11.01.2016
Endogenes Dkk-3 wird zur Bildung von Drüsen in 3D Kulturen der Prostata benötigt
Peter Berger and colleagues show that
Matrix metalloproteases (MMPs)
play roles in the cellular responses to Dickkopf-3 during prostate epithelial cell acinar morphogenesis and TGF-
β
-dependent prostate cancer cell invasion.
These observations highlight a role for Dkk-3 in modulating TGF-β/MMP signals in the prostate, and suggest that the Dkk-3 Cys2 domain can be used as a basis for therapies that target the tumor promoting effects of TGF-β signaling in advanced prostate cancer.
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