Publications

Flavia Laffleur, Katharina Bachleitner, Gioconda Millotti, Jennifer Lagast, Florina Veider and Andreas Bernkop-Schnürch. The progress of hyaluronic acid’s application in therapeutic delivery. Therapeutic Delivery. doi.org/10.1080/20415990.2025.2483150

Soheil Haddadzadegan, Ahmad Saleh, Florina Veider, Patrick Knoll, Flavia Laffleur, Gergely Kali & Andreas Bernkop-Schnürch. Cyclodextrin-mediated enhancement of gastrointestinal drug delivery: unveiling mucoadhesive and mucopenetrating synergy. March 2025. Drug Delivery and Translational Research https://doi.org/10.1007/s13346-025-01832-w

Flavia Laffleur, Gioconda Millotti, Jennifer Lagast. An overview of oral bioavailability enhancement through self- emulsifying drug delivery systems. March 2025. Expert Opinion on Drug Delivery. DOI: 10.1080/17425247.2025.2479759.

Eva Sanchez Armengol, Brunella Grassiri, Anna Maria Piras, Ylenia Zambito, Angela Fabiano, Flavia Laffleur;  Ocular antibacterial chitosan-maleic acid hydrogels: In vitro and in vivo studies for a promising approach with enhanced mucoadhesion; International Journal of Biological Macromolecules 254 (2024) 127939

Veider F, Haddadzadegan S, Sanchez Armengol E, Laffleur F, Kali G, Bernkop-Schnürch A.  Inhibition of P-glycoprotein-mediated efflux by thiolated cyclodextrins. Carbohydr Polym. 2024 Mar 1;327:121648. doi: 10.1016/j.carbpol.2023.121648.

Laffleur F, Mayer AH, Oral nanoparticulate drug delivery systems for the treatment of intestinal bowel disease and colorectal cancer. Expert Opin Drug Deliv. 2023 Jul-Dec;20(11):1595-1607. doi: 10.1080/17425247.2023.2289586.

Eva Sanchez Armengol , Brunella Grassiri, Anna Maria Piras, Ylenia Zambito, Angela Fabiano , Flavia Laffleur. Endophthalmitis therapy revolution: Proof of concept based on in vivo evaluation of maleic acid modified chitosan. Journal of Drug Dev Sci and Tech. 96 (2024) 105668

Haddadzadegan S, To D, Matteo Jörgensen A, Wibel R, Laffleur F, Bernkop-Schnürch A. Comparative Analysis of PEG-Free and PEG-Based Self-Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides. Small. 2024 Feb 2:e2307618. doi: 10.1002/smll.202307618.

Sanchez Armengol E, Hock N, Saribal S, To D, Summonte S, Veider F, Kali G, Bernkop-Schnürch A, Laffleur F.  Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering. Eur J Pharm Sci. 2024 Apr 3;196:106761. doi: 10.1016/j.ejps.2024.106761.

Johannes Fiala, Thomas Roach, Andreas Holzinger, Yurii Husiev, Lisa Delueg, Fabian Hammerle, Eva Sanchez Armengol, Harald Schöbel, Sylvestre Bonnet, Flavia Laffleur, Ilse Kranner, Michaela Lackner, Bianka Siewert. The Light-activated Effect of Natural Anthraquinone Parietin against Candida auris and Other Fungal Priority Pathogens. Planta Med 2024;90:588-594

Eva Sanchez Armengol , Luis Alberto Sanchez Soler , Flavia Laffleur . Eudragit-maleimide as total denture base material: Proof of concept for a promising mucoadhesive strategy. Journal of Drug Delivery Science and Technology July 2024; 100(3):106002. DOI: 10.1016/j.jddst.2024.106002.

Worawan Tiatragoon, Flavia Laffleur, Kesinee Netsomboon. Development of curcumin-loaded lipid nanocapsules for drug delivery across mucus. Journal of Drug Delivery Science and Technology. September 2024 99(46):106014. DOI: 10.1016/j.jddst.2024.106014.

Mario Jug, Flavia Laffleur, Gioconda Millotti. Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning. September 2024. Drug Design, Development and Therapy. 18:4153-4182. DOI: 10.2147/DDDT.S473178

Kai Berkenfeld, Simone Carneiro, Carolina Corzo , Flavia Laffleur , Sharareh Salar-Behzadi, Benjamin Winkeljann, Golbarg Esfahani. Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics. October 2024. European Journal of Pharmaceutics and Biopharmaceutics. 2024:114530. DOI: 10.1016/j.ejpb.2024.114530.

Eva Sanchez Armengol, Luis Alberto Sánchez Soler, Noah Valverde Offermann, Flavia Laffleur. Polymer powerhouse: Methyl methacrylate – A breakthrough blend for superior adhesion to gingiva. Dental Materials. October 2024. 40(12). DOI: 10.1016/j.dental.2024.10.002.

