New findings in obesity and aging research:
Weight-loss interventions improve insulin sensitivity, protect from obesity, and postpone age-associated diseases. The impact of weight-loss on stem cells and differentiation processes is little understood. Scientists of the Zwerschke Research Group at IBA recently found that weight-loss upregulates the tumor suppressor protein Sprouty1 in adipose stem cells of white adipose tissue of formerly obese people. They further showed that Sprouty1, an inhibitor of ras-MAPK signalling, acts as negative regulator of adipogenic differentiation in the adipose stem cells. This study contributes to the better understanding of obesity and stem cell aging.
For further reading see Mandl et al., 2019 https://www.nature.com/subjects/ageing and https://www.ncbi.nlm.nih.gov/pubmed/31138786