615.

p / k p / k

A Cascade Strategy Enables aTotal Synthesis of (±)-Morphine

S. Chu, N. Münster, T. Balan, M. D. Smith, Angew. Chem. Int. Ed. 2016, 55, 14306.

p / k p / k

Total Synthesis of (–)-Dendrobine

C.-K. Sha, R.-T. Chiu, C.-F. Yang, N.-T. Yao, W.-H. Tseng, F.-L. Liao, S.-L. Wang, J. Am. Chem. Soc. 1997, 119, 4130–4135.

p / k p / k

Total Synthesis of Cycloinumakiol

T. Xu, G. Dong, Angew. Chem. Int. Ed. 2014, 53, 10733–10736.

p / k p / k

Total Synthesis of Actinophyllic Acid

Y. Yoshii, H. Tokuyama, D. Y.-K. Chen, Angew. Chem. Int. Ed. 2017, 56, 12277–12281.

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Total Synthesis of Unsymmetrically Oxidized Nuphar Thioalkaloids via Copper-Catalyzed Thiolane Assembly

J. J. Lacharity, J. Fournier, P. Lu, A. K. Mailyan, A. T. Herrmann, A. Zakarian, J. Am. Chem. Soc. 2017, 139, 13272–13275.

p / k p / k

Total Synthesis of Septedine

S. Zhou, R. Guo, P. Yang, Ang Li, J. Am. Chem. Soc. 2018, ASAP. DOI: 10.1021/jacs.8b03712.

p / k p / k

Total Synthesis of Pyrroloazocine Indole Alkaloid Grandilodine C

F. M. Miloserdov, M. S. Kirillova, M. E. Muratore, A. M. Echavarren, J. Am. Chem. Soc. 2018, 140, 5393.

p / k p / k

Unified Total Synthesis of Madangamines A, C, and E

T. Suto, Y. Yanagita, Y. Nagashima, S. Takikawa, Y. Kurosu, N. Matsuo, T. Sato, N. Chida, J. Am. Chem. Soc. 2017, 139, 2952.

p / k p / k

Total Synthesis of (+)-Complanadine A Using an Iridium-Catalyzed Pyridine C-H Functionalization

D. F. Fischer, R. Sarpong, J. Am. Chem. Soc. 2010, 132, 5926–5927.

p / k p / k

A Concise Total Synthesis of Salinketal B

J. Liu, J. K. De Brabander, J. Am. Chem. Soc. 2009, 131, 12562.

p / k p / k

Studies on Total Synthesis of the Cytotoxic Marine Alkaloid Agelastatin A

G. T. Anderson, C. E. Chase, Y.-H. Koh, D. Stien, S. M. Weinreb, J. Org. Chem. 1998, 63, 7594.

p / k p / k

Total Synthesis of (±)-Myrocin C

M. Y. Chu-Moyer, S. J. Danishefsky, G. K. Shulte, J. Am. Chem. Soc. 1994, 116, 11213–11228.

p / k p / k

Total Syntheses of (+)- and (–)-Tetrapetalones A and C

H. H. Dhanjee, Y. Kobayashi, J. F. Buergler, T. C. McMahon, M.W. Haley, J, M. Howell, K. Fujiwara, J. L. Wood, J. Am. Chem. Soc. 2017, 139, 14901–14904.

p / k p / k

Enantioselective Total Synthesis of Mandelalide A and Isomandelalide A: Discovery of a Cytotoxic Ring-Expanded Isomer

N. Veerasamy, A. Ghosh, J. Li, K. Watanabe, J. D. Serrill, J. E. Ishmael, K. L. McPhail, R. G. Carter, J. Am. Chem. Soc. 2016, 138, 770.

p / k p / k

A General Strategy to Elisabethane Diterpoenes: Stereocontrolled Synthesis of Elisapterosin B via Oxidative Cyclization of an Elizabethin Precursor

N. Waizumi, A. R. Stankovic, V. H. Rawal, J. Am. Chem. Soc. 2003, 125, 13022–13023.

p / k p / k

A modular and enantioselective synthesis of the pleuromutilin antibiotics

S. K. Murphy, M. Zeng, S. B. Herzon, Science 2017, 356, 956–959.

p / k p / k

alpha-Ketenyl Radical Intermediates in the Synthesis of Propellanes. A Formal Synthesis of Modhephene

B. De Boeck, G. Pattenden, Tet. Lett. 1988, 39, 6975–6978.

p / k p / k

A Synthesis of Alsmaphorazine B Demonstrates the Chemical Feasibility of a New Biogenetic Hypothesis