Florina Veider, Dennis To, Ahmad Saleh, Flavia Laffleur, Gergely Kali, Dominik Hense, Oliver I. Strube, Andreas Bernkop-Schnürch. Charge-converting nanocarriers: Phosphorylated polysaccharide coatings for overcoming intestinal barriers. International Journal of Biological Macromolecules. Volume 281, Part 2, November 2024, 136308.

Flavia Laffleur. Mucoadhesive Chitosan in Drug Delivery. In: Advances in Polymer Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2024_180.

Katrin Zoller, Flavia Laffleur, Victor Claus, Patrick Knoll, Dennis To, Andreas Bernkop-Schnürch; Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight heparin; Journal of Drug Delivery Science and Technology; Volume 86, September 2023, 104686

Victor Claus, Helen Spleis, Christoph Federer, Katrin Zoller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse, Andreas Bernkop-Schnürch; Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine; International Journal of Pharmaceutics. Volume 639, 25 May 2023, 122964

Daniel Stengel, Betül Hilal Demirel, Patrick Knoll, Martyna Truszkowska, Flavia Laffleur, Andreas Bernkop-Schnürch; PEG vs. zwitterions: How these surface decorations determine cellular uptake of lipid-based nanocarriers; Journal of Colloid and Interface Science; Volume 647, October 2023, Pages 52-64

Gergely Kali, Bengi Özkahraman, Flavia Laffleur, Patrick Knoll, Richard Wibel, Katrin Zöller, and Andreas Bernkop-Schnürch; Thiolated Cellulose: A Dual-Acting Mucoadhesive and Permeation- Enhancing Polymer; Biomacromolecules 2023, 24, 4880−4889

Eva Sanchez Armengol, Alexander Unterweger & Flavia Laffleur; PEGylated drug delivery systems in the pharmaceutical field: past, present and future perspective; Drug Development and Industrial Pharmacy, 48:4, 129-139, DOI: 10.1080/03639045.2022.2101062

Eva Sanchez Armengol, Aletta Blanka Kerezsi, Flavia Laffleur; Allergies caused by textiles: control, research and future perspective in the medical field,; International Immunopharmacology. Volume 110, September 2022, 109043

Gergely Kali, Soheil Haddadzadegan, Flavia Laffleur, Andreas Bernkop-Schnürch; Per-thiolated cyclodextrins: Nanosized drug carriers providing a prolonged gastrointestinal residence time; Carbohydrate Polymers Volume 300, 15 January 2023, 120275

Flavia Laffleur, Nikolas Hormann, Ronald Gust, Ariane Ganner; Synthesis, characterization and evaluation of hyaluronic acid-based polymers for nasal delivery; International Journal of Pharmaceutics 631 (2023) 122496

Richard Wibel, Arne Matteo Jorgensen, Flavia Laffleur, Helen Spleis, Victor Claus, Andreas Bernkop-Schnürch; Oral delivery of calcitonin-ion pairs: In vivo proof of concept for a highly lipophilic counterion; International Journal of Pharmaceutics; Volume 631, 25 January 2023, 122476

Eva Sanchez Armengol, Patrick Knoll, Andrea Hupfauf, Ronald Gust & Flavia Laffleur;Chitosan–maleic acid conjugate as potential excipient candidate for oral drug delivery? Future Med. Chem 10.4155/fmc-2022-0258

Philipp Uhl, Max Sauter, Tobias Hertlein, Dominik Witzigmann, Flavia Laffleur, Götz Hofhaus, Veronika Fidelj, Anja Tursch, Suat Özbek, Elisa Hopke, Uwe Haberkorn, Andreas Bernkop-Schnürch, Knut Ohlsen, Gert Fricker, and Walter Mier*,Overcoming the Mucosal Barrier: Tetraether Lipid-Stabilized Liposomal Nanocarriers Decorated with Cell-Penetrating Peptides Enable Oral Delivery of Vancomycin. Adv. Therap. 2021, 2000247

Hung Thanh Lam, Oˇzbej Zupancic, Flavia Laffleur, Andreas Bernkop-Schnürch, Mucoadhesive properties of polyacrylates: Structure – Function relationship. Int. J. of Adhesion and Adhesives Volume 107, June 2021, 102857

Daniela Harrer, Eva Sanchez Armengol, Julian Friedl, Aamir Jalil, Max Jelkmann, Christina Leichner, Flavia Laffleur. Is hyaluronic acid the perfect excipient for the pharmaceutical need? Int. J. of Pharmaceutics. Volume 601, 15 May 2021, 120589

Generations of Chitosan: The Progress in Drug Delivery; May 2021. DOI:10.1007/12_2021_97; In book: Chitosan for Biomaterials IV (pp.1-22)

Flavia Laffleur, Bettina Bauer. Progress in nasal drug delivery systems. Int. J. Pharmaceutics. Volume 607 (2021) 120994

Sanchez Armengol E, Harmanci M, Laffleur F. Current strategies to determine antifungal and antimicrobial activity of natural compounds. Microbiol Res. 2021 Nov;252:126867. doi: 10.1016/j.micres.2021.126867. Epub 2021 Sep 9.

