Lepperdinger EXG 2012 | Reitinger&Lepperdinger Gerontology 2012 | Reitinger BIOS 2012 | Kloss et al Head and Neck J Sci Spec 2012 | Jamnig&Lepperdinger Can J Physiol Pharmacol 2012 | Singh et al J Cell Mol Med 2012 | Herndler-Brandstetter et al J Leukoc Biol 2012 | Wissenwasseret al Rev Sci Instrum 2011 | Ilias et al J Biol Chem. 2011 | Lepperdinger Curr Opin Immunol 2011 | Landgraf et al Transpl Immunol 2011 | Lepperdinger In: “Adult Progenitor Cell Standardization” | Brunauer et al In: "Cell Aging" | Stemberger et al Plos One 2011 | Laschober et al Rejuv Res 2011 | Hofer et al BMC Genomics 2011 | Odörfer et al J Cell Mol Med 2011 | Herndler-Brandstetter et al Human Immunol 2011 | Herndler-Brandstetter et al J Immuol 2011 | Wagner et al Aging 2010 | Fuellen et al Rejuv Res 2010 | Laschober et al Aging Cell 2010 | Hackl et al Aging Cell 2010 | Lepperdinger et al In: “Stem Cell Engineering, Principles & Applications” | Reitinger et al J Biol Chem 2009 | Lazuardi et al Biogerontology 2009 | Lepperdinger et al Gerontology 2009 | Laschober et al Exp Gerontol 2009 | Mayr et al Advances in Bioinformatics 2008 | Schraml et al Gerontology 2008 | Lepperdinger Exp Gerontol 2008 | Lepperdinger et al Exp Gerontol 2008 | Lepperdinger et al Transfus Med Hemother 2008 | Lepperdinger et al Front Biosci 2008 | Herndler-Brandstetter et al Biol Chem 2008 | Reitinger et al Protein Expr Purif 2008 | Schwanninger et al Immunity & Ageing 2008 | Kloss et al Biomaterials 2008 | Kloss et al J Nanosci Nanotechnol 2007 | Fehrer et al Aging Cell 2007 | Reitinger et al Biochem J 2007

List of Publication (2007-)

  1. Lepperdinger G. Developmental programs are kept alive during adulthood by stem cells: The aging aspect. Experimental Gerontology, accepted
  2. Reitinger, St. Lepperdinger G. Hyaluronan, a ready choice to fuel regeneration. Gerontology, accepted
  3. Reitinger S., Wissenwasser J., Kapferer W., Heer R., Lepperdinger G. Electric impedance sensing in cell-substrates for rapid and selective multipotential differentiation capacity monitoring of human mesenchymal stem cells. Biosens Bioelectron, 2012;34(1):63-69.
  4. Kloss, F.R.; Singh, S., Hächl, O., Rentenberger, J., Kraft, A., Franzelin, M., Smeets, R., Klima, G., Mitterlechner, T., Steinmüller-Nethl, D., Lepperdinger, G., Rasse, M., Gassner. R. Responsiveness of bone to immobilized BMP-2 after irradiation – an in vivo investigation. Head and Neck J Sci Spec 2012 Mar 11. doi: 10.1002/hed.22958. [Epub ahead of print]
  5. Jamnig A., Lepperdinger G. From tendon to nerve: An MSC for all seasons. Can J Physiol Pharmacol 2012;90(3):295-306.
  6. Singh S., Kloss F., Brunauer R., Jamnig A., Greiderer B., Klima G., Rentenberger J., Auberger T., Rasse M., Gassner R., Lepperdinger G. Mesenchymal stem cells show high radioresistance in vivo. J Cell Mol Med 2012;16(4):877-887.
  7. Herndler-Brandstetter D., Landgraf K., Tzankov A., Jenewein B., Brunauer R., Laschober G.T., Parson W., Kloss F., Gassner R. Lepperdinger G., Grubeck-Loebenstein B. The impact of aging on memory T cell phenotype and function in the human bone marrow. J Leukoc Biol 2012;91:197-205.
  8. Wissenwasser J., Vellekoop M.J., Kapferer W., Lepperdinger G., Heer R. Multifrequency impedance measurement technique for wireless characterization of microbiological cell cultures. Rev Sci Instrum 2011;82:115110.
  9. Ilias A., Liliom K., Greiderer-Kleinlercher B., Reitinger S., Lepperdinger G. Unbinding of hyaluronan accelerates the enzymatic activity of bee hyaluronidase. J Biol Chem. 2011;286:35699-35707.
  10. Lepperdinger G. Inflammation and mesenchymal stem cell aging. Curr Opin Immunol 2011;23:518–524.
  11. Landgraf K., Brunauer R., Lepperdinger G., Grubeck-Loebenstein B. The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age. Transpl Immunol 2011;25:167-172.
