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Institutsvorstand, Fakultätsstudienleiter
Institut für Pharmazie / Pharmakognosie Centrum für Chemie und Biomedizin Leopold-Franzens-Universität Innsbruck Innrain 80-82 4. OG, Zi. Nr. L.04.012 A-6020 Innsbruck, Austria Tel: +43 512 507 58400 / 58499 (fax) Email: Hermann.Stuppner@uibk.ac.at
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| Forschung Research |
Publikationen Publications |
Curriculum vitae CV |
Forschung
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Isolierung und Strukturaufklärung von Sekundärstoffen aus höheren Pflanzen mit potentieller pharmakologischer Aktivität. Im Mittelpunkt des Interesses stehen Naturstoffe mit entzündungshemmender, antitumoraler und antibakterieller Aktivität (FWF-Projekt P14389)
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Nutzung sekundärer Pflanzenstoffe (Sesquiterpenlactone, Flavonoide und phenolische Carbonsäuren) als chemische Marker für die Beantwortung von Fragen der Taxonomie und Systematik innerhalb der Familie der Asteraceae und Apiaceae (FWF-Projekt P15594).
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Analytik und Qualitätsbeurteilung von (Arznei-)pflanzen mit Hilfe der GC, HPLC, CE (CZE, CEC, MEKC) und entsprechender Kopplungstechniken (GC/MS, HPLC/MS und CE/MS).
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Suche nach pflanzlichen Wirkstoffen mit Hilfe von Pharmakophormodelling und „in Silico Screening“.
Research
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Isolation and structure elucidation of secondary metabolites from higher plants with anti-inflammatory, cytotoxic and antibacterial activities (FWF-Projekt P14389)
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Secondary plant metabolites (sesquiterpene lactones, flavonoids and phenolic acids) as chemical markers for taxonomic and systematic studies of taxa within the Asteraceae and Apiaceae families (FWF-Projekt P15594).
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Analysis and quality assessment of (medicinal) plants by means of GC, HPLC, CE (CZE, CEC, MEKC) and appropriate coupling techniques (GC/MS, HPLC/MS and CE/MS).
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Search for bioactive compounds using pharmakophor modelling and „in silico screening“.
Publikationen / Publication list
Original Papers (2005 – 2012)
Noha, S.M., Jazzar, B., Kühnl, S., Rollinger, J.M., Stuppner, H., Schaible, A.M., Werz, O., Wolber, G., Schuster, D. (2012): Pharmacophore-based discovery of a novel cytosolic phospholipase A2α inhibitor. Bioorganic & Medicianl Chemistry Letters 22(2), 1202 – 1207.
Pieri, V., Sturm, S., Seger, C., Franz, C., Stuppner, H. (2012): 1H NMR-based metabolic profiling and target analysis: a combined approach for the quality control of Thymus vulgaris.Metabolomics 8(2), 335 - 346.
Remias, D., Schwaiger, S., Aigner, S., Leya, T., Stuppner, H., Lütz, C. (2012): Characterization of an UV- and VIS-absorbing, purpurogallin-derived secondary pigment new to algae and highly abundant in Mesotaenium berggrenii (Zygnematophyceae, Chlorophyta), an extremophyte living on glaciers. FEMS Microbiology Ecology 79(3), 638 - 648.
Steinmann, D., Baumgartner, R.R., Heiss, E.H., Bartenstein, S., Atanasov, A.G., Dirsch, V.M., Ganzera, M., Stuppner, H. (2012): Bioguided Isolation of (9Z)-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors. Planta Medica 78(3), 219 - 224.
Aberham, A., Pieri, V., Croom, Jr. E.M., Ellmerer, E., Stuppner, H. (2011): Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC–MS and RP-HPLC. Journal of Pharmaceutical and Biomedical Analysis 54(3), 517 – 525.
Baumgartner, L., Schwaiger, S., Stuppner, H. (2011): Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC–PDA and HPLC–MS. Journal of Pharmaceutical and Biomedical Analysis 56(3), 546 - 552.
Baumgartner, L., Sosa, S., Atanasov, A.G., Bodensieck, A., Fakhrudin, N., Bauer, J., Del Favero, G., Ponti, C., Heiss, E.H., Schwaiger, S., Ladurner, A., Widowitz, U., Della Loggia, R., Rollinger, J.M., Werz, O., Bauer, R., Dirsch, V.M., Tubaro, A., Stuppner, H. (2011): Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro. Journal of Natural Products 74(8), 1779 – 1786.
