Publications

Original Papers (PubMed)

  1. Reitinger, St., Wissenswasser, J., Kapferer, W., Heer, R., Lepperdinger, G. Electric cell-substrate impedance sensing for rapid and selective monitoring of the multipotential differentiation capacity in human mesenchymal stem cells. Biosensors and Bioelectronics 34, 63-9 (2012) (IF2010 5.361)
  2. Kloss, F.R.; Singh, S., Hächl, O., Rentenberger, J., Kraft, A., Franzelin, M., Smeets, R., Klima, G., Mitterlechner, T., Steinmüller-Nethl, D., Lepperdinger, G., Rasse, M., Gassner. R. Responsiveness of bone to immobilized BMP-2 after irradiation – an in vivo investigation. Head and Neck J Sci Spec 2012 Mar 11. doi: 10.1002/hed.22958. [Epub ahead of print] (IF2010 2.182)
  3. Iliás, A., Liliom, K., Greiderer-Kleinlercher, B., Reitinger, St., Lepperdinger, G. Unbinding of hyaluronan accelerates the enzymatic acitivity of bee hyaluronidase. J. Biol. Chem. 286, 35699-707 (2011) (IF2010: 5.328)
  4. Herndler-Brandstetter, D., Landgraf, K., Tzankov, A., Jenewein, B., Brunauer, R., Parson, W., Kloss, F., Gassner, R., Lepperdinger, G., Grubeck-Loebenstein, B. The impact of aging on memory T cell phenotype and function in the human bone marrow. J. Leuk. Biol. 91, 197-205 (2011) (IF2010: 4.626)
  5. Wissenwasser, J., Vellekoop, M., Kapferer, W., Lepperdinger, G., Heer, R. Multifrequency Impedance Measurement Technique for Wireless Characterization of Microbiological Cell Cultures Review of Scientific Instruments 82, 115110 (2011) (IF2010 1.601)
  6. Singh, S., Kloss, F., Brunauer, R., Schimke, M., Jamnig, A., Greiderer, B., Klima, G., Rentenberger, J., Auberger, T., Rasse, M., Gassner, R., Lepperdinger, G. Mesenchymal stem cells show high radioprotective activity in vivo. J Cell. Mol. Med. 16, 877-87 (2011) (IF2010 4.608)
  7. Landgraf, K., Brunauer, R., Lepperdinger, G. Grubeck-Loebenstein, B.  The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age. Transplant Immunology 25, 167-172 (2011) (IF2010 1.912)
  8. Hofer, E. Laschober, G.T., Hackl,M., Thallinger, G.G., Lepperdinger, G., Jansen-Dürr, P., Trajanoski, Z. GISAO.db: a database for ageing research. BMC Genomics 12, 262 (2011) (IF2010 4.206)
  9. Herndler-Brandstetter, D., Landgraf, K., Jenewein, B., Tzankov, A., Brunauer, R., Parson, W., Kloss, F., Gassner, R., Lepperdinger, G., Grubeck-Loebenstein, B. Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells J. Immunol. 186, 6965-71 (2011) (IF2010 5.745)
  10. Stemberger, S., Stefanova, N., Jamnig, A., Lepperdinger, G., Reindl, M., Wenning, G.K. Mesenchymal stem cells in a transgenic animal model of multiple system atrophy: immunomodulation and neuroprotection PLOS ONE 6, e19808 (2011) (IF2010 4.411)
  11. Herndler-Brandstetter, D., Brunner., St., Weiskopf., D., van Rijn, R., Landgraf, K., Dejaco, C., Duftner, C., Schirmer, M., Kloss, F., Gassner, R., Lepperdinger, G., Grubeck-Loebenstein. B. Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to IL-15. Human Immunology 72, 627-631 (2011) (IF2010 2.872)
  12. Laschober, G.*, Brunauer, R.*, Jamnig, A., Singh, S., Hafen, U., Fehrer, C., Kloss, F., Gaßner, R., Lepperdinger, G. Age-specific changes regarding osteogenesis of mesenchymal stem cells are paralleled by upregulation of VCAM1/CD106 expression as a response to an inflammatory environment. Rejuv. Res. 14, 119-31 (2011)(IF2010 4.225)
