IBA researchers identify the new mechanism of prostate carcinogenesis

Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of male cancer death in Western nations, therefore the new treatment modalities are urgently needed. The group of enzymes NADPH oxidases (Nox) represent the major non-mitochondrial sources of intracellular reactive oxygen species (ROS). Nox enzymes in conjunction with NADPH oxidation, reduce molecular oxygen to superoxide. Although ROS generated by the Nox has been implicated in prostate tumorigenesis, the identity of the Nox enzyme(s) remained unknown. IBA researchers in collaboration with the Department of Urology at the Medical University of Innsbruck identify elevated production of ROS by NADPH oxidase 5 (Nox5) as an important mediator of prostate tumorigenesis. PubMed