Research Interests
The Zwerschke lab works on adipose tissue biology with main emphasis on molecular mechanisms underlying proliferation, differentiation and aging of adipose stem/progenitor cells (ASCs). In addition, the group studies the impact of obesity and weight-loss interventions (such as caloric restriction) on ASCs and analyses the effects of weight-loss mimetics on ASCs and adipocytes. To address our research questions, we use genomics, transcriptomics and proteomics technologies, modern techniques of molecular and cell biology including CRISPR-mediated genome editing, flow cytometry and up-to-date imaging technologies. We work with primary human cells ex vivo and in cell culture and use genetic animal models.
Keywords: Adipose Tissue Biology, Adipose Stem Cells, Adipocytes, Cellular Aging and Differentiation, Obesity, Caloric Restriction, Cancer