Cicek, S.S., Aberham, A., Ganzera, M., Stuppner, H. (2011): Quantitative analysis of cycolartane glycosides in black cohosh rhizomes and dietary supplements by RRLC-ELSD and RRLC-qTOF-MS. Analytical and Bioanalytical Chemistry, 400(8), 2597 - 2605.
Duwensee, K., Schwaiger, S., Tancevksi, I., Eller, K., Van Eck, M., Makrt, P., Linder, T., Stanzl, U., Ritsch, A., Patsch, J.R., Schuster, D., Stuppner, H., Bernhard, D., Eller, P. (2011): Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Atherosclerosis 219/1, 109 - 115.
Grienke, U., Mihaly-Bison, J., Schuster, D., Afonyushkin, T., Binder, M., Guan, S-H., Cheng, C-R., Wolber, G., Stuppner, H., Guo, D-A., Bochkov, V.N., Rollinger, J.M. (2011): Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum. Bioorganic & Medicinal Chemistry 19/22, 6779 - 6791.
Hornick, A., Lieb, A., Vo, N.P., Rollinger, J.M., Stuppner, H., Prast, H. (2011): The coumarin scopoletin potentiates acetylcholine release from synatposomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory. Neuroscience 197, 280 - 292
Noha, S.M., Atanasov, A.G., Schuster, D., Markt, P., Fakhrudin, N., Heiss, E.H., Schrammel, O., Rollinger, J.M., Stuppner, H., Dirsch, V.M., Wolber, G. (2011): Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques. Bioorganic and Medicinal Chemistry Letters 21(1), 577 – 583.
Pfisterer, P. H., Shen, C., Nikolovska-Coleska, Z., Schyschka, L., Schuster, D., Rudy, A., Wolber, G., Vollmar, A. M., Rollinger, J. M., Stuppner, H. (2011): In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Bioorganic & Medicinal Chemistry 19(2), 1002 – 1009.
Pieri, V., Belancic, A., Morales, S., Stuppner, H. (2011): Identification and Quantification of Major Steviol Glycosides in Stevia rebaudiana Purified Extracts by 1H NMR Spectroscopy. Journal of Agricultural and Food Chemistry 59(9), 4378 – 4384.
Safer, S., Tremetsberger, K., Guo, Y.-P., Kohl, G., Samuel, M.R., Stuessy, T.F., Stuppner, H. (2011): Phylogenetic relationships in the genus Leontopodium (Asteraceae: Gnaphalieae) based on AFLP data. Botanical Journal of The Linnean Society 165(4), 364 – 377.
Safer, S., Cicek, S.S., Pieri, V., Schwaiger, S., Schneider, P., Wissemann, V., Stuppner, H. (2011): Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of 1H NMR and HPLC-ESI-MS. Phytochemistry 72(11-12), 1379 – 1389.
Schusterr, D., Markt, P., Grienke, U., Mihaly-Bison, J., Binder, M., Noha, S.M., Rollinger, J.M., Stuppner, H., Bochkov, V.N., Wolber, G. (2011): Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.
Bioorganic & Medicinal Chemistry 19/23, 7168 - 7180.
Schwaiger, S., Zeller, I., Poelzelbauer, P., Frotschnig, S., Laufer, G., Messner, B., Pieri, V., Stuppner, H., Bernhard, D. (2011): Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). Journal of Ethnopharmacology 133(2), 704 - 709.
Waltenberger, B., Rollinger, J.M., Griesser, U., Stuppner, H., Gelbrich, T. (2011): Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba.
Acta Crystallographica. Section C: Crystal Structure Communications 67/10, 409 - 412.
Waltenberger, B., Schuster, D., Paramapjon, S., Gritsanapan, W., Wolber, G., Rollinger, J.M., Stuppner, H. (2011): Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine 18(2-3), 119 – 133.
Waltenberger, B., Wiechmann, K., Bauer, J., Markt, P., Noha, S.M., Wolber, G., Rollinger, J. M., Werz, O., Schuster, D., Stuppner, H. (2011): Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1). J. Med. Chem. 54(9), 3163 – 3174.