Laffleur F, Ataii M, Nagler M. Evaluation of cellulose based films comprising tea tree oil against dermatophytes and yeasts. Eur J Pharm Sci. 2021 Sep 11;167:105989. doi: 10.1016/j.ejps.2021.105989. 

Asim MH, Nazir I, Jalil A, Laffleur F, Matuszczak B, Bernkop-Schnürch A. Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs. ACS Appl Mater Interfaces. 2020 Feb 19;12(7):7942-7950. doi: 10.1021/acsami.9b21335.

Ismail R, Nhu Quynh Phan T, Laffleur F, Csoka I, Bernkop-Schnürch A. Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery. Eur J Pharm Biopharm. 2020 May 1. pii: S0939-6411(20)30112-0. doi: 10.1016/j.ejpb.2020.04.025

Jelkmann M, Leichner C, Zaichik S, Laffleur F, Bernkop-Schnürch A. A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery. Int J Biol Macromol. 2020 May 4. pii: S0141-8130(20)32977-9. doi: 10.1016/j.ijbiomac.2020.04.114.

Netsomboon K, Jalil A, Laffleur F, Hupfauf A, Gust R, Bernkop-Schnürch A.  Thiolated chitosans: Are Cys-Cys ligands key to the next generation?  Caborhydr Polym. 2020 August 15; 242; 116395

Laffleur F, Keckeis V. Advances in drug delivery systems: Work in progress still needed? Int J Pharm. 2020 Jun 12;2:100050. doi: 10.1016/j.ijpx.2020.100050

Laffleur F, Egeling M. Evaluation of cellulose based patches for oral mucosal impairment. J Drug Deliv. Sci. Technol. 2020 Jun; 58:101839

Phan, Thi Nhu Quynh & Ismail, Ruba & Le-Vinh, Bao & Zaichik, Sergey & Laffleur, Flavia & Bernkop-Schnürch, Andreas. (2020). The Effect of Counterions in Hydrophobic Ion Pairs on Oral Bioavailability of Exenatide. ACS Biomaterials Science & Engineering. XXXX. 10.1021/acsbiomaterials.0c00637.

Sanchez Armengol E, Laffleur F, The progress on sulfhydryl modified polymers with regard to synthesis, characterization and mucoadhesion. Int.J.Pharm. 2020 Nov

Jalil A, Asim MH, Le NN, Laffleur F, Matuszczak B, Tribus M, Bernkop-Schnürch A. S-protected gellan gum: Decisive approach towards mucoadhesive antimicrobial vaginal films. Int J Biol Macromol. 2019 Jun 1;130:148-157. doi: 10.1016/j.ijbiomac.2019.02.092.

Menzel C, Hauser M, Frey A, Jelkmann M, Laffleur F, Götzfried SK, Gust R, Bernkop-Schnürch A. Covalently binding mucoadhesive polymers: N-hydroxysuccinimide grafted polyacrylates. Eur J Pharm Biopharm. 2019 Jun;139:161-167. doi: 10.1016/j.ejpb.2019.02.017.

Laffleur F, Röttges S. Mucoadhesive approach for buccal application: Preactivated chitosan. European Polymer Journal, Volume 113, 2019, pp. 60-66

Laffleur F, Küppers P. Adhesive alginate for buccal delivery in aphthous stomatitis. Carbohydr Res. 2019 May 15;477:51-57. doi: 10.1016/j.carres.2019.03.009.

Laffleur F, Röttges S. Buccal adhesive chitosan conjugate comprising pilocarpine for xerostomia. Int J Biol Macromol. 2019 May 31;135:1043-1051. doi: 10.1016/j.ijbiomac.2019.05.219.

Lupo N, Tkadlečková VN, Jelkmann M, Laffleur F, Hetényi G, Kubová K, Bernkop-Schnürch A. Self-emulsifying drug delivery systems: In vivo evaluation of their potential for oral vaccination. Acta Biomater. 2019 Jun 19. pii: S1742-7061(19)30437-4. doi: 10.1016/j.actbio.2019.06.026.

