Research

Resolving functional nucleic acid dynamics

Our main research interest lies on the characterization of structural and dynamic features of RNA and DNA. For that purpose we use chemo-enzymatic synthesis to produce site-specific 13C/15N/2H-modified nucleotide building blocks for chemical and enzymatic RNA and DNA synthesis. The improved labeling protocol enables to study micro- to millisecond dynamics via NMR. Using this approach functionally important states can be characterized, which are often transiently and weakly populated.

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Current Funding

Austrian Science Fund (FWF)

2017-2020
Stand alone project P30370 ‘Effect of RNA modifications on structure and dynamics probed by NMR’

2020-2023
Stand alone project P32773 ‘Expanding the NMR toolbox for integrated structural biology of nucleic acids’

Austrian Research Promotion Agency (FFG)

2017-2021
West Austrian BioNMR (funding for NMR infrastructure) link

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