  13. Odörfer, K.I., Egerbacher, M., Unger, N.J., Weber,. K., Jamnig, A., Lepperdinger , G., Kleiter, M., Sandgren, E.P., Erben, R.G. Hematopoietic bone marrow cells participate in endothelial, but not epithelial or mesenchymal cell renewal in adult rats, .J Cell. Mol. Med. 15, 2232-2244 (2011) (IF2010 4.608)
  14. Laschober, G.*, Ruli, D.*, Hofer, E., Carmona-Gutierrez, D., Ring, J., Hutter, E., Mück, C., Ruckenstuhl, C., Micutkova, L., Brunauer, R., Jamnig, A., Trimmel, D., Herndler-Brandstetter, D., Sampson, N., Breitenbach, M., Fröhlich, K. U., Grubeck-Loebenstein, B, Berger, P., Wieser, M., Grillari-Voglauer, R., Thallinger, G., Grillari, J., Trajanoski, Z., Madeo, F., Lepperdinger, G., Jansen-Dürr, P. Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell 9, 1084-97 (2010)(IF2010 7.148)
  15. Hackl, M.*, Brunner, S.*, Fortschegger, K., Schreiner, C., Micutkova, L., Mück, C., Laschober, G.T., Lepperdinger, G., Sampson, N., Berger, P., Herndler-Brandstätter, D., Wieser, M., Kühnel, H., Strasser, A., Rinnerthaler, M., Breitenbach, M., Mildner, M., Eckhart, L., Tschachler, E., Trost, A., Bauer, J.W., Papak, C., Trajanoski, Z., Scheideler. M., Grillari-Voglauer, R., Grubeck-Loebenstein, B., Jansen-Dürr, P., Grillari, J. miR-17, miR-19b, miR-20a and miR-106a are down-regulated in human aging. Aging Cell 9, 291-6 (2010) (IF2010 7.148) 
  16. Reitinger, St., Müllegger, J., Greiderer, B., Nielsen, J.E., Lepperdinger, G. Designed human serum hyaluronidase 1 variant, HYAL1L exhibits activity up to pH 5.9. J. Biol. Chem. 284, 19173-7 (2009) (IF2009: 5.328)
  17. Laschober, G., Brunauer, R., Jamnig, A., Fehrer, C., Greiderer, B., Lepperdinger, G. Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing age and distinctly marks the subpopulation of dying cells. Experimental Gerontology 44, 57-62 (2009) (IF2009: 3.342)
  18. Kloss, F.R., Gassner, R., Preiner, J., Ebner, A., Larsson, K., Hächl, O., Tuli, T., Rasse, M., Moser, D., Laimer, K., Nickel, E.A., Laschober, G., Brunauer, R., Schreck, M., Klima, G., Hinterdorfer, P., Steinmüller-Nethl, D., Lepperdinger, G. The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone regeneration Biomaterials 29, 2433-42 (2008) (IF2008: 7.365)
  19. Herndler-Brandstetter, D., Veel, E., Laschober, G., Pfister, G., Brunner, St., Walcher,. S., Parson, W., Lepperdinger, G., Grubeck-Loebenstein, B. A non-regulatory CD8+CD45RO+CD25+ T lymphocyte may compensate for the loss of antigen-inexperienced CD8+CD45RO+ T cells in old age. Biol. Chem. 389, 561-68 (2008) (IF2008: 3.035)
  20. Reitinger, St., Boroviak, T., Laschober, G.T., Fehrer, C., Müllegger, J., Lindner, H., Lepperdinger, G. High-yield recombinant expression of the extremophile enzyme, bee hyaluronidase in Pichia pastoris. Protein, Expression & Purification 57, 226-33 (2008) (IF2008: 1.621)
  21. Mayr, G.*, Lepperdinger, G.*, Lackner, P. T Quantitative assessment of proteins’ biological function Advances in Bioinformatics 1, 1-7 (2008) DOI:10.1155/2008/897019
