Publications since 2012

(see PubMed)

Naismith E, Pangrazzi L, Grasse M, Keller M, Miggitsch C, Weinberger B, Trieb K, Grubeck-Loebenstein B. Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow. Immun Ageing. 2019 Aug 22;16:21. doi: 10.1186/s12979-019-0161-z. eCollection 2019.

Miggitsch C, Meryk A, Naismith E, Pangrazzi L, Ejaz A, Jenewein B, Wagner S, Nägele F, Fenkart G, Trieb K, Zwerschke W, Grubeck-Loebenstein B. Human bone marrow adipocytes display distinct immune regulatory properties. EBioMedicine. 2019 Aug;46:387-398. doi: 10.1016/j.ebiom.2019.07.023. Epub 2019 Jul 18.

Philippe M, Gatterer H, Burtscher M, Weinberger B, Keller M, Grubeck-Loebenstein B, Fleckenstein J, Alack K, Krüger K. Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects. Front Physiol. 2019 Jun 4;10:684. doi: 10.3389/fphys.2019.00684. eCollection 2019.

Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein BFcμ receptor as a Costimulatory Molecule for T Cells. Cell Rep. 2019 Mar 5;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024.

Trieb K, Meryk A, Senck S, Naismith E, Grubeck-Loebenstein BImmunological and morphological analysis of heterotopic ossification differs to healthy controls. BMC Musculoskelet Disord. 2018 Sep 11;19(1):327. doi: 10.1186/s12891-018-2246-9.

Grasse M., Meryk A., Miggitsch C., Grubeck-Loebenstein B. GM-CSF improves the immune response to the diphtheria-component in a multivalent vaccine. Vaccine 2018;36(31):4672-4680. doi: 10.1016/j.vaccine.2018.06.033.

Lukas Yani S., Keller M., Melzer F.L., Weinberger B., Pangrazzi L., Sopper S., Trieb K., Lobina M., Orrù V., Fiorillo E., Cucca F., Grubeck-Loebenstein B. CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function. Front Immunol 2018;9:1201. doi: 10.3389/fimmu.2018.01201.

Doherty T.M., Connolly M.P., Del Giudice G., Flamaing J., Goronzy J.J., Grubeck-Loebenstein B., Lambert P.H., Maggi S., McElhaney J.E., Nagai H., Schaffner W., Schmidt-Ott R., Walsh E., Di Pasquale A. Vaccination programs for older adults in an era of demographic change. Eur Geriatr Med 2018;9(3):289-300. doi: 10.1007/s41999-018-0040-8.

Weinberger B., Haks M.C., de Paus R.A., Ottenhoff T.H.M., Bauer T., Grubeck-Loebenstein B. Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitits B in Older Adults. Front Immunol 2018;9:1035. doi: 10.3389/fimmu.2018.01035.

Rietman M.L., Spijkerman A.M.W., Wong A., van Steeg H., Bürkle A., Moreno-Villanueva M., Sindlinger T., Franceschi C., Grubeck-Loebenstein B., Bernhardt J., Slagboom P.E., Toussanit O., Debacq-Chainiaux F., Sikora E., Gonos E.S., Breusing N., Stuetz W., Weber D., Grune T., Basso A., Piacenza F., Malavolta M., Collino S., Jansen E.H.J.M., Verschuren W.M.M., Dollé M.E.T. Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study. Mech Ageing Dev 2018;pii: S0047-6374(18)30025-3. doi: 10.1016/j.mad.2018.04.007.

Del Giudice G., Goronzy J.J., Grubeck-Loebenstein B., Lambert P.H., Mrkvan T., Stoddard J.J., Doherty T.M. Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging. NPJ Aging Mech Dis 2017;4:1. doi: 10.1038/s41514-017-0020-0.

Giacconi R., Costarelli L., Piacenza F., Basso A., Bürkle A., Moreno-Villanueva M., Grune T., Weber D., Stuetz W., Gonos E.S., Schön C., Grubeck-Loebenstein B., Sikora E., Toussaint O., Debacq-Chainiaux F., Franceschi C., Hervonen Al, Slagboom E., Ciccarone F., Zampieri M., Caiafa P., Jansen E., Dollé M.E.T., Breusing N., Mocchegiani E., Malavolta M. Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project. J Gerontol A Biol Sci Med Sci 2018;73(6):745-753. doi: 10.1093/gerona/glx192.

Weinberger B., Keller M., Putzer C., Breitenberger D., Koller B., Fiegl S., Moreno-Villanueva M., Bernhardt J., Franceschi C., Voutetakis K., Gonos E.S., Hurme M., Sikora E., Toussaint O., Debacq-Chainiaux F., Grune T., Breusing N., Bürkle A., Grubeck-Loebenstein B. Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study. Exp Gerontol 2017;pii:S0531-5565(17)30516-8. doi: 10.1016/j.exger.2017.08.037.