Aberham, A., Cicek, S.S., Schneider, P., Stuppner, H. (2010): Analysis of Sesquiterpene Lactones, Lignans, and Flavonoids in Wormwood (Artemisia absinthium L.) Using High-Performance Liquid Chromatography (HPLC)-Mass Spectrometry, Reversed Phase HPLC, and HPLC-Solid Phase Extraction-Nuclear Magnetic Resonance. Journal of Agricultural and Food Chemistry 58(20), 10817 – 10823.
Antal, D.S., Schwaiger, S., Ellmerer-Müller, E.P., Stuppner, H. (2010): Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents. Planta Medica 76(15), 1765 - 1772.
Baumgartner, R.R., Steinmann, D., Heiss, E.H., Atanasov, A.G., Ganzera, M., Stuppner, H., Dirsch, V.M. (2010): Bioactivity-Guided Isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora Roots As a PTP1B Inhibitor. Journal of Natural Products 73(9), 1578 – 1581.
Cicek, S.S., Khom, S., Taferner, B., Hering, S., Stuppner, H. (2010): Bioactivity-Guided Isolation of GABAA Receptor Modulating Constituents from the Rhizomes of Actaea racemosa. Journal of Natural Products 73(12), 2024 – 2028.
Cicek, S.S., Schwaiger, S., Ellmerer, E.P., Stuppner, H. (2010): Development of a fast and convenient method for the isolation of triterpene saponins from Actaea racemosa by high-speed countercurrent chromatography coupled with evaporative light scattering detection. Planta Medica 76(5), 467 – 473.
Fakhrudin, N., Ladurner, A., Atanasov, A.G., Heiss, E.H., Baumgartner, L., Markt, P., Schuster, D., Ellmerer, E.P., Wolber, G., Rollinger, J.M., Stuppner, H., Dirsch, V.M. (2010): Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor. Molecular Pharmacology 77(4), 559 – 566.
Gao, H., Zehl, M., Kählig, HP., Schneider, P., Stuppner, H., Banuls, L.M.Y., Kiss, R., Kopp, B. (2010): Rapid Structural Identification of Cytotoxic Bufadienolide Sulfates in Toad Venom from Bufo melanostictus by LC-DAD-MSn and LC-SPE-NMR. Journal of Natural Products 73(4), 603 – 608.
Grienke, U., Schmidtke, M., Kirchmair, J., Pfarr, K., Wutzler, P., Dürrwald, R., Wolber, G., Liedl, K.R., Stuppner, H., Rollinger, J.M. (2010): Antiviral Potential and Molecular Insight into Neuraminidase Inhibiting Diarylheptanoids from Alpinia katsumadai. Journal of Medicinal Chemistry 53(2), 778 - 786.
Pfisterer, P.H., Wolber, G., Efferth, T., Rollinger, J. M., Stuppner, H. (2010): Natural products in structure-assisted design of molecular cancer therapeutics. Current Pharmaceutical Design 16(15), 1718-1741
Pfisterer, P.H., Rollinger, J.M., Schyscka, L., Rudy, A., Vollmar, A.M., Stuppner, H. (2010): Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. Planta Medica 76(15), 1698 – 1700.
Rollinger, J.M., Kratschmar, D.V., Schuster, D., Pfisterer, P.H., Gumy, C., Aubry, E.M., Brandstötter S., Stuppner, H., Wolber, G., Odermatt, A. (2010): 11β-hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorganic & Medicinal Chemistry 18(4), 1507 - 1515.
Schuster, D., Kern, L., Hristozov, D.P., Terfloth, L., Bienfait, B., Laggner, C., Kirchmair, J., Grienke, U., Wolber, G., Langer, T., Stuppner, H., Gasteiger, J., Rollinger, J.M. (2010): Applications of integrated data mining methods to exploring natural product space for acetylcholinesterase inhibitors. Combinatorial Chemistry & High Throughput Screening 13(1), 54 – 66.
Schuster, D., Spetea, M., Music, M., Rief, S., Fink, M., Kirchmair, J., Schütz, J., Wolber, G., Langer, T., Stuppner, H., Schmidhammer, H., Rollinger, J.M. (2010): Morphinans and isoquinolines: Acetylcholinersterase inhibition, pharmacophore modeling, and interaction with opioid receptors. Bioorganic & Medicinal Chemistry 18(14), 5071 – 5080.