  22. Schraml, E., Fehrer, C., Brunauer, R., Lepperdinger, G., Chesnokova, V., Schauenstein, K. Hematopoietic stem cells and age-dependent changes of their proliferation potential are reliant on MSC in a LIF-dependent manner. Gerontology 54,312-23 (2008) (IF2008: 1.758)
  23. Fehrer, C*., Brunauer, R.*, Laschober, G., Unterluggauer, H., Reitinger, S., Kloss, F., Gülly, C., Gaßner, R., Lepperdinger, G. Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their life span. Aging Cell 6, 745-57 (2007) (IF2008: 7.791)
  24. Reitinger, St., Laschober, G., Fehrer, C., Greiderer, B., Lepperdinger, G. Mouse Spermatocyte Hyaluronidase-Like Proteins, PH-20, Hyal5 but not HyalP1 are Degrading Hyaluronan at Physiological Conditions. Biochem. J. 401, 79-85 (2007) (IF2007: 4.009)
  25. Kloss, F.R., Najam-Ul-Haj, M., Rainer, M., Gaßner, R. Lepperdinger, G., Huck, C., Bonn, G., Klauser, F., Liu, X., Memmel, N., Bertel, E., Garrido, J.A., Steinmüller-Nethl, D. Nano-crystalline diamond – an excellent platform for life science applications. J. Nanosci. Nanotechno. 7, 4581-4587 (2007) (IF2007: 1.987)
  26. Steinmüller-Nethl, D., Kloss, F.R., Najam-Ul-Haj, M., Rainer, M., Larsson, K., Linsmeier, C., Köhler, G., Gaßner, R., Fehrer, C., Lepperdinger, G., Huck, C., Bonn, G. Strong physisorption of BMP-2 on nanocrystalline diamond retains bioactivity. Biomaterials 27; 4547-4556 (2006) (IF2006: 5.196)
  27. Fehrer, C., Laschober, G. Lepperdinger, G. Aging of Murine Mesenchymal Stem Cells. Ann N Y Acad Sci. 1067; 235-242 (2006) (IF2006: 1.930)
  28. Fehrer, C., Voglauer, R., Wieser, M., Pfister, G., Brunauer, R., Cioca, D., Grubeck-Loebenstein, B., Lepperdinger, G. Telomere Length and Telomerase Assessment. Experimental Gerontology 41: 648-651 (2006) (IF2006: 2.930)
  29. Hampel, B., Fortschegger, K., Ressler, S., Chang, M.W.F., Unterluggauer, H., Breitwieser, A., Sommergruber, W., Fitzky, B., Lepperdinger, G., Jansen-Dürr, P., Voglauer, R., Grillari, J. Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence. Experimental Gerontology 41; 474-481 (2006) (IF2006: 2.930)
  30. Herndler-Brandstetter*, D., Schwaiger, S.*, Veel, E., Fehrer, C., Cioca, D., Almanzar, G., Keller, M., Pfister, G., Parson., W., Würzner, R., Schönitzer, D., Henson, S., Aspinall, R., Lepperdinger, G., Grubeck-Loebenstein, B. CD25 expressing CD8+ T cells are potent memory cells in old age. J. Immunology 175: 1566 - 1574 (2005) (IF2005: 6.387)
  31. Untergasser, G., Gander, R., Lilg, C., Lepperdinger, G., Plas, E., Berger, P. Molecular Targets for Differentiation of Adult Human Prostate Fibroblasts into Reactive Stroma. Mech. Dev. Aging. 126: 59-69. (2005) (IF2005: 2.812)
  32. Müllegger, J.,* Rustom, A.,* Kreil, G., Gerdes H.H., Lepperdinger, G. Piggy-Back Transport of Xenopus Hyaluronan Synthase (XHAS1) via the Secretory Pathway to the Plasma Membrane. Biol. Chem. 384: 175–182 (2003) (IF2003: 3.366)
  33. Kaser, A. Winklmayr, M. Lepperdinger, G. Kreil. G. The AVIT family, secreted cysteine-rich vertebrate proteins with diverse functions EMBO Rep. 4: 469-73 (2003) (IF2003: 7.390)
  34. Müllegger, J., Lepperdinger, G. Hyaluronan is an Abundant Constituent of the Extracellular Matrix of Developing Xenopus Embryos. Mol. Rep. Dev. 61: 312-316 (2002) (IF2002: 2.322)