Laffleur F, Strasdat S. Gelatin-based formulations for dermal application. European Polymer Journal, Volume 118, September 2019, Pages 542-550, doi.org/10.1016/j.eurpolymj.2019.06.013

Leichner C, Jelkmann M, Prüfert F, Laffleur F, Bernkop-Schnürch A. Intestinal enzyme delivery: Chitosan/tripolyphosphate nanoparticles providing a targeted release behind the mucus gel barrier. Eur J Pharm Biopharm. 2019 Nov;144:125-131. doi: 10.1016/j.ejpb.2019.09.012.

Laffleur F, Bernkop-Schnürch A. Evaluation of dermal adhesive formulations for topical application. Eur J Pharm Biopharm. 2018 Mar; 124:89-94. doi: 10.1016/j.ejpb.2017.12.010.

Laffleur F, Nasal patches containing naphazoline for management of nasal impairments. J Drug Deliv. Sci. Technol. 2018 Feb 45; 54-59. doi.org/10.1016/j.jddst.2018.02.012.

Laffleur F. Novel adhesive hyaluronic acid based solid dosage form for pediatric application. J Drug Deliv. Sci. Technol. 2018 April 44; 213-219. doi.org/10.1016/j.jddst.2017.12.012.

Laffleur F. Comparative mucoadhesive study of hyaluronic acid‐based conjugates on different mucosae. J Appl Polym Sci. 2018 April 135 (35). doi: 10.1002/app.46071.

Laffleur F. Nasal adhesive patches - Approach for topical application for dry nasal syndrome. Int J Biol Macromol. 2018 May; 111:493-497. doi: 10.1016/j.ijbiomac.2018.01.043.

Menzel C, Holzeisen T, Laffleur F, Zaichik S, Abdulkarim M, Gumbleton M, Bernkop-Schnürch A. In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide. J Control Release. 2018 May 10; 277:165-172. doi: 10.1016/j.jconrel.2018.03.018.

Jalil A, Matuszczak B, Nguyen Le NM, Mahmood A, Laffleur F, Bernkop-Schnürch A. Synthesis and Characterization of Thiolated PVP-Iodine Complexes: Key to Highly Mucoadhesive Antimicrobial Gels. Mol Pharm. 2018 Aug 6; 15(8):3527-3534. doi: 10.1021/acs.molpharmaceut.8b00503.

Laffleur F, Krouská J, Tkacz J, Pekař M, Aghai F, Netsomboon K. Buccal adhesive films with moisturizer- the next level for dry mouth syndrome? Int J Pharm. 2018 Oct 25; 550(1-2):309-315. doi: 10.1016/j.ijpharm.2018.08.032.

Laffleur F, Netsomboon K, Erman L, Partenhauser A. Evaluation of modified hyaluronic acid in terms of rheology, enzymatic degradation and mucoadhesion. Int J Biol Macromol. 2018 Nov 19; 123:1204-1210. doi: 10.1016/j.ijbiomac.2018.11.186.

Menzel C, Jelkmann M, Laffleur F, Bernkop-Schnürch A. Nasal drug delivery: Design of a novel mucoadhesive and in situ gelling polymer. Int J Pharm. 2017 Jan 30; 517(1-2):196-202. doi: 10.1016/j.ijpharm.2016.11.055.

Netsomboon K, Suchaoin W, Laffleur F, Prüfert F, Bernkop-Schnürch A. Multifunctional adhesive polymers: Preactivated thiolated chitosan-EDTA conjugates. Eur J Pharm Biopharm. 2017 Feb; 111:26-32. doi: 10.1016/j.ejpb.2016.10.029.

Laffleur F, Ataii M. Preparation and evaluation of a novel dosage form for onychomycosis. Int J Pharm. 2017 Feb 25; 518(1-2):105-110. doi: 10.1016/j.ijpharm.2016.12.055.

Partenhauser A, Netsomboon K, Pereira de Sousa I, Laffleur F, Bernkop-Schnürch A. Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties. J Biomed Mater Res B Appl Biomater. 2017 Apr; 105(3):551-559. doi: 10.1002/jbm.b.33575.

Laffleur F, Knapp K, Suchaoin W, Partenhauser A, Netsomboon K, Bernkop-Schnürch A. Comparison of mucoadhesive and cohesive features of poly(acrylic acid)-conjugates respective their molecular mass. Eur J Pharm Biopharm. 2017 Apr; 113:149-156. doi: 10.1016/j.ejpb.2016.12.022.

Mahmood A, Lanthaler M, Laffleur F, Huck CW, Bernkop-Schnürch A. Thiolated chitosan micelles: Highly mucoadhesive drug carriers. Carbohydr Polym. 2017 Jul 1; 167:250-258. doi: 10.1016/j.carbpol.2017.03.019.

