Research Group Prof. Bernhard Kräutler

Our main research interests concern the ‘Pigments of Life’, such as heme, chlorophyll and vitamin B₁₂: their discovery, their chemical and biological synthesis, their biologically important structure and chemical reactivity, as well as their biological functions, based on which, applications in the life sciences and in medicine are investigated.

The Kräutler group is a member of the ‘Center for Molecular Biosciences Innsbruck’ (CMBI).

recent publications

Markus Ruetz, A. Shanmuganathan, Carmen Gherasim, A. Karasik, Robert Salchner, Christoph Kieninger, Klaus Wurst, Ruma Banerjee, Markos Koutmos and Bernhard Kräutler
Antivitamin B₁₂ Inhibition of Human B₁₂-Processing Enzyme CblC - Crystal Structure of Abortive Ternary Complex with Cosubstrate Glutathione
Angew. Chem. Int. Ed. 56, 7387-7392 (2017)

Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber,
Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive,
Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016)

F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank,
K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin -
the Nonnatural Rhodium Homologue of Coenzyme B₁₂
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)

B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs
of Ripening, Senescence and Cell Death (Review)
Angew. Chem. Int. Ed., 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)

B. Kräutler
Antivitamins B12 - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)

M. Ruetz, C. Gherasim, K. Gruber, S. Fedosov, R. Banerjee, B. Kräutler
Radical Synthesis Opens Access to Organometallic Aryl-Cobaltcorrins: 4-Ethylphenylcobalamin,
a Potential “Antivitamin B12”
Angew. Chem. Int. Ed., 52, 2606-2610 (2013), Angew. Chem., 125, 2668-2672 (2013)

S. Banala, R. G. Huber, T. Müller, M. Fechtel, K. R. Liedl, B. Kräutler
Porphyrin-LEGO: Synthesis of a Hexafullereno-Diporphyrin Using Porphyrins Programmed for
[4+2]-Cycloaddition
ChemComm, 48, 4359-4361 (2012)

K. Gruber, B. Puffer, B. Kräutler
Vitamin B12-derivates – enzyme cofactors and ligands of proteins and nucleic acids
Chem. Soc. Rev., 40, 4346 – 4363 (2011)

S. Moser, T. Müller, A. Holzinger, C. Lütz, S. Jokusch, N. J. Turro, B. Kräutler
Fluorescent chlorophyll catabolites in bananas light up blue halos of cell death
Proc. Natl. Acad. Sci., USA 106, 15538-15542 (2009)

S. Banala, T. Rühl, K. Wurst & B. Kräutler
'Blackening' Porphyrins by Conjugating with Quinones
Angew. Chem. Int. Ed. 48, 599-603 (2009), Angew. Chem. 121, 607-611 (2009)