20.03.2017
Novel regulator of mitochondrial function and cellular senescence uncovered
IBA researchers identified a new function of the human mitochondrial metabolic enzyme FAH domain containing protein 1 (FAHD1). Initially identified as a protein with differential expression in senescent vs. young cells, FAHD1 has recently been identified as oxaloacetate decarboxylase, the first enzyme of its kind to be found in eukaryotes. New research at IBA now establishes FAHD1 as novel regulator of senescence in human endothelial cells and pinpoints mitochondrial dysfunction as new senescence-inducing mechanism in FAHD1-depleted cells. These findings reveal a new connection between function of the mitochondrial electron transport chain and cellular senescence and reveal FAHD1 as potential target for intervention in age-related conditions.
PubMed