Research
Resolving functional nucleic acid dynamics
Our main research interest lies on the characterization of structural and dynamic features of RNA and DNA. For that purpose we use chemo-enzymatic synthesis to produce site-specific 13C/15N/2H-modified nucleotide building blocks for chemical and enzymatic RNA and DNA synthesis. The improved labeling protocol enables to study micro- to millisecond dynamics via NMR. Using this approach functionally important states can be characterized, which are often transiently and weakly populated.
Current Funding
Austrian Science Fund (FWF)
2016-2019
Stand alone project P28725 ‘Seeing the invisible - excited state RNA structures’
2017-2020
Stand alone project P30370 ‘Effect of RNA modifications on structure and dynamics probed by NMR’
Austrian Research Promotion Agency (FFG)
2017-2021
West Austrian BioNMR (funding for NMR infrastructure) link