Schuster, D., Waltenberger, B., Kirchmair, J., Distinto, S., Markt, P., Stuppner, H., Rollinger, J.M., Wolber, G. (2010): Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part I: model generation, validation and applicability in ethnopharmacology. Molecular Informatics 29(1-2), 75 – 86.
Schwaiger, S., Hehenberger, S., Ellmerer, E.P., Stuppner, H. (2010): A new Bisabolane Derivative of Leontopodium andersonii. Natural Product Communications 5(5), 667 – 668.
Svejda, B., Aguiriano-Moser, V., Sturm, S., Hoger, H., Ingolic, E., Siegl, V., Stuppner, H., Pfragner, R. (2010): Anticancer activity of novel plant extracts from Trailliaedoxa gracilis (W. W. Smith & Forrest) in human carcinoid KRJ-I Cells. Anticancer Research 30(1), 55 – 64.
Assimopoulou A.N., Sturm, S., Stuppner, H., Papageorgiou, V.P. (2009): Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography. Biomedical Chromatography 23(2), 182 – 198.
Costa, S., Schwaiger, S., Cervellati, R., Stuppner, H., Speroni, E., Guerra, C. M. (2009): In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. Journal of Applied Toxicology 29(1), 7 – 14.
Ganzera, M., Nischang, I., Siegl, C., Senzenberger, B., Svec, F., Stuppner, H. (2009): Application of MEKC and monolithic CEC for the analysis of bioactive naphthoquinones in Eleutherine americana. Electrophoresis 30(21), 3757 – 3763.
Ganzera, M., Sturm, S., Stuppner, H. (2009): Plant analysis – state of the art and future developments. Planta Medica 75(7), 671 – 671.
Gumy, C., Thurnbichler, C., Aubry, E.M., Balasz, Z., Pfisterer, P., Baumgartner, L., Stuppner, H., Odermatt, A., Rollinger, J.M. (2009): Inhibition of 11β-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia 80(3), 200 – 205.
Horak, SB., Koschak, A., Stuppner, H., Striessnig, J. (2009): Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers. Journal of Pharmacology and Experimental Therapeutics 330(1), 220 – 226.
Pieri V., Schwaiger, S., Ellmerer, E.P., Stuppner, H. (2009): Iridoid Glycosides from the Leaves of Sambucus ebulus. Journal of Natural Products 72(10), 1798 – 1803.
Reisinger, U., Schwaiger, S., Zeller, I., Messner, B., Stigler, R., Wiedemann, D., Mayr, T., Seger C., Schachner, T., Dirsch, V.M., Vollmar, A.M., Bonatti, J.O., Stuppner H., Laufer G., Bernhard, D. (2009): Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts. Cardiovascular research 82(3), 542 – 549.
Rinner, B., Li Zeng, X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., Pfragner, R. (2009): Antiproliferative and Pro-apoptotic Effects of Uncaria tomentosa in Human Medullary Thyroid Carcinoma Cells. Anticancer Research 29(11), 4519 – 4528.
Rollinger, J.M., Schuster, D., Danzl, B., Schwaiger, S., Markt, P., Schmidtke, M., Gertsch, J., Raduner, S., Wolber, G., Langer, T., Stuppner, H. (2009): In silico Target Fishing for Rationalized Ligand Discovery Exemplified on Constituents of Ruta graveolens. Planta Medica 75(3), 195 – 204.
Assimopoulou A.N., Ganzera, M., Stuppner, H., Papageorgiou, V.P. (2008): Simultaneous determination of monomeric and oligomeric alkannins and shikonins by high-performance liquid chromatography-diode array detection-mass spectrometry. Biomedical Chromatography 22(2), 173 – 190
Citova, I., Ganzera, M., Stuppner, H., Solich, P. (2008): Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. Journal of Separation Science 31(1), 195 – 200.
Ganzera, M., Egger, C., Zidorn, C., Stuppner, H. (2008): Quantitative analysis of flavonoids and phenolic acids in Arnica montana L. by micellar electrokinetic capillary chromatography. Analytica Chimica Acta 614(2), 196 – 200.
Ganzera, M., Guggenberger, M., Stuppner, H., Zidorn, C. (2008): Altitudinal variation of secondary metabolite profiles in flowering heads of Matricaria chamomilla cv. BONA. Planta Medica 74(7), 453 – 457.
Hornick, A., Schwaiger, S., Rollinger, J.M., Phung Vo, N., Prast, H., Stuppner, H. (2008): Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties. Biochemical Pharmacology 76(2), 236 – 248.