  12. Lepperdinger G. Aging of human bone-derived mesenchymal stem cells in their niche. In: “Adult Progenitor Cell Standardization”. Paolo DiNardo (ed.), River Publishers, 2011, pp 167-182. ISBN 978-87-92329-74-5.
  13. Brunauer R., Reitinger S., Lepperdinger G. Agelessness of mesenchymal stem cells. In: "Cell Aging". Perloft J.W., Wong A.H. (eds.) Nova Science Publishers, New York, 2011, pp 215-240. ISBN 978-1-61324-369-5.
  14. Stemberger S., Stefanova N., Jamnig A., Lepperdinger G., Reindl M., Wenning G.K. Mesenchymal stem cells in a transgenic animal model of multiple system atrophy: Immunomodulation and neuroprotection. Plos One 2011;6(5):e19808.
  15. Laschober G., Brunauer R., Jamnig A., Sing S., Hafen U., Fehrer C., Kloss F., Gassner R., Lepperdinger G. Age-specific changes of mesenchymal stem cells are paralleled by upregulation of CD106 expression as a response to an inflammatory environment. Rejuv Res 2011;14(2):119-131.
  16. Hofer E., Laschober G.T., Hackl M., Thallinger G.G., Lepperdinger G., Grillari J., Jansen-Dürr P., Trajanoski Z. GiSAO.db: A database for ageing research. BMC Genomics 2011;12:262.
  17. Odörfer Kl, Egerbacher M, Unger NJ, Weber K, Jamnig A, Lepperdinger G, Kleiter M, Sandgren EP, Erben RG. Hematopoietic bone marrow cells participate in endothelial, but not epithelial or mesenchymal cell renewal in adult rats. J Cell Mol Med 2011;15:2232-2244.
  18. Herndler-Brandstetter D., Brunner S., Weiskopf D., van Rijn R., Landgraf K., Dejaco C., Duftner C., Schirmer M., Kloss F., Gassner R., Lepperdinger G., Grubeck-Loebenstein B. Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to IL-15. Human Immunol 2011;72:627-631.
  19. Herndler-Brandstetter D., Landgraf K., Jenewein B., Tzankov A., Brunauer R., Brunner S., Parson W., Kloss F., Gassner R., Lepperdinger G., Grubeck-Loebenstein B. Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells. J Immunol 2011;15;186(12):6965-6971.
  20. Wagner W, Bork S, Lepperdinger G, Joussen S, Ma N, Strunk D, Koch C. How to track cellular aging of mesenchymal stromal cells? Aging (Albany NY) 2010;2:224-230 
  21. Fuellen G., Adjaye J., de Grey A., Lepperdinger G., de Magalhães J.P., Sühnel J., Wipat A. Bioinformatics in aging research: A workshop report. Rejuv Res 2010;13:763-767 
  22. Laschober G.T., Ruli D., Hofer E., Mück C., Carmona-Gutierrez D., Ring J., Hütter E., Ruckenstuhl C., Micutkova L, Brunauer R., Jamnig A., Trimmel D., Herndler-Brandstetter D., Brunner S., Zenzmaier C., Samspon N. Breitenbach M., Fröhlich K-U., Grubeck-Loebenstein B., Berger P., Wieser M., Grillari-Voglauer R., Thallinger G.G., Grillari, J., Trajanoski Z., Madeo F., Lepperdinger G., Jansen-Dürr P. Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell 2010;9:1084-1097 Doi: 10.1111/j.1474-9726.2010.00637.x
  23. Hackl M., Brunner S., Fortschegger K. Schreiner C., Micutkova L., Mück C., Laschober G., Lepperdinger G., Sampson N., Berger P., Herndler-Brandstetter D., Wieser M., Kühnel H., Strasser A., Rinnerthaler M., Breitenbach M., Mildner C., Eckhard L., Tschachler E., Trost A., Bauer J.W., Papak C., Trajanoski Z., Scheideler M., Grillari-Voglauer R., Grubeck-Loebenstein B., Jansen-Dürr P., Grillari J. miR-17, miR-19b, miR-20a and miR-106a are down-regulated in human aging. Aging Cell 2010;9:291-296 doi: 10.1111/j.1474-9726.2010.00549.x
  24. Lepperdinger G., Singh S., Kloss F. Responses of MSC to varying oxygen availability in vitro and in vivo. In: “Stem Cell Engineering, Principles & Applications” (eds. Artmann G.M., Hescheler J., Minger St.) 2010 pp. 199-211
  25. Reitinger S., Müllegger J., Greiderer B., Nielsen J.E., Lepperdinger G. Designed human serum hyaluronidase 1 variant, HYAL1L, exhibits activity up to pH 5.9. J Biol Chem 2009;284:19173-19177.