Laffleur F, Michalek M. Modified xanthan gum for buccal delivery-A promising approach in treating sialorrhea. Int J Biol Macromol. 2017 Sep; 102:1250-1256. doi: 10.1016/j.ijbiomac.2017.04.123.

Laffleur F, Pschick S, Barthelmes J, Hauptstein S, Bernkop-Schnurch A. Impact of Surfactants on Skin Penetration of Dexpanthenol. Curr Drug Deliv. 2017 May 3; 15(3):351-356 doi: 10.2174/1567201814666170503142707.

Laffleur F, Netsomboon K, Bernkop-Schnürch A, Westmeier D, Stauber R.H, Docter D. Comprehensive mucoadhesive study of anionic polymers and their derivate. European Polymer Journal 2017; 93:314-322. doi: 10.1016/j.eurpolymj.2017.06.012.

Laffleur F, Bernkop-Schnürch A. Evaluation of peptide drug delivery via skin barrier-impact of permeation enhancers. J Drug Deliv. Sci. Technol. Oct 2017; 41: 191-196. doi: 10.1016/j.jddst.2017.07.007

Laffleur F, Ijaz M, Menzel C. Screening of anionic-modified polymers in terms of stability, disintegration, and swelling behavior. Drug Dev Ind Pharm. 2017 Nov;43(11):1866-1872. doi: 10.1080/03639045.2017.1349789.

Laffleur F. Evaluation of chemical modified hydrogel formulation for topical suitability. Int J Biol Macromol. 2017 Dec; 105(Pt 1):1310-1314. doi: 10.1016/j.ijbiomac.2017.07.152.

Leichner C, Menzel C, Laffleur F, Bernkop-Schnürch A. Development and in vitro characterization of a papain loaded mucolytic self-emulsifying drug delivery system (SEDDS). Int J Pharm. 2017 Sep 15; 530(1-2):346-353. doi: 10.1016/j.ijpharm.2017.08.059.

Mahmood A, Laffleur F, Leonaviciute G, Bernkop-Schnürch A. Protease-functionalized mucus penetrating microparticles: In-vivo evidence for their potential. Int J Pharm. 2017 Oct 30; 532(1):177-184.doi: 10.1016/j.ijpharm.2017.08.114.

Ijaz M, Prantl M, Lupo N, Laffleur F, Hussain Asim M, Matuszczak B, Bernkop-Schnürch A. Development of pre-activated α-cyclodextrin as a mucoadhesive excipient for intra-vesical drug delivery. Int J Pharm. 2017 Dec 20; 534(1-2):339-347. doi: 10.1016/j.ijpharm.2017.10.054.

Laffleur F, Bacher L, Netsomboon K. Design, characterization and in vitro evaluation of a novel thiolated polymer: preactivated carboxymethyl cellulose. Ther Deliv. 2016; 7(1):7-14. doi: 10.4155/tde.15.86.

Laffleur F, Messirek A. Development of mucoadhesive thio-carboxymethyl cellulose for application in buccal delivery of drugs. Ther Deliv. 2016; 7(2):63-71. doi: 10.4155/tde.15.91.

Laffleur F. Mucoadhesive therapeutic compositions: a patent review (2011-2014). Expert Opin Ther Pat. 2016; 26(3):377-88. doi: 10.1517/13543776.2016.1145209. Epub 2016 Feb 10. Review.

Deutel B, Laffleur F, Palmberger T, Saxer A, Thaler M, Bernkop-Schnürch A. In vitro characterization of insulin containing thiomeric microparticles as nasal drug delivery system. Eur J Pharm Sci. 2016 Jan 1; 81:157-61. doi: 10.1016/j.ejps.2015.10.022.

Mahmood A, Bonengel S, Laffleur F, Ijaz M, Idrees MA, Hussain S, Huck CW, Matuszczak B, Bernkop-Schnürch A. Can thiolation render a low molecular weight polymer of just 20-kDa mucoadhesive? Drug Dev Ind Pharm. 2016; 42(5):686-93. doi: 10.3109/03639045.2015.1061538.

Grießinger JA, Hauptstein S, Laffleur F, Netsomboon K, Bernkop-Schnürch A. Evaluation of the impact of multivalent metal ions on the permeation behavior of Dolutegravir sodium. Drug Dev Ind Pharm. 2016; 42(7):1118-26. doi: 10.3109/03639045.2015.1115869.

Deutel B, Laffleur F, Thaurer M, Thaler M, Bernkop-Schnürch A. Assembly and in vitro characterization of thiomeric nanoparticles. Drug Dev Ind Pharm. 2016; 42(5):730-6. doi: 10.3109/03639045.2015.1081234.

