Research Group Prof. Bernhard Kräutler

Our main research interests concern the ‘Pigments of Life’, such as heme, chlorophyll and vitamin B₁₂: their discovery, their chemical and biological synthesis, their biologically important structure and chemical reactivity, as well as their biological functions, based on which, applications in the life sciences and in medicine are investigated.

The Kräutler group is a member of the ‘Center for Molecular Biosciences Innsbruck’ (CMBI).

recent publications

Christoph Kieninger, Joseph A. Baker, Maren Podewitz, Klaus Wurst, Steffen Jockusch, Andrew D. Lawrence, Evelyne Deery, Karl Gruber, Klaus R. Liedl, Martin J. Warren & Bernhard Kräutler
Zinc Substitution of Cobalt in Vitamin B₁₂ - Zincobyric acid and Zincobalamin as Luminescent Structural B ₁₂-Mimics
Angew. Chem. Int. Ed. 58, 14568 –14572 (2019)

Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B₁₂-Cofactors for Catalysis
Angew. Chem. Int. Ed. 58, 10756-10760 (2019)

Theresia Erhart, Stefan Vergeiner, Bernhard Kräutler and Thomas Müller
Chlorophyll Breakdown in a Fern – Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers
Angewandte Chemie Int. Ed., 57, 14937-14941 (2018)

Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber,
Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive,
Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016)

F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank,
K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin -
the Nonnatural Rhodium Homologue of Coenzyme B₁₂
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)

B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs
of Ripening, Senescence and Cell Death (Review)
Angew. Chem. Int. Ed., 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)

B. Kräutler
Antivitamins B12 - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)

M. Ruetz, C. Gherasim, K. Gruber, S. Fedosov, R. Banerjee, B. Kräutler
Radical Synthesis Opens Access to Organometallic Aryl-Cobaltcorrins: 4-Ethylphenylcobalamin,
a Potential “Antivitamin B12”
Angew. Chem. Int. Ed., 52, 2606-2610 (2013), Angew. Chem., 125, 2668-2672 (2013)

K. Gruber, B. Puffer, B. Kräutler
Vitamin B12-derivates – enzyme cofactors and ligands of proteins and nucleic acids
Chem. Soc. Rev., 40, 4346 – 4363 (2011)

S. Moser, T. Müller, A. Holzinger, C. Lütz, S. Jokusch, N. J. Turro, B. Kräutler
Fluorescent chlorophyll catabolites in bananas light up blue halos of cell death
Proc. Natl. Acad. Sci., USA 106, 15538-15542 (2009)