Li, Z.X., Sturm, S., Svejda, B., Höger, H., Schraml, E., Ingolic, E., Siegl, V., Stuppner, H., Pfragner, R. (2008): Anticancer Activity of Novel Extracts from Cautleya gracilis (Smith) Dandy: Apoptosis in Human Medullary Thyroid Carcinoma Cells. Anticancer Research 28(5), 2705 – 2713.
Nguyen, T.H.H., Nguyen, K.Q.T., Trinh, V.Q., Ganzera, M., Stuppner, H. (2008): Contribution to the study on phenylethanoid glycosides of the plant Jasminum subtriplinerve Blume. Tap chi Duoc hoc 48(2), 36 – 39.
Nguyen, T.H.H., Nguyen, K.Q.C., Trinh, V.Q., Zidorn, C., Ganzera, M., Stuppner, H. (2008): A new phenylpropanoid glycoside from Jasminum subtriplinerve Blume. Journal of Asian Natural Products Research 10(11), 1035 – 1038.
Paramapojn, S., Ganzera, M., Gritsanapan, W., Stuppner, H. (2008): Analysis of naphthoquinone derivatives in the Asian medicinal plant Eleutherine americana by RP-HPLC and LC-MS. Journal of Pharmaceutical and Biomedical Analysis 47(4-5), 990 – 993.
Rollinger J. M., Steindl, T. M., Schuster, D., Kirchmair, J., Anrain, K., Ellmerer, E. P., Langer, T., Stuppner, H., Wutzler P., Schmidtke, M. (2008): Structure-based virtual screening for the discovery of natural inhibitors for human rhinovirus coat protein. Journal of Medicinal Chemistry 51(4), 842 – 851.
Spitaler, R., Winkler, A., Lins, I., Yanar, S., Stuppner, H., Zidorn, C. (2008): Altitudinal Variation of Phenolic Contents in Flowering Heads of Arnica montana cv. ARBO: a 3-Year Comparison. Journal of Chemical Ecology 34(3), 369 – 375.
Sturm, S., Schinnerl, J., Greger, H., Stuppner, H. (2008): Nonaqueous capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry analysis of pyrrolo- and pyrido[1,2-a]azepine alkaloids in Stemona. Electrophoresis 29(10), 2079 – 2087.
Waltenberger, B, Avula, B., Ganzera, M., Khan, I.A., Stuppner, H., Khan, S.I. (2008): Transport sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers – an in vitro model for intestinal absorption. Phytomedicine 15(5), 373 – 377.
Zidorn, C., Schubert, B., Stuppner, H. (2008): Phenolics as Chemosystematic Markers in and for the Genus Crepis (Asteraceae, Cichorieae). Scientia Pharmaceutica 76(4), 743 – 750.
Aberham, A., Schwaiger, S., Stuppner, H., Ganzera, M. (2007): Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. Journal of Pharmaceutical and Biomedical Analysis 45(3), 427 – 442.
Li, Zengxia., Sturm, S., Stuppner, H., Schraml, E., Moser, V. A., Siegl, V., Pfragner, R. (2007): The dichloromethane fraction of Stemona tuberosa Lour inhibits tumor cell growth and induces apoptosis of human medullary thyroid carcinoma cells. Biologics: Targets & Therapy 1(4), 455 – 463.
Pekin, G., Ganzera, M., Senol, S., Bedir, E., Korkmaz K., S; Stuppner, H. (2007): Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography. Planta Medica 73(3), 267 - 272.
Sari, A., Zidorn, C., Ellmerer, E. P., Ozgokce, F., Ongania, K. H., Stuppner, H. (2007): Phenolic compounds from Scorzonera tomentosa L.. Helvetica Chimica Acta 90(2), 311 - 317.
Schmieder, A., Schwaiger, S., Csordas, A., Backovic, A., Messner, B., Wick, G., Stuppner, H., Bernhard, D. (2007): Isogentisin - A novel compound for the prevention of smoking-caused endothelial injury. Atherosclerosis 194(2), 317 - 325.
Speroni, E., Cervelatti, R., Costa, S., Guerra, M.C., Utan, A., Govoni, P., Berger, A., Müller, A., Stuppner, H. (2007): Effects of Differential Extraction of Verbena officinalis on Rat Models of Inflammation, Cicatrization and Gastric Damage. Planta Medica 73(3), 227 – 235.
