Endogenes Dkk-3 wird zur Bildung von Drüsen in 3D Kulturen der Prostata benötigt

Peter Berger and colleagues show that Matrix metalloproteases (MMPs) play roles in the cellular responses to Dickkopf-3 during prostate epithelial cell acinar morphogenesis and TGF- β -dependent prostate cancer cell invasion. These observations highlight a role for Dkk-3 in modulating TGF-β/MMP signals in the prostate, and suggest that the Dkk-3 Cys2 domain can be used as a basis for therapies that target the tumor promoting effects of TGF-β signaling in advanced prostate cancer.