Menzel C, Bonengel S, Pereira de Sousa I, Laffleur F, Prüfert F, Bernkop-Schnürch A. Preactivated thiolated nanoparticles: A novel mucoadhesive dosage form. Int J Pharm. 2016 Jan 30; 497(1-2):123-8. doi: 10.1016/j.ijpharm.2015.11.037.

Netsomboon K, Laffleur F, Suchaoin W, Bernkop-Schnürch A. Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors. Eur J Pharm Biopharm. 2016 Mar; 100:9-14. doi: 10.1016/j.ejpb.2015.11.019.

Laffleur F, Bacher L, Vanicek S, Menzel C, Muhammad I. Next generation of buccadhesive excipient: Preactivated carboxymethyl cellulose. Int J Pharm. 2016 Mar 16; 500(1-2):120-7. doi: 10.1016/j.ijpharm.2016.01.012.

Netsomboon K, Laffleur F, Bernkop-Schnürch A. P-glycoprotein inhibitors: synthesis and in vitro evaluation of a preactivated thiomer. Drug Dev Ind Pharm. 2016; 42(4):668-75. doi: 10.3109/03639045.2015.1075025.

Suchaoin W, Pereira de Sousa I, Netsomboon K, Rohrer J, Hoffmann Abad P, Laffleur F, Matuszczak B, Bernkop-Schnürch A. Mucoadhesive polymers: Synthesis and in vitro characterization of thiolated poly(vinyl alcohol). Int J Pharm. 2016 Apr 30; 503(1-2):141-9. doi: 10.1016/j.ijpharm.2016.03.006.

Menzel C, Silbernagl J, Laffleur F, Leichner C, Jelkmann M, Huck CW, Hussain S, Bernkop-Schnürch A. 2, 2’Dithiodinicotinyl ligands: Key to more reactive thiomers. Int J Pharm. 2016 Apr 30; 503(1-2):199-206. doi: 10.1016/j.ijpharm.2016.03.010.

Ijaz M, Griessinger JA, Mahmood A, Laffleur F, Bernkop-Schnürch A. Thiolated Cyclodextrin: Development of a Mucoadhesive Vaginal Delivery System for Acyclovir. J Pharm Sci. 2016 May; 105(5):1714-20. doi: 10.1016/j.xphs.2016.03.009.

Laffleur F, Zilio M, Menzel C, Lupo N, Schmutzler M. Design, modification and in vitro evaluation of pectin's bucco-adhesiveness. Ther Deliv. 2016 Jun; 7(6):369-75. doi: 10.4155/tde-2016-0019.

Laffleur F, Michalek M, Suchaoin W, Ijaz M. Design and evaluation of buccal-adhesive system made of modified xanthan. Ther Deliv. 2016 Jul; 7(7):423-9. doi: 10.4155/tde-2016-0021.

Laffleur F, Leder N, Barthelmes J. In vitro evaluation of thio-poly acrylic acid for intraoral delivery. Drug Deliv. 2016 Jul; 23(6):2065-73. doi: 10.3109/10717544.2015.1122673.

Suchaoin W, Pereira de Sousa I, Netsomboon K, Lam HT, Laffleur F, Bernkop-Schnürch A. Development and in vitro evaluation of zeta potential changing self-emulsifying drug delivery systems for enhanced mucus permeation. Int J Pharm. 2016 Aug 20; 510(1):255-62. doi: 10.1016/j.ijpharm.2016.06.045.

Ijaz M, Ahmad M, Akhtar N, Laffleur F, Bernkop-Schnürch A. Thiolated α-Cyclodextrin: The Invisible Choice to Prolong Ocular Drug Residence Time. J Pharm Sci. 2016 Sep; 105(9):2848-54. doi: 10.1016/j.xphs.2016.04.021.

Laffleur F, Zilio M, Shuwisitkul D. Modified biomolecule as potential vehicle for buccal delivery of doxepin. Ther Deliv. 2016 Oct; 7(10):683-689. doiI: 10.4155/tde-2016-0046.

Netsomboon K, Partenhauser A, Rohrer J, Elli Sündermann N, Prüfert F, Suchaoin W, Laffleur F, Bernkop-Schnürch A. Preactivated thiomers for intranasal delivery of apomorphine: In vitro and in vivo evaluation. Eur J Pharm Biopharm. 2016 Dec; 109:35-42. doi: 10.1016/j.ejpb.2016.09.004.

Zupančič O, Grieβinger JA, Rohrer J, Pereira de Sousa I, Danninger L, Partenhauser A, Sündermann NE, Laffleur F, Bernkop-Schnürch A. Development, in vitro and in vivo evaluation of a self-emulsifying drug delivery system (SEDDS) for oral enoxaparin administration. Eur J Pharm Biopharm. 2016 Dec; 109:113-121. doi: 10.1016/j.ejpb.2016.09.013.