Sturm, S., Seger, C., Godejohann, M., Spraul, M., Stuppner, H. (2007): Conventional sample enrichment strategies combined with high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance analysis allows analyte identification from a single minuscule Corydalis solida plant tuber. Journal of Chromatography A, 1163(1-2), 138 - 144.
Sturm, S., Seger, C., Stuppner, H. (2007): Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry. Journal of Chromatography A, 1159(1-2), 42 - 50.
Zidorn, C., Ellmerer, E. P., Heller, W., Joehrer, K., Frommberger, M., Greil, R., Guggenberger, M., Ongania, K. H., Stuppner, H. (2007): A new sesquiterpene lactone sulfate from Reichardia gaditana (Asteraceae). Zeitschrift fuer Naturforschung, B: Chemical Sciences 62b, 132 - 134.
Zidorn C., Ellmerer, E.P., Schwingshackl, E., Ongania, K.H., Stuppner, H. (2007): An unusual sesquiterpenoid from Hypochaeris achyrophorus (Astereaceae). Natural Product Research 21(13), 1165 – 1170.
Zidorn, C., Spitaler, R., Grass, S., Mader, J., Mueller, T., Ellmerer, E. P., Stuppner, H. (2007): Four new hypocretenolides (guaian-12,5-olides) from Leontodon rosani (Asteraceae, Cichorieae). Biochemical Systematics and Ecology 35(5), 301 - 307.
Bacher, N., Tiefenthaler, M., Sturm, S., Stuppner, H., Ausserlechner, M. J., Kofler, R., Konwalinka, G. (2006): Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. British Journal of Haematology 132(5), 615 - 622.
Ganzera, M., Aberham, A., Stuppner, H. (2006): Development and Validation of an HPLC/UV/MS Method for Simultaneous Determination of 18 Preservatives in Grapefruit Seed Extract. Journal of Agricultural and Food Chemistry 54(11), 3768 - 3772.
Ganzera, M., Schneider, P., Stuppner, H. (2006): Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sciences 78(8), 856 - 861.
Ganzera, M.; Vrabl, P.; Wörle, E.; Burgstaller, W.; Stuppner, H. (2006): Determination of adenine and pyridine nucleotides in glucose-limited chemostat cultures of Penicillium simplicissimum by one-step ethanol extraction and ion-pairing liquid chromatography. Analytical Biochemistry 359(1), 132 – 140.
Grass, S., Zidorn, Christian, Blattner, F. R., Stuppner, H. (2006): Comparative molecular and phytochemical investigaton of Leontodon autumnalis (Asteraceae, Lactuceae) populations from Central Europe. Phytochemistry 67(2), 122 – 131.
Mueller, A., Ganzera, M., Stuppner, H. (2006): Analysis of phenolic glycosides and saponins in Primula elatior and Primula veris (primula root) by liquid chromatography, evaporative light scattering detection and mass spectrometry. Journal of Chromatography A 1112, 218 - 223.
Rollinger J.M., Schuster D., Baier E., Ellmerer E.P., Langer T., Stuppner, H. (2006): Taspine: Bioactivity-Guided Isolation and Molecular Ligand-Target Insight of a Potent Acetylcholinesterase Inhibitor from Magnolia x soulangiana. Journal of Natural Products 69(9), 1341 - 1346.
Rollinger, J. M., Spitaler, R., Menz, M., Marschall, K., Ellmerer, E. P., Schneider, P., Stuppner, H. (2006): Venturia inaequalis inhibiting Diels-Alder-adducts from Morus root bark. Journal of Agricultural and Food Chemistry 54(22), 8432 – 8436.
Schwaiger, S., Seger, C., Wiesbauer, B., Schneider, P., Ellmerer, E. P., Sturm, S., Stuppner, H. (2006): Development of a HPLC-DAD/MS assay for the Identification and Quantification of major phenolic Edelweiss (Leontopodium alpinum Cass.) constituents. Phytochemical Analysis 17(5), 291 – 298.
Seger, C., Eberhart, K., Sturm, S., Strasser, H., Stuppner, H. (2006): Apolar chromatography on Sephadex LH-20 combined with high-speed counter-current chromatography. High yield strategy for structurally closely related analytes Destruxin derivatives from Metarhizium anisopliae as a case study. Journal of Chromatography A 1117(1), 67 - 73.