  26. Lazuardi L., Herndler-Brandstetter D., Brunner S., Laschober G.T., Lepperdinger G., Grubeck-Loebenstein B. Microarray analysis reveals similarity between CD8+CD28- T cells from young and elderly persons, but not of CD8+CD28+ T cells. Biogerontology 2009;10:191-202.
  27. Lepperdinger G. Open-ended question: Is immortality exclusively inherent to the germline? - A mini-review. Gerontology 2009;55:114-117
  28. Laschober, G., Brunauer, R., Jamnig, A., Fehrer, C., Greiderer, B., Lepperdinger, G. Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing age and distinctly marks the subpopulation of dying cells. Exp Gerontol 2009;44:57-62.
  29. Mayr G., Lepperdinger G., Lackner, P. Automated quantitative assessment of proteins’ biological function in protein knowledge bases. Advances in Bioinformatics 2008;1:1-7; Article ID 897019, doi:10.1155/2008/897019
  30. Schwanninger A., Weinberger B.,  Weiskopf D., Herndler-Brandstetter D., Reitinger S., Gassner C., Schennach H., Parson W., Würzner R., Grubeck-Loebenstein B. Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults. Immunity & Ageing 2008, 5:14. doi:10.1186/1742-4933-5-14
  31. Schraml E., Fehrer C., Brunauer R., Lepperdinger G., Chesnokova V., Schauenstein K. lin-Sca-1+ cells and age-dependent changes of their proliferation potential are reliant on mesenchymal stromal cells and are leukemia inhibitory factor dependent. Gerontology 2008;54:312-323.
  32. Lepperdinger G. Aging stem cells and regenerative biomedicine: Concepts, opportunities and technological advances. Exp Gerontol 2008;43:967. doi:10.1016/j.exger.2008.09.004
  33. Lepperdinger G., Brunauer R., Jamnig A, Laschober G.T., Kassem M. Controversial Issue: Is it safe to employ mesenchymal stem cells in cell-based therapies? Exp Gerontol 2008;43:1018–1023.
  34. Lepperdinger G., Brunauer R., Gassner R., Jamnig A., Kloss F., Laschober G.T. Changes of the functional capacity of mesenchymal stem cells due to aging or age-associated disease: Implications for clinical applications and donor recruitment. Transfus Med Hemother 2008;35:299-305
  35. Lepperdinger G., Berger P., Breitenbach M., Fröhlich K.U., Grillari J., Grubeck-Loebenstein B., Madeo F., Minois N., Zwerschke W., Jansen-Dürr P. The use of genetically engineered model systems for research on human aging. Front Biosci 2008;13:7022-7031.
  36. Herndler-Brandstetter D., Veel E., Laschober G.T., Pfister G.,  Brunner S., Walcher S., Parson W., Lepperdinger G., Grubeck-Loebenstein B.  Non-regulatory CD8+CD45RO+CD25+ T lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T cells in old age. Biol Chem 2008;389:561-568.
  37. Reitinger S., Boroviak T., Laschober G.T., Fehrer C., Müllegger J., Lindner H., Lepperdinger G.  High-yield recombinant expression of the extremophile enzyme, bee hyaluronidase in Pichia pastoris. Protein Expr Purif 2008;57:226-233.
  38. Kloss F.R., Gassner R., Preiner J., Ebner A., Larsson K., Hächl O., Tuli T., Rasse M., Moser D., Laimer K., Nickel E.A., Laschober G., Brunauer R., Klima G., Hinterdorfer P., Steinmüller-Nethl D., Lepperdinger G. The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation. Biomaterials 2008;29:2433-2442.
  39. Kloss F.R., Najam-Ul-Haq M., Rainer M., Gassner R., Lepperdinger G., Huck C.W., Bonn G., Klauser F., Liu X., Memmel N., Bertel E., Steinmüller-Nethl D.  Nano-crystalline diamond - an excellent platform for life science applications. J Nanosci Nanotechnol 2007;7:4581-4587.
  40. Lepperdinger G. Altern Stammzellen? Jungbrunnen oder bloßes Wunschdenken (Do stem cells age? Fountain of Youth or Wishful Thinking. Biologie in unserer Zeit. Invited article. Biologie in unserer Zeit 2007;37:184-189.
  41. Fehrer C., Brunauer R., Laschober G., Unterluggauer H., Reitinger S., Kloss F., Gülly C., Gaßner R., Lepperdinger G.  Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 2007;6:745–757.
  42. Reitinger S., Laschober G.T., Fehrer C., Greiderer B., Lepperdinger G.  Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan. Biochem J 2007;401:79–85
  43. Lepperdinger, G., Laschober, G., Brunauer, R., Greiderer, B., Reitinger, St., Fehrer, C. Are stem cells growing (you) old – why (not) hesitating to apply them in the clinics. Book chapter “Impact in Ageing: a common challenge for Europe and Asia”, edited by G. Jones, S. Linhart, K. Hirokawa, G. Sinigoj, LIT Publ Int. (2007)