A. Y. Hong, C. D. Vanderwal, J. Am. Chem. Soc. 2015, 137, 7306–7309.

p / k p / k

Total Syntheses of Scaparvins B, C, and D Enabled by a Key C-H Functionalization

Q.Ye, P. Qu, S. A. Snyder, J. Am. Chem. Soc. 2017, 139, 18428–18431.

p / k p / k

Total Syntheses of (–)-Majucin and (–)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes

M. L. Condakes, K. Hung, S. J. Harwood, Thomas J. Maimone, J. Am. Chem. Soc. 2017, 139, 17783–17786.

p / k p / k

Stereocontrolled total synthesis of (+)-paraherquamide B

T. D. Cushing, J. F. Sanz-Cervera, R. M. Williams, J. Am. Chem. Soc. 1993, 115, 9323–9332.

p / k p / k

Development, Mechanistic Elucidation, and Rational Optimization of a Tandem Ireland
Claisen/Cope Rearrangement Reaction for Rapid Access to the (Iso)Cyclocitrinol Core

C. W. Plummer, C. S. Wei, C. E. Yozwiak, A. Soheili, S. O. Smithback, J. L. Leighton, J. Am. Chem.
Soc. 2014, 136, 9878–9881.

p / k p / k

Total Synthesis of (–)-Xylogranatopyridine B via Palladium-Catalyzed Oxidative Stannlyation of Enones

A.W. Schuppe, D. Huang, Y. Chen, T. R. Newhouse, J. Am. Chem. Soc. 2018, 140, 2062–2066.

p / k p / k

Synthesis of Strophasterol A Guided by a Proposed Biosynthesis and Innate Reactivity

R. C. Heinze, D. Lentz, P. Heretsch, Angew. Chem. Int. Ed. 2016, 55, 11656–11659.

p / k p / k

Total Synthesis of (−)-Himalensine A

H. Shi, I. N. Michaelides, B. Darses, P. Jakubec, Q. N. N. Nguyen, R. S. Paton, D. J. Dixon, J. Am. Chem. Soc. 2017, 139, 17755–17758.

p / k p / k

Total Synthesis of (+)-Chinensiolide B

T. G. Elford, D. G. Hall, J. Am. Chem. Soc. 2010, 132, 1488–1489.

p / k p / k

Gram-Scale Enantioselective Formal Synthesis of Morphine

M. Tissot, R. J. Phipps, C. Lucas, R. M. Leon, R. D. M. Pace, T. Ngouansavanh, M. J. Gaunt
Angew. Chem. Int. Ed. 2014, 53, 13498–13501.

p / k p / k

Total Synthesis of Phomoidride D

J. C. Leung, A. A. Bedermann, J. T. Njardarson, D. A. Spiegel, G. K. Murphy, N. Hama, B. M. Twenter, P. Dong, T. Shirahata, I. M. McDonald, M. Inoue, N. Taniguchi, T. C. McMahon, C. M. Schneider, N. Tao, B. M. Stoltz, J. L. Wood, Angew. Chem. Int. Ed. 2018, 57, 1991–1994.

p / k p / k

Short, Enantioselective Total Synthesis of (+)-Chatancin

Y.-M. Zhao, T. J. Maimone, Angew. Chem. Int. Ed. 2015, 54, 1223–1226.

p / k p / k

A 11-Steps Total Synthesis of Magellanine through a Gold(I)-Catalyzed Dehydro Diels-Alder Reaction

P. McGee, G. Bétournay, F. Barabé, L. Barriault, Angew. Chem. Int. Ed. 2017, 56, 6280–6283.

p / k p / k

Total Syntheses of Dalesconol A and B

S. Snyder, T. Sherwood, A. Ross, Angew. Chem. Int. Ed. 2010, 49, 5146–5150.

p / k p / k

Total Synthesis of 4-Desmethyl-3alpha-hydroxy-15-rippertene

R. Henning, P. Metz, Angew. Chem. Int. Ed. 2009, 48, 1157–1159.

p / k p / k

Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (−)-2(S)-Cathafoline, and (−)-Aspidophylline A

J. Moreno, E. Picazo, L. A. Morrill, J. M. Smith, N. K. Garg, J. Am. Chem. Soc. 2016, 138, 1162–1165.

p / k p / k

Total Synthesis of Longeracinphyllin A

J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li, J. Am. Chem. Soc. 2017, 139, 14893–14896.

p / k p / k

Total Synthesis of (−)-Mandelalide A Exploiting Anion Relay Chemistry (ARC)