  35. Müllegger J., Lepperdinger, G. Degradation of hyaluronan-enriched extracellular matrix by Hyal2-type hyaluronidase effects pattern formation of vitelline vessels during embryogenesis of Xenopus laevis. Mech. Dev. 111: 25-35 (2002) (IF2002: 3.326)
  36. Sander, V., Müllegger, J., Lepperdinger, G. Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. Mech. Dev. 102: 251-253 (2001) (IF2001: 3.687)
  37. Müllegger, J., Reitinger, S., Lepperdinger, G. Hapten-labeled hyaluronan, a substrate to monitor hyaluronidase activity by enhanced chemoluminescence-assisted detection on filter blots. Anal. Biochem. 293: 291-293 (2001) (IF2001: 2.019)
  38. Melchiorri, D., Bruno, V., Besong, G., Ngomba, R.T., Cuomo, L., De Blasi, A., Copani, A, Moschella, C., Storto, M., Nicoletti, F., Lepperdinger, G., Passarelli, F. The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways. Eur. J. Neurosci. 13: 1694-1702 (2001) (IF2001: 3.919)
  39. Reitinger, St.,* Müllegger, J.,* Lepperdinger, G. Xenopus Kidney Hyaluronidase-1 (XKH1), a novel type of membrane-bound hyaluronidase degrades hyaluronan exclusively at neutral pH. FEBS Lett. 505: 213-216 (2001) (IF2001: 3.644)
  40. Kaser, A., Bogengruber, E., Hallegger, M. Doppler, E. Lepperdinger, G. Jantsch, M., Breitenbach, M., Kreil, G. Brix and Brx1, homologous proteins from Xenopus laevis and yeast, are essential for the biogenesis of the large ribosomal subunit. Biol. Chem. 382: 1637-1647 (2001) (IF2001: 2.606)
  41. Köprunner, M.,* Müllegger, J.,* Lepperdinger, G. Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis. Mech. Dev. 90: 275-278 (2000) (IF2000: 4.154)
  42. Jilek, A., Engel, E., Beier, D., Lepperdinger, G. Murine Bv8 gene maps at a synteny breakpoint between the human and mouse genome on chromosome 6. Gene 256: 189-195 (2000) (IF2000: 2.461)
  43. Li, Y., Rahmanian, M., Widström, C., Lepperdinger, G., Frost, G.I., Heldin, P. Regulation of Rat HAS2 and HYAL2 Genes in Lung Tissue Injured by Irradiation Accompanies Active Turnover of Hyaluronan and Induction of Expression of Type I and III Collagen Genes. Am. J. Resp. Cell Mol. Biol. 23: 411-418 (2000) (IF2000: 4.353)
  44. Wechselberger, C., Puglisi, R., Engel, E., Lepperdinger, G., Boitani, C., Kreil G. The mammalian homologue of Bv8 from frog skin is mainly expressed in spermatocytes. FEBS Lett. 462: 177-181 (1999) (IF1999: 3.720)
  45. Novak, U., Stylli, S. S., Kaye, A. H., Lepperdinger, G. Hyaluronidase-2 over-expression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma. Cancer Res. 59: 6246-50 (1999) (IF1999: 8.614)
  46. Lepperdinger, G., Strobl, B., Kreil, G. HYAL2, a human gene expressed in many cells which encodes a lysosomal hyaluronidase with a novel type of specificity. J. Biol. Chem. 273: 22466-22470 (1998) (IF1998: 7.199)
  47. Strobl, B., Wechselberger, C., Beier D., Lepperdinger, G. Structural organization and chromosomal localization of a lysosomal hyaluronidase encoding gene, Hyal2. Genomics 53: 214-219 (1998) (IF1998: 3.489)
  48. Schrama, L.H.,* Lepperdinger, G.,* Moritz, A., Van den Engel, N. K., Marquart, A., Oestreicher, A. B., Eggen, B. J. L., Hage, W. J., Richter, K., Destree, O. H. J. B-50/growth-associated protein-43, a marker of neural development in Xenopus laevis. Neuroscience 76: 635-652 (1997) (IF1997: 3.594)