Seger, C., Godejohann, M., Spraul, M., Stuppner, H., Hadacek, F. (2006): Reaction product analysis by high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance Application to the absolute configuration determination of naturally occurring polyyne alcohols. Journal of Chromatography A 1136(1), 82 - 88.
Speroni, E., Schwaiger, S., Egger, P., Berger, A-T., Cervelatti, R., Govoni, P., Guerra, M. C., Stuppner, H. (2006): In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models. Journal of Ethnopharmacology 105(3), 421 – 426.
Spitaler, R., Schlorhaufer, P.D., Ellmerer, E. P., Merfort, I., Bortenschlager, S., Stuppner, H., Zidorn, C. (2006): Altitudinal variation of secondary metabolite profiles in flowering heads of Arnica montana cv. ARBO. Phytochemistry 67(4), 409 - 417.
Sturm, S., Strasser, E.-M., Stuppner, H. (2006): Quantification of Fumaria officinalis isoquinoline alkaloids by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry. Journal of Chromatography, A 1112(1-2), 331 - 338.
Zidorn, C., Grass, S., Ellmerer, E. P., Ongania, K.-H., Stuppner, H. (2006): Stilbenoids from Tragopogon orientalis. Phytochemistry 67(19), 2182 - 2188.
Zidorn, C., Horak, S., Weavers, R. T., Ellmerer, E. P., Stuppner, H., Van Klink, J.W. (2006): Diterpenoids and phenolics from Pseudopanax simplex. Journal of the Serbian Chemical Society 71(2), 121 - 125.
Zidorn, C., Pschorr, S., Ellmerer, E.P., Stuppner, H. (2006): Occurrence of equisetumpyrone and other phenolics in Leontodon crispus. Biochemical Systematics and Ecology 34(2), 185 - 187.
Zidorn, C., Spitaler, R., Ellmerer, E. P., Stuppner, H. (2006): On the occurrence of the guaianolide glucoside ixerin F in Chondrilla juncea and its chemosystematic significance. Biochemical Systematics and Ecology 34(12), 900 – 902.
Ganzera, M., Lanser, C.; Stuppner, H. (2005): Simultaneous determination of Ephedra sinica and Citrus aurantium var. amara alkaloids by ion-pair chromatography. Talanta 66(4), 889 - 894.
Ganzera, M., Orsi, H., Zidorn, C., Khan, I.A., Stuppner, H. (2005): Occurrence of grandifloroside-11-methyl ester in Nyssa ogeche (Nyssaceae). Biochemical Systematics and Ecology 33(3), 327 - 329.
Ganzera, M., Piereder, D., Sturm, S., Erdelmeier, C., Stuppner, H. (2005): Urtica dioica agglutinin: Separation, identification, and quantitation of individual isolectins by capillary electrophoresis and capillary electrophoresis-mass spectrometry. Electrophoresis 26(9), 1724 - 1731.
Ganzera, M., Poecher, A., Stuppner, H. (2005): Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS. Phytochemical Analysis 16(3), 205 - 209.
Le Claire, E.; Schwaiger, S., Banaigs, B.; Stuppner, H.; Gafner, F. (2005): Distribution of a New Rosmarinic Acid Derivative in Eryngium alpinum L. and Other Apiaceae. Journal of Agricultural and Food Chemistry 53(11), 4367 - 4372.
Rollinger, J. M., Bodensieck, A., Seger, C., Ellmerer, E. P., Bauer, R., Langer, T., Stuppner, H. (2005): Discovering COX-inhibiting constituents of Morus root bark: Activity-guided versus computer-aided methods. Planta Medica 71, 399 - 405.
Rollinger, J.M., Ewelt, J., Seger, C., Sturm, S., Ellmerer, E.P., Stuppner, H. (2005): New Insights into the Acetylcholinesterase Inhibitory Activity of Lycopodium clavatum. Planta Medica 71, 1040 – 1043.
Rollinger, J.M., Mock, P., Zidorn, C., Ellmerer, E.P., Langer, T., Stuppner, H. (2005): Application of the in combo screening approach for the discovering of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Current Drug Discovery Technologies, 2(3), 185 – 193.
Schwaiger, S., Cervellati, R., Seger, C., Ellmerer, E. P., About, N., