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 Isodiametra pulchra |
Kuales Georg
PostDoc
Current Research:
Stem cells and germ cells are able to produce every cell type of a specific organism by differentiation processes. I am interested in the genes that drive stem cell differentiation and self renewal as well as germ cell development. What is these genes’ duty in animal lineages that arose early during evolution? Are there differences to species that evolved later? To tackle those questions I am studying organisms of different clades and evolutionary levels like Macrostomum lignano (Platyhelminthes), Isodiametra pulchra (Acoela), Hydra vugaris (Cnidaria) and the fruitfly Drosophila melanogaster. A main project is to decipher the evolution, function and significance of the highly conserved meiotic regulator boule in the animal kingdom. For most male organisms defects in this particular gene mean to lose fertility.
For details on my current research see: Stem Cell
Macrostomum lignano
Curriculum vitae
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November 2010 |
PostDoc in the stem cell group of Dr. Peter Ladurner |
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August 2010 |
PhD in Natural Sciences: Zoology |
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April 2006 |
Master of Biology |
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February 2005 |
Bachelor of Biology |
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October 2001 |
Diploma programme Biology |
Publications 2011
Contributions to Scientific Books and Journals
Journal Articles (Original Papers)
- Kuales, G.; De Mulder, K.; Glashauser, J.; Salvenmoser, W.; Takashima, S.; Hartenstein, V.; Berezikov, E.; Salzburger, W.; Ladurner, P. (2011): Boule-like genes regulate male and female gametogenesis in the flatworm Macrostomum lignano.
In: DEVELOPMENTAL BIOLOGY 357/1, pp. 117 - 132. (Weblink) (DOI)
Publications 2010
Contributions to Scientific Books and Journals
Journal Articles (Original Papers)
- De Mulder, K.; Kuales, G.; Pfister, D.; Egger, B.; Seppi, T.; Eichberger, P.; Borgonie, G.; Ladurner, P. (2010): Potential of Macrostomum lignano to recover from γ-ray irradiation.
In: CELL AND TISSUE RESEARCH 339, pp. 527 - 542. (Weblink)
Publications 2009
Contributions to Scientific Books and Journals
Journal Articles (Original Papers)
- De Mulder, K.; Kuales, G.; Pfister, D.; Willems, M.; Egger, B.; Salvenmoser, W.; Thaler, M.; Gorny, A.; Hrouda, M.; Borgonie, G.; Ladurner, P. (2009): Characterization of the stem cell system of the acoel Isodiametra pulchra.
In: BMC DEVELOPMENTAL BIOLOGY 9, p. 69. - De Mulder, K.; Pfister, D.; Kuales, G.; Egger, B.; Salvenmoser, W.; Willems, M.; Steger, J.; Fauster, K.; Micura, R.; Borgonie, G.; Ladurner, P. (2009): Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms.
In: DEVELOPMENTAL BIOLOGY 334, pp. 198 - 212. - Egger, B.; Steinke, D.; Tarui, H.; De Mulder, K.; Arendt, D.; Borgonie, G.; Funayama, N.; Gschwentner, R.; Hartenstein, V.; Hobmayer, B.; Hooge, M.; Hrouda, M.; Ishida, S.; Kobayashi, C.; Kuales, G.; Nishimura, O; Pfister, D.; Rieger, R.; Salvenmoser, W.; Smith III, J.; Technau, U.; Tyler, S.; Agata, K.; Salzburger, W.; Ladurner, P. (2009): To be or not to be a flatworm: The acoel controversy.
In: PLoS One 4/5, p. 5502.
Proceedings Articles (Abstracts)
- De Mulder, K.; Moreno, E.; Egger, B.; Kuales, G.; Pfister, D.; Salvenmoser, W.; Martinez, P.; Borgonie, G.; Ladurner, P. (2009): Acoels share a stem cell system with rhabditophoran flatworms.
In: 11th International Symposium on Flatworm Biology, 26 - 30 July 2009, Diepenbeek, Belgium. Eigenverlag. - De Mulder, K.; Pfister, D.; Kuales, G.; Egger, B.; Seppi, T.; Eichberger, P.; Borgonie, G.; Ladurner, P. (2009): The potential of Macrostomum lignano to recover from gamma-ray irradiation.
In: LIFE SCIENCE Meeting. Innsbruck Universities. Igls, Tyrol. September 18 - 19, 2009. Innsbruck: Leopold-Franzens-Universität Innsbruck, p. 32. - Salvenmoser, W.; Heiss, H.; Pfister, D.; De Mulder, K.; Kuales, G.; Ladurner, P. (2009): The gonads of Macrostomum lignano and their development.
In: 11th International Symposium on Flatworm Biology, 26 - 30 July 2009, Diepenbeek, Belgium. Eigenverlag.
Publications 2008
Contributions to Scientific Books and Journals
Contributions to Textbooks, Scientific
- Ladurner, P.; Egger, B.; De Mulder, K.; Pfister, D.; Kuales, G.; Salvenmoser, W.; Schärer, L. (2008): The stem cell system of the basal flatworm Macrostomum lignano.
In: Bosch, Thomas C. (Hrsg.): Stem cells: from Hydra to man. Dordrecht, Heidelberg, London, New York, Berlin: Springer, ISBN 978-1-402-08273-3, pp. 75 - 94.
Journal Articles (Original Papers)
- Pfister, D; De Mulder, K; Hartenstein, V; Kuales, G; Borgonie, G; Marx, F; Morris, J; Ladurner, P. (2008): Flatworm stem cells and the germ line: developmental and evolutionary implications of macvasa expression in Macrostomum lignano.
In: DEVELOPMENTAL BIOLOGY 319/1, pp. 146 - 159.
Journal Articles (Meeting-Abstracts)
- Pfister, D.; De Mulder, K.; Kuales, G.; Sekii, K.; Ladurner, P. (2008): RNAi based analysis of flatworm stem cell and the germ line genes.
In: DEVELOPMENTAL BIOLOGY 319/2, p. 560.
Proceedings Articles (Abstracts)
- Egger, B.; Salzburger, W.; De Mulder, K.; Pfister, D.; Kuales, G.; Ladurner, P. (2008): Acoels are flatworms after all - stem cells as an apomorphy.
In: 2nd Meeting of the European Society for Evolutionary Developmental Biology. Eigenverlag. - Pfister, D.; De Mulder, K.; Kuales, G.; Sekii, K.; Senn, C.; Ladurner, P. (2008): Functional study of flatworm stem cells by RNA interference.
In: Joint meeting of the British (BSDB) and Spanish (SEBD) developmental biology societies, Seville, 24th-27th September 2008. Eigenverlag.
Publications 2007
Contributions to Scientific Books and Journals
Journal Articles (Original Papers)
- Pfister, D.; De Mulder, K.; Philipp, I.; Kuales, G.; Hrouda, M.; Eichberger, P.; Borgonie, G.; Hartenstein, V.; Ladurner, P. (2007): The exceptional stem cell system of Macrostomum lignano: Screening for gene expression and studying cell proliferation by hydroxyurea treatment and irradiation.
In: Frontiers in Zoology 9, pp. 4 - 9.
Proceedings Articles (Abstracts)
- De Mulder, K.; Pfister, D.; Kuales, G.; Borgonie, G.; Ladurner, P. (2007): Functional approach of piwi-like genes in basal flatworms.
In: Proceedings of the 1st International Macrostomum Meeting, Basel. Eigenverlag. - De Mulder, K.; Pfister, D.; Kuales, G.; Sekii, K.; Borgonie, G.; Ladurner, P. (2007): Piwi regulates totipotent stem cells in flatworms.
In: Book of Abstracts - 4th Annual CMBI Meeting, Igls/Tirol, September 28.09.2007 - 29.09.2007. Innsbruck: Eigenverlag. - Kuales, G.; De Mulder, K.; Pfister, D.; Ladurner, P. (2007): Boule-like gene expression during development and regeneration in basal flatworms.
In: 17. wissenschaftlichen Tagung der Gesellschaft für Entwicklungsbiologie (GfE). Book of Abstracts. Eigenverlag. - Kuales, G.; De Mulder, K.; Pfister, D.; Sekii, K.; Ladurner, P. (2007): Evolutionary twist of meiotic mechanisms: The key meiotic regulator BOULE in flatworms.
In: Proceedings of the 1st International Macrostomum Meeting, Basel. Eigenverlag.
Publications 2005
Contributions to Scientific Books and Journals
Proceedings Articles (Abstracts)
- Ladurner, P.; Pfister, D.; Kuales, G.; Gschwentner, R.; Nimeth, K.; Egger, B.; Adamski, Z.; Salvenmoser, W.; Rieger, R. (2005): Characterization of the totipotent stem cell system of the flatworm Macrostomum lignano.
In: Pulfer, K. et. al. (Eds.): Proceedings of the Microscopy Conference 2005, Davos, Switzerland, 28. August - 2. September. Villigen: Paul Scherrer Institut (= PSI Proceedings, 05-01), p. 194. - Nimeth, K.; Egger, B.; Gschwentner, R.; Salvenmoser, W.; Hrouda, M.; Rostek, U.; Gleirscher, M.; Pfister, D.; Kuales, G.; Ladurner, P.; Rieger, R. (2005): Regeneration and cellular dynamics in the basal bilaterian Macrostomum lignano.
In: Pulfer, K. et. al. (Eds.): Proceedings of the Microscopy Conference 2005, Davos, Switzerland, 28. August - 2. September. Villigen: Paul Scherrer Institut (= PSI Proceedings, 05-01), p. 196.