The group studies molecular mechanisms of cellular senescence in human dermal fibroblasts and vascular endothelial cells. One major focus is on the role of reactive oxygen species, both from mitochondrial and non-mitochondrial sources, in senescence and aging. In addition, we are interested in the role of mitochondrial proteins as regulators of senescence and in age-associated metabolic dysregulation. We also investigate the relationship between cellular senescence and age-associated dysfunctions and diseases, such as skin aging and cardiovascular diseases. Specific topics include the role of various stress signals on cellular aging and age-associated pathologies of human tissues.