M. H. Nguyen, M. Imanishi, T. Kurogi, and A. B. Smith, III,  J. Am. Chem. Soc. 2016, 138, 3675.

p / k p / k

Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3 and (+)-11,11-Dihydroxysaxitoxin

J. V. Mulcahy, J. R. Walker, J. E. Merit, A. Whitehead, J. Du Bois, J. Am. Chem. Soc. 2016, 138, 5994−6001.

p / k p / k

Total Synthesis of (+)-Pleuromutilin

N. J. Fazakerley, M. D. Helm, D. J. Procter, Chem. Eur. J. 2013, 19, 6718–6723.

p / k p / k

Asymmetric Total Synthesis of ent-(−)-Roseophilin: Assignment of Absolute Configuration

D. L. Boger, J. Hong, J. Am. Chem. Soc. 2001, 123, 8515–8519.

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p / k

An Efficient Synthetic Approach to Cyanocycline A via [C+NC+CC] Coupling

Ü. Kaniskan, P. Garner, J. Am. Chem. Soc. 2007, 129, 15460–15461.

p / k p / k

Asymmetric Total Synthesis of Solandelactone E

A. Robinson, V. K. Aggarwal, Angew. Chem. Int. Ed. 2010, 49, 6673–6675.

p / k p / k

Total Synthesis of the Protein Phosphatase 2A Inhibitor Lactodehydrothyrsiferol

D. J. Clausen, S. Wan, P. E. Floreancing, Angew. Chem. Int. Ed. 2011, 50, 5178–5181.

p / k p / k

Enantioselective Total Synthesis of (+)-Psiguadial B

L. M. Chapman, J. C. Beck, L. Wu, S. E. Reisman, J. Am. Chem. Soc. 2016, 138, 9803–9806.

p / k p / k

Asymmetric Total Syntheses of Kopsia Indole Alkaloids

L. Leng, X. Zhou, Q. Liao, F. Wang, H. Song, D. Zhang, X. Liu, Y. Qin, Angew. Chem. Int. Ed. 2017, 56, 3703–3707.

p / k p / k

A Biomimetic Synthesis of (±)-Basiliolide B

X. Liang, L. Zhou, L. Min, W. Ye, W. Bao, W. Ma, Q. Yang, F. Qiao, X. Zhang, C.-S. Lee, Angew. Chem. Int. Ed. 2014, 53, 11294–11297.

p / k p / k

A Carbene Catalysis Strategy for the Synthesis of Protoilludane Natural Products: Total Synthesis of Armillaridin and Isovelleral

M. T. Hovey, D. T. Cohen, D. M. Walden, P. H.-Y. Cheong, K. A. Scheidt, Angew. Chem. Int. Ed. 2017, 56, 9864–9867.

p / k p / k

Total Synthesis of (−)-Dactylolide

S. Y. Yun, E. C. Hansen, I. Volchkov, E. J. Cho, W. Y. Lo, D. Lee, Angew. Chem. Int. Ed. 2010, 49, 4261–4263.

p / k p / k

Total Synthesis of (±)-spiramilactone B

H. Cheng, F.-H. Zeng, X. Yang, Y.-J. Meng, L. Xu, F.-P. Wang, Angew. Chem. Int. Ed. 2016, 55, 392–396.

p / k p / k

Biomimetic Total Synthesis of the Pentacyclic Amaryllidaceae Alkaloid Derivative Gracilamine

N. Y. Gao, M. G. Banwell, A. C. Willis, Org. Lett. 2017, 19, 162–165.

p / k p / k

Total Syntheses of Highly Oxidized ent-Kaurenoids Pharicin A, Pharicinin B, 7-O-Acetylpseurata C, and Pseurata C: A [5+2] Cascade Approach

C. He, J. Hu, Y. Wu, H. Ding, J. Am. Chem. Soc. 2017,139, 6098.

p / k p / k

Total synthesis of securinega alkaloids (−)-norsecurinine, (−)-niruroidine and (−)-flueggine A

N. Ma, Y. Yao, B.-X. Zhao, Y. Wang, W.-C. Ye, S. Jiang, Chem. Commun. 2014, 50, 9284–9287.

p / k p / k

Total Synthesis of (−)-Nakadomarin A

M. G. Nilson, R. L. Funk, Org. Lett. 2010, 12, 4912–4915.

p / k p / k

Total Synthesis of (−)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction

M. Sato, H. Azuma, A. Daigaku, S. Sato, K. Takasu, K. Okano, H. Tokuyama, Angew. Chem. Int. Ed. 2017, 56, 1087–1091.

pk  p / k

A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials

B. T. Parr, C. Economou, S. B. Herzon, Nature 2015, 525, 507–510.
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