Pangrazzi L., Naismith E., Meryk A., Keller M., Jenewein B., Trieb K., Grubeck-Loebenstein B. Increased IL-15 Production and Accumulation of Highly Differentiated CD8+-Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus. Front Immunol 2017;8:715. doi: 10.3389/fimmu.2017.00715. eCollection 2017.

Weinberger B., Keller M., Grubeck-Loebenstein B. Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus. Immun Ageing 2017;14:16. doi. 10.1186/s12979-017-0099-y. eCollection 2017.

Pangrazzi L., Meryk A., Naismith E., Koziel R., Lair J., Krismer M., Trieb K., Grubeck-Loebenstein B. "Inflamm-aging" influences immune cell survival factors in human bone marrow. Eur J Immunol 2017;47(3):481-492. doi: 10.1002/eji.201646570.

Stuetz W., Weber D., Dollé M.E., Jansen E., Grubeck-Loebenstein B., Fiegl S., Toussaint O., Bernhardt J., Gonos E.S., Franceschi C., Sikora E., Moreno-Villanueva M., Breusing N., Grune T., Bürkle A. Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. Nutrients 2016;8(10). pii: E614.

Grasse M., Meryk A., Schirmer M., Grubeck-Loebenstein B., Weinberger B. Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults. Immun Ageing 2016;13(1):26. doi: 10.1186/s12979-016-0081-0.

Cavinato M., Koziel R., Romani N., Weinmüllner R., Jenewein B., Hermann M., Dubrac S., Ratzinger G., Grillari J., Schmuth M., Jansen-Dürr P. UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity. J Gerntol A Biol Sci Med Sci 2016 pii: glw150. (Epub ahead of print Aug 11)

Ejaz A., Mitterberger M.C., Lu Z., Mattesich M., Zwierzina M.E., Hörl S., Kaiser A., Viertler H.P., Rostek U., Meryk A., Khalid S., Pierer G., Bast R.C.Jr., Zwerschke W. Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition. EBioMedicine 2016;6:149-161. doi: 10.1016/j.ebiom.2016.03.030.

Ciccarone F., Malavolta M., Calabrese R., Guastafierro T., Bacalini M.G., Reale A., Franceschi C., Capri, M., Hervonen A., Hurme M., Grubeck-Loebenstein B., Koller B., Bernhardt J., Schön C., Slagboom P.E., Toussaint O., Sikora E., Gonos E.S., Breusing N., Grune T., Jansen E., Dollé M., Moreno-Villanueva M., Sindlinger T., Bürkle A., Zampieri M., Caiafa P. Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Aging Cell 2016;15(4):755-765. doi: 10.1111/acel.12485.

Zlamy M., Almanzar G., Parson W., Schmidt C., Leierer J., Weinberger B., Jeller V., Unsinn K., Eyrich M., Würzner R., Prelog M. Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy. Immunity & Ageing 2016;13:3. doi: 10.1186/s12979-016-0058-z.

Klionsky D.J. et al. (more than 2000 co-authors, among them Meryk, A.) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016;12(1):1-222. doi: 10.1080/15548627.2015. 1100356.

Weinberger B., Joos C., Reed S.G., Coler R., Grubeck-Loebenstein B. The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. Biogerontology 2016;17:177-187. doi: 10.1007/s10522-015-9576-x.

Giampieri E., Remondini D., Bacalini M.G., Garagnani P., Pirazzini C., Yani S.L., Giuliani C., Menichetti G., Zironi I., Sala C., Capri M., Franceschi C., Bürkle A., Castellani G. Statistical strategies and stochastic predictive models for the MARK-AGE data. Mech Ageing Dev. 2015;151:45-53. doi: 10.1016/j.mad.2015.07.001.

Jansen E., Beekhof P., Cremers J., Weinberger B., Fiegl S., Toussaint O., Bernhard J., Gonos E., Capri M., Franceschi C., Sikora E., Moreno-Villanueva M., Breusing N., Grune T., Bürkle A., Dollé M.E.T. Quality control data of physiological and immunological biomarkers measured in serum and plasma. Mech Ageing Dev 2015;151:54-59. doi: 10.1016/j.mad.2015.06.004.

Lang P.A., Meryk A., Panyra A.A., Brenner D., Brüstle A., Xu H.C., Merches K., Lang F., Khairnar V., Sharma P., Funkner P., Recher M., Shaabani N., Duncan G.S., Duhan V., Homey B., Ohashi P.S., Häussinger D., Knolle P.A., Honke N., Mak T.W., Lang K.S. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015;22(1):164-173. doi: 10.1038/cdd.2014.138.