  49. Lepperdinger, G., Engel, E., Richter, K. A retinoid-binding lipocalin, Xlcpl1, relevant for embryonic pattern formation is expressed in the nervous system of Xenopus laevis. Dev. Genes & Evol. 207: 177-185 (1997) (IF1997: 1.231)
  50. Lepperdinger, G., Strobl, B., Jilek, A., Weber, A., Thalhamer, J., Flöckner, H., Mollay, C. The lipocalin Xlcpl1 expressed in the neural plate of Xenopus laevis embryos is a secreted retinaldehyde binding protein. Protein Science 5: 1250-1260 (1996) (IF1996: 4.867)


Review Articles

  1. Lepperdinger G. Developmental programs are kept alive during adulthood by stem cells: The aging aspect. Experimental Gerontology, accepted (IF2010: 3.804)
  2. Reitinger, St. Lepperdinger G. Hyaluronan, a ready choice to fuel regeneration. Gerontology, accepted (IF2011: 2.777)
  3. Lepperdinger, G. Inflammation and mesenchymal stem cell aging. Curr. Opin. Immunol. 23, 518-24 (2011) (IF2009: 10.881)
  4. Jamnig, A., Lepperdinger, G. From tendon to nerve: an MSC for all seasons. Can. J. Physiol. Pharmacol. 90, 295-306 (2011) (IF2010: 1.849)
  5. Lepperdinger, G. Open-ended question: is immortality exclusively inherent to the germ line? Gerontology 55, 114-7 (2008) (IF2008: 1.669)
  6. Lepperdinger, G., Regina Brunauer, Angelika Jamnig, Gerhard T. Laschober Kassem, M. Controversial Issue: Is it safe to employ in vitro propagated, aged mesenchymal stem cells in cell-based therapies? Experimental Gerontology 43, 1018-1023 (2008) (IF2008: 3.382)
  7. Lepperdinger, G., Brunauer, R., Gassner, R., Jamnig, A., Kloss, F., Laschober, G.T. Changes of the Functional Capacity of Mesenchymal Stem Cells due to Aging or Age-Associated Disease: Implications for Clinical Applications and Donor Recruitment Transfusion Medicine and Hemotherapy, special issue "Recovery and Clinical Use of Mesenchymal Stem Cells according to Good Manufacturing Practice". 35, 299-305 (2008) (IF2008: 1.659)
  8. Lepperdinger, G., Berger, P., Breitenbach, M., Fröhlich, K-U., Grillari, J., Grubeck-Loebenstein, B., Madeo, F., Minois, N., Zwerschke, W., Jansen-Dürr, P. The use of genetically engineered model systems for research on human aging. Frontiers in Bioscience 13: 7022-31 (2008) (IF2008: 3.308)
  9. Fehrer, C., Lepperdinger, G. Mesenchymal Stem Cell Aging. Experimental Gerontology 40: 926-930 (2006) (IF2006: 2.930)
  10. Lackner, P., Müllegger, J., Reitinger, S., Lepperdinger, G. "Tailor-made recombinant proteins: from computational analysis to practical application" Recent Research Developments in Proteins 1: 289-315 (2002) 
  11. Lepperdinger, G., Müllegger, J., Kreil, G. HYAL2, less active but more versatile. Matrix Biology 20: 509-514 (2001) (IF2001: 3.125)
  12. Lepperdinger, G. The amphibian lipocalin, Xlcpl1: A retinoid transporter during early embryogenesis and pattern formation. BBA 1482: 119-126 (2000) (IF2000:1.399)


Editorials, Perspectives

  1. Wagner, W., Bork, S., Lepperdinger, G., Joussen, S., Ma, N., Strunk, D., Koch, C. How to Track Cellular Aging of Mesenchymal Stromal Cells? Aging 2, 224-30. (2010) 
  2. Fuellen, G., Adjaye, J., de Grey, A., Lepperdinger, G., de Magalhaes, J.P., Sühnel, J., Wipat, A. Bioinformatics in Ageing Research – a Workshop Report Rejuv. Res. (2010) (IF2009 4.138)