Laffleur F, Schmelzle F, Ganner A, Vanicek S. In Vitro and Ex Vivo Evaluation of Novel Curcumin-Loaded Excipient for Buccal Delivery. AAPS PharmSciTech. 2016 Dec 27. doi: 10.1208/s12249-016-0676-y.

Laffleur F, Dachs S. Development of novel mucoadhesive hyaluronic acid derivate as lubricant for the treatment of dry eye syndrome. Ther Deliv. 2015; 6(10):1211-9. doi: 10.4155/tde.15.55.

Laffleur F, Wagner J, Mahmood A. In vitro and ex vivo evaluation of biomaterials' distinctive properties as a result of thiolation. Future Med Chem. 2015; 7(4):449-57. doi: 10.4155/fmc.14.170.

Laffleur F, Wagner J, Barthelmes J. A potential tailor-made hyaluronic acid buccal delivery system comprising rotigotine for Parkinson's disease? Future Med Chem. 2015; 7(10):1225-32. doi: 10.4155/fmc.15.66.

Nowak J, Laffleur F, Bernkop-Schnürch A. Preactivated hyaluronic acid: A potential mucoadhesive polymer for vaginal delivery. Int J Pharm. 2015 Jan 15; 478(1):383-9. doi: 10.1016/j.ijpharm.2014.11.048.

Partenhauser A, Laffleur F, Rohrer J, Bernkop-Schnürch A. Thiolated silicone oil: synthesis, gelling and mucoadhesive properties. Acta Biomater. 2015 Apr; 16:169-77. doi: 10.1016/j.actbio.2015.01.020. Epub 2015 Feb 4. Erratum in: Acta Biomater. 2015 Sep; 23:366. doi: 10.1016/j.actbio.2015.01.020.

Laffleur F, Psenner J, Suchaoin W. Permeation enhancement via thiolation: in vitro and ex vivo evaluation of hyaluronic acid-cysteine ethyl ester. J Pharm Sci. 2015 Jul; 104(7):2153-60. doi: 10.1002/jps.24456.

Laffleur F, Fischer A, Schmutzler M, Hintzen F, Bernkop-Schnürch A. Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome. Acta Biomater. 2015 Jul; 21:123-31. doi: 10.1016/j.actbio.2015.04.016.

Palmberger TF, Laffleur F, Greindl M, Bernkop-Schnürch A. In vivo evaluation of anionic thiolated polymers as oral delivery systems for efflux pump inhibition. Int J Pharm. 2015 Aug 1; 491(1-2):318-22. doi: 10.1016/j.ijpharm.2015.06.023.

Grabovac V, Laffleur F, Bernkop-Schnürch A. Thiomers: Influence of molecular mass and thiol group content of poly (acrylic acid) on efflux pump inhibition. Int J Pharm. 2015 Sep 30; 493(1-2):374-9. doi: 10.1016/j.ijpharm.2015.05.079.

Rohrer J, Zupančič O, Suchaoin W, Netsomboon K, Laffleur F, Oh S, Bernkop-Schnürch A. Synthesis and in vitro characterisation of preactivated thiolated gelatin. Original Research Article European Polymer Journal, Volume 73, December 2015, Pages 268-277. doi: 10.1016/j.eurpolymj.2015.10.023.

Mahmood A, Bonengel S, Laffleur F, Ijaz M, Leonaviciute G, Bernkop-Schnürch A. An in-vitro exploration of permeation enhancement by novel polysulfonate thiomers. Int J Pharm. 2015 Dec 30; 496(2):304-13. doi: 10.1016/j.ijpharm.2015.10.013.

Laffleur F, Hintzen F, Shahnaz G, Rahmat D, Leithner K, Bernkop-Schnürch A. Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus. Nanomedicine (Lond). 2014 Mar; 9(3):387-96. doi: 10.2217/nnm.13.26.

Laffleur F. Mucoadhesive polymers for buccal drug delivery. Drug Dev Ind Pharm. 2014 May; 40(5):591-8. doi: 10.3109/03639045.2014.892959.

Hintzen F, Laffleur F, Sarti C, Müller C, Bernkop-Schnürch A. In vitro and ex vivo evaluation of an intestinal permeation enhancing self-microemulsifying drug delivery system (SMEDDS). J Drug Deliv. Sci. Technol.Dec 2013; 23 (3): 261-267. doi: 10.1016/S1773-2247(13)50039-6.

Laffleur F, Röggla J, Idrees MA, Griessinger J. Chemical modification of hyaluronic acid for intraoral application. J Pharm Sci. 2014 Aug; 103(8):2414-23. doi: 10.1002/jps.24060.