Leitner J., Herndler-Brandstetter D., Zlabinger G.J., Grubeck-Loebenstein B., Steinberger P. CD58/CD2 is the primary costimulatory pathway in human CD28-CD8+ T cells. J Immunol 2015;195(2):477-487. doi: 10.4049/jimmunol.1401917.

Grubeck-Loebenstein B. Immungerontologie – Alternsforschung (Immunogerontology – Research into aging). Z Rheumatol 2015;74:435-437. doi: 10.1007/s00393-014-1562-1.

Capri M., Moreno-Villanueva M., Cevenini E., Pini E., Scurti M., Borelli V., Palmas M.G., Zoli M., Schön C., Siepelmeyer A., Bernhardt J., Fiegl S., Zondag G., de Craene A.J., Hervonen A., Hurme M., Sikora E., Gonos E.S., Voutetakis K., Toussaint O., Debacq-Chainiaux F., Grubeck-Loebenstein B., Bürkle A., Franceschi C. MARKAGE population: From the human model to new insights. Mech Ageing Dev 2015;151:13-17. doi: 10.1016/j.mad.2015.03.010.

Bürkle A., Moreno-Villanueva M., Bernhard J., Blasco M., Zondag G., Hoeijmakers J.H., Toussaint O., Grubeck-Loebenstein B., Mocchegiani E., Collino S., Gonos S., Sikora E., Gradinaru D., Dolle M., Salmon M., Kristensen P., Griffiths H.R., Libert C., Grune T., Breusing N., Simm A., Franceschi C., Capri M., Talbot D., Caiafa P., Friguet B., Slagboom P.E., Hervonen A., Hurme M., Aspinall R. MARK-AGE biomarkers of ageing. Mech Ageing  Dev 2015;151:2-12. doi: 10.1016/j.mad.2015.03.006.

Schosserer M., Grubeck-Loebenstein B., Grillari J. Grundlagen der biologischen Alterung (Principles of biological aging). Z Gerontol Geriatr 2015;48(3):285-294. doi: 10.1007/s00391-015-0857-4.

Giefing-Kröll C., Berger P., Lepperdinger G., Grubeck-Loebenstein B. How sex and age affect immune responses, susceptibility to infections and response to vaccination. Aging Cell 2015;14(3):309-321. doi: 10.1111/acel.12326.

Pritz T., Lair J., Ban M., Keller M., Weinberger B., Krismer M., Grubeck-Loebenstein B. Plasma cell numbers decrease in bone marrow of old patients. Eur J Immunol 2015;45(3):738-746. DOI: 10.1002/eji.201444878

Del Giudice G., Weinberger B., Grubeck-Loebenstein B. Vaccines for the elderly. Gerontology 2015;61(3): 203-210. doi: 10.1159/000366162. 

Pritz T., Weinberger B., Grubeck-Loebenstein B. The aging bone marrow and its impact on immune responses in old age. Immunol Lett 2014;162(1 Pt B):310-315. doi: 10.1016/j.imlet.2014.06.016.

Sansoni P., Vescovini R., Fagnoni F.F., Akbar A., Arens R., Chiu Y.L., Cičin-Šain L., Dechanet-Merville J., Derhovanessian E., Ferrando-Martinez S., Franceschi C., Frasca D., Fulöp T., Furman D., Gkrania-Klotsas E., Goodrum F., Grubeck-Loebenstein B., Hurme M., Kern F., Lilleri D., López-Botet M., Maier A.B., Marandu T., Marchant A., Matheï C., Moss P., Muntasell A., Remmerswaal E.B., Riddell N.E., Rothe K., Sauce D., Shin E.C., Simanek A.M., Smithey M.J., Söderberg-Nauclér C., Solana R., Thomas P.G., van Lier R., Pawelec G., Nikolich-Zugich J. New advances in CMV and immunosenescence. Exp Gerontol 2014;55C:54-62. doi: 10.1016/j.exger.2014.03.020.

Menter T., Giefing-Kroell C., Grubeck-Loebenstein B., Tzankov A. Characterization of the Inflammatory Infiltrate in Streptococcus pneumoniae Pneumonia in Young and Elderly Patients. Pathobiology 2014;15;81(3):160-167.

Arnold C., Pritz T., Brunner S., Knabb C., Salvenmoser W., Holzwarth B., Thedieck K., Grubeck-Loebenstein B. T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28- T cells. Exp Gerontol 2014;54:75-83. doi: 10.1016/j.exger.2014.01.018.