  3. Lepperdinger, G. Aging Stem Cells and Regenerative Biomedicine: Concepts, Opportunities and Technological Advances Guest Editors Editorial for Special Issue: “Stem Cell Aging and Regenerative Medicine” Experimental Gerontology 43 (11): 967 (2008) (IF2007: 2.879)


Book Chapters

  1. Klepsch, S., Jamnig, A., Trimmel, D., Schimke, M., Kapferer, W., Brunauer, R., Singh,S., Reitinger, S., Lepperdinger, G. Isolation of mesenchymal stem cells from human bone and long-term cultivation under physiologic oxygen condistions. Methods in Molecular Biology, Humana Press Inc., Totawa, New Jersey accepted (2012)
  2. Brunauer, R., Reitinger, St., Lepperdinger, G. Agelesseness of Mesenchymal Stem Cells. In “Cell Aging”, (ed Jack W. Perloft and Alexander H. Wong) Nova Science Publishers. ISBN: 978-1-61324-369-5 (2011)
  3. Lepperdinger, G. Aging of human bone-derived mesenchymal stem cells in their niche. In “Standardization of Mesenchymal Progenitor Cells” edited by Paolo DiNardo, River Publishers. in press (2011)
  4. Lepperdinger, G., Singh, S., Kloss, F. Reponses of MSC to varying oxygen availability in vitro and in vivo. (book chapter) in: “Stem Cell Engineering, Principles & Applications” (ed. Artmann, G.M.Hescheler, J. & Minger St.) Springer, Berlin ISBN-10: 364211864X (2010)
  5. Lepperdinger, G., Laschober, G., Brunauer, R., Greiderer, B., Reitinger, St., Fehrer, C. Are stem cells growing (you) old – why (not) hesitating to apply them in the clinics. Book chapter “Impact in Ageing: a common challenge for Europe and Asia”, edited by G. Jones, S. Linhart, K. Hirokawa, G. Sinigoj, LIT Publ Int. (2007)
  6. Lepperdinger, G. Altern Stammzellen? Jungbrunnen oder bloßesWunschdenken (Do stem cells age? Fountain of Youth or Wishful Thinking. Biologie in unserer Zeit. Invited article. Biologie in unserer Zeit 37(3)184 pp - DOI:10.1002/biuz.200610336 (2007)
  7. Lepperdinger, G. Control of hyaluronan homeostasis (book chapter) In: “Hyaluronan. Structure, Metabolism, Biological Activities, Therapeutic Applications” Edited by Endre A. Balasz and Vincent C Hascall Matrix Biology Institute NJ USA 199-204 (2005)
  8. Tontsch, S., Lepperdinger, G., Artner, I., Bauer, H. C. Automated in situ hybridization. In "Molecular Morphology in Human Tissues", G.W. Hacker & R.R. Tubbs (eds.) Book Series: Advances in Pathology, Microscopy & Molecular Morphology, CRC-Press Boca Raton, FL USA (2004)
  9. Lepperdinger, G., Kreil, G. Functional, structural and biological properties of hyaluronidases (book chapter) In: “Chemistry and Biology of Hyaluronan” Edited by Hari G. Garg Elsevier 585-598 (2004)
  10. Lepperdinger, G., Fehrer, C. Reitinger, St. Biodegradation of hyaluronan (book chapter) In: “Chemistry and Biology of Hyaluronan” Edited by Hari G. Garg Elsevier 71-82 (2004)
  11. Lepperdinger, G., Strobl, S., Müllegger J., Kreil, G. Transcriptional regulation of Hyal-2 hyaluronidase during brain development (book chapter) in: “Hyaluronan-Chemical, Biochemical and Biological Aspects” (ed. Kennedy J.F., Phillips, G.O., Williams P.A.), Volume 2, part 12, Woodhead Publishing, Cambridge, UK (2003)