Research Group Prof. Bernhard Kräutler

Our main research interests concern the ‘Pigments of Life’, such as heme, chlorophyll and vitamin B₁₂: their discovery, their chemical and biological synthesis, their biologically important structure and chemical reactivity, as well as their biological functions, based on which, applications in the life sciences and in medicine are investigated.

The Kräutler group is a member of the ‘Center for Molecular Biosciences Innsbruck’ (CMBI).

recent publications

Christoph Kieninger, Klaus Wurst, Maren Podewitz, Maria Stanley, Evelyne Deery, Andrew Lawrence, Klaus R. Liedl, Martin J Warren and Bernhard Kräutler
Replacement of the Cobalt-Center of Vitamin B₁₂ by Nickel - Nibalamin and Nibyric Acid Prepared from Metal-Free B₁₂-Ligands Hydrogenobalamin and Hydrogenobyric Acid
Angew. Chem. Int. Ed. 59, 20129 –20136 (2020)

Simone Moser, Theresia Erhart, Sigrid Neuhauser and Bernhard Kräutler
Phyllobilins from senescence associated chlorophyll breakdown in leaves of basil (Ocimum basilicum) show increased abundance upon herbivore attack
J. Agr. Food Chem. 68, 7132-7142 (2020)

Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B₁₂-Cofactors for Catalysis
Angew. Chem. Int. Ed. 58, 10756-10760 (2019)

Theresia Erhart, Stefan Vergeiner, Bernhard Kräutler and Thomas Müller
Chlorophyll Breakdown in a Fern – Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers
Angewandte Chemie Int. Ed., 57, 14937-14941 (2018)

Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber,
Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive,
Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016)

F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank,
K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin -
the Nonnatural Rhodium Homologue of Coenzyme B₁₂
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)

B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs
of Ripening, Senescence and Cell Death (Review)
Angew. Chem. Int. Ed., 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)

B. Kräutler
Antivitamins B₁₂ - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)

M. Ruetz, C. Gherasim, K. Gruber, S. Fedosov, R. Banerjee, B. Kräutler
Radical Synthesis Opens Access to Organometallic Aryl-Cobaltcorrins: 4-Ethylphenylcobalamin,
a Potential “Antivitamin B₁₂”
Angew. Chem. Int. Ed., 52, 2606-2610 (2013), Angew. Chem., 125, 2668-2672 (2013)

K. Gruber, B. Puffer, B. Kräutler
Vitamin B₁₂-derivates – enzyme cofactors and ligands of proteins and nucleic acids
Chem. Soc. Rev., 40, 4346 – 4363 (2011)

S. Moser, T. Müller, A. Holzinger, C. Lütz, S. Jokusch, N. J. Turro, B. Kräutler
Fluorescent chlorophyll catabolites in bananas light up blue halos of cell death
Proc. Natl. Acad. Sci., USA 106, 15538-15542 (2009)