Hintzen F, Perera G, Hauptstein S, Müller C, Laffleur F, Bernkop-Schnürch A. In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. Int J Pharm. 2014 Sep 10; 472(1-2):20-6. doi: 10.1016/j.ijpharm.2014.05.047.

Laffleur F. Thiomers, mucoadhesion and oral delivery of biomacromolecules. Curr Drug Ther. 2014; 9,56-62. doi: 10.2174/1574885509666140805004423.

Millotti G, Laffleur F, Perera G, Vigl C, Pickl K, Sinner F, Bernkop-Schnürch A. In vivo evaluation of thiolated chitosan tablets for oral insulin delivery. J Pharm Sci. 2014 Oct; 103(10):3165-70. doi: 10.1002/jps.24102.

Laffleur F, Shahnaz G, Islambulchilar Z, Bernkop-Schnürch A. Design and in vitro evaluation of a novel polymeric excipient for buccal applications. Future Med Chem. 2013 Apr; 5(5):511-22. doi: 10.4155/fmc.13.33.

Sarti F, Müller C, Iqbal J, Perera G, Laffleur F, Bernkop-Schnürch A. Development and in vivo evaluation of an oral vitamin B12 delivery system. Eur J Pharm Biopharm. 2013 May; 84(1):132-7. doi: 10.1016/j.ejpb.2012.11.024.

Rahmat D, Müller C, Shahnaz G, Leithner K, Laffleur F, Khan MI, Martien R, Bernkop Schnürch A. HEC-cysteamine particles: influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties. Drug Dev Ind Pharm. 2013 Sep; 39(9):1338-45. doi: 10.3109/03639045.2012.711834.

Laffleur F, Hintzen F, Rahmat D, Shahnaz G, Millotti G, Bernkop-Schnürch A. Enzymatic degradation of thiolated chitosan. Drug Dev Ind Pharm. 2013 Oct; 39(10):1531-9. doi: 10.3109/03639045.2012.719901.

Shahnaz G, Kremser C, Reinisch A, Vetter A, Laffleur F, Rahmat D, Iqbal J, Dünnhaupt S, Salvenmoser W, Tessadri R, Griesser U, Bernkop-Schnürch A. Efficient MRI labeling of endothelial progenitor cells: design of thiolated surface stabilized superparamagnetic iron oxide nanoparticles. Eur J Pharm Biopharm. 2013 Nov; 85(3 Pt a):346-55. doi: 10.1016/j.ejpb.2013.02.010.

Hauptstein S, Müller C, Dünnhaupt S, Laffleur F, Bernkop-Schnürch A. Preactivated thiomers: evaluation of gastroretentive minitablets. Int J Pharm. 2013 Nov 18; 456(2):473-9. doi: 10.1016/j.ijpharm.2013.08.032.

Laffleur F, Bernkop-Schnürch A. Strategies for improving mucosal drug delivery. Nanomedicine (Lond). 2013 Dec; 8(12):2061-75. doi: 10.2217/nnm.13.178. Review.

Rahmat D, Sakloetsakun D, Shahnaz G, Sarti F, Laffleur F, Schnürch AB.HEC-cysteamine conjugates: influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties.Int J Pharm. 2012 Jan 17;422(1-2):40-6. doi: 10.1016/j.ijpharm.2011.10.024.

Shahnaz G, Iqbal J, Rahmat D, Perera G, Laffleur F, Rossi D, Bernkop-Schnürch A. Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half-life. J Control Release. 2012 Feb 10; 157(3):375-82. doi: 10.1016/j.jconrel.2011.09.092.

Shahnaz G, Vetter A, Barthelmes J, Rahmat D, Laffleur F, Iqbal J, Perera G, Schlocker W, Dünnhaput S, Augustijns P, Bernkop-Schnürch A. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. Int J Pharm. 2012 May 30; 428(1-2):164-70. doi: 10.1016/j.ijpharm.2012.02.044.

Hintzen F, Laffleur F, Sarti F, Shahnaz G, Bernkop-Schnürch A. Thiomers: influence of molar mass on in situ gelling properties. Int J Pharm. 2012 Oct 15; 436(1-2):120-6. doi: 10.1016/j.ijpharm.2012.05.073.

Laffleur F, Bernkop-Schnürch A. Thiomers: promising platform for macromolecular drug delivery. Future Med Chem. 2012 Nov; 4(17):2205-16. doi: 10.4155/fmc.12.165. Review.

Hintzen F, Laffleur F, Sakloetsakun D, Leithner K, Bernkop-Schnürch A. In situ gelling properties of anionic thiomers. Drug Dev Ind Pharm. 2012 Dec; 38(12):1479-85. doi: 10.3109/03639045.2011.653813.