Resolving functional nucleic acid dynamics

Our main research interest lies on the characterization of structural and dynamic features of RNA and DNA. For that purpose we use chemo-enzymatic synthesis to produce site-specific 13C/15N/2H-modified nucleotide building blocks for chemical and enzymatic RNA and DNA synthesis. The improved labeling protocol enables to study micro- to millisecond dynamics via NMR. Using this approach functionally important states can be characterized, which are often transiently and weakly populated.


Current Funding

Austrian Science Fund (FWF)

Stand alone project P26550 ‘Resolving excited states of a ribozyme by NMR’ 

Stand alone project P28725 ‘Seeing the invisible - excited state RNA structures’

Stand alone project P30370 ‘Effect of RNA modifications on structure and dynamics probed by NMR’

Austrian Research Promotion Agency (FFG)

West Austrian BioNMR (funding for NMR infrastructure) link