Welzl K., Weinberger B., Kronbichler A., Sturm G., Kern G., Mayer G., Grubeck-Loebenstein B., Koppelstätter C. How immunosuppressive therapy affects T cells from kidney transplanted patients of different age: The role of latent CMV infection. Clin Exp Immunol 2014;176(1):112-119.

Welzl K., Kern G., Mayer G., Weinberger B., Säemann M.D., Sturm G., Grubeck-Loebenstein B., Koppelstätter C. Effect of different immunosuppressive drugs on immune cells from young and old healthy persons. Gerontology 2014;60(3):229-238. doi: 10.1159/000356020.

Weinberger B., Schirmer M., Matteucci Gothe R., Siebert U., Fuchs D., Grubeck-Loebenstein B. Recall Responses to Tetanus and Diphtheria Vaccination are frequently insufficient in elderly persons. PLoS One, 2013;8(12) e82967.

Pritz T., Landgraf-Rauf K., Herndler-Brandstetter D., Rauf R., Lair J., Gassner R., Weinberger B., Krismer M., Grubeck-Loebenstein B. Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system. Immun Ageing 2013;10(1):17.

Da Silva L., Godejohann M., Martin F.-P., Collino S., Bürkle A., Moreno-Villanueva M., Bernhardt J., Toussaint O., Grubeck-Loebenstein B., Gonos E.S., Sikora E., Grune T., Breusing N., Franceschi C., Hervonen A., Spraul M., Moco S. High-Resolution Quantitative Metabolome Analysis of Urine by Automated Flow Injection NMR. Anal Chem 2013;85(12):5801-5809.

Boraschi D., Aguado Teresa M., Dutel C., Goronzy J., Louis J., Grubeck-Loebenstein B., Rappuoli R., Del Giudice G. The Gracefully Aging Immune System. Science Translational Medicine 2013;185(5):185ps8.

Dejaco C., Duftner C., Al-Massad J., Wagner A.D., Park J.-K., Fessler J., Aigelsreiter A., Hafner F., Vega S., Sterlacci W., Grubeck-Loebenstein B., Tzankov A., Ness T., Boiardi L., Salvarani C., Schirmer M. NKGD2 stimulated T-cell autoreactivity in giant cell arteritis and polymyalgia rheumatica. Ann Rheum Dis 2013;72:1852-1859.

Weinberger B., Grubeck-Loebenstein B. Vaccines for the elderly. Clin Microbiol Infec, 2012;18(Suppl. 5):100-108.

Solana R., Tarazona R., Aiello A.E., Akbar A.N., Appay V., Beswick M., Bosch J.A., Campos C., Cantisán S., Cicin-Sain L., Derhovanessian E., Ferrando-Martínez S., Frasca D., Fulöp T., Govind S., Grubeck-Loebenstein B., Hill A., Hurme M., Kern F., Larbi A., López-Botet M., Maier A.B., McElhaney J.E., Moss P., Naumova E., Nikolich-Zugich J., Pera A., Rector J.L., Riddell N., Sanchez-Correa B., Sansoni P., Sauce D., van Lier R., Wang G.C., Wills M.R., Zielinski M., Pawelec G. CMV and immunosenescence: From basics to clinics. Immun Ageing 2012;9:23. doi:10.1186/1742-4933-9-23.

Grubeck-Loebenstein B. What is ageing? Transfus Med Hemoth 2012;39:299-300.

Wolf J., Weinberger B., Arnold C., Maier A.B., Westendorp R.G.J., Grubeck-Loebenstein B. The effect of chronological age on the inflammatory response of human fibroblasts. Exp Gerontol 2012;47:749-753.

Wolf J., Weinberger B., Grubeck-Loebenstein B. The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence. Immunity & Ageing 2012;9:1.

Stiasny K., Aberle J., Keller M., Grubeck-Loebenstein B., Heinz F.X. Age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis. PlOS One 2012;7(3):e34145.

Brunner S., Herndler-Brandstetter D., Arnold C.R., Wiegers J.G., Villunger A., Hackl M., Grillari J., Moreno-Villanueva M., Bürkle A., Grubeck-Loebenstein B. Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death. Aging Cell 2012;11(4):579-587.

Weinberger B., Grubeck-Loebenstein B. Vaccination in the elderly. In: “Immunosenescence” (Series: Birkhäuser Advances in Infectious Diseases). A. Thiel (ed.), Springer Basel AG 2012, pp 157-174. ISBN: 978-3-0346-0218-1.

Herndler-Brandstetter D., Landgraf K., Tzankov A., Jenewein B., Brunauer R., Laschober G.T., Parson W., Kloss F., Gassner R. Lepperdinger G., Grubeck-Loebenstein B. The impact of aging on memory T cell phenotype and function in the human bone marrow. J Leukoc Biol 2012;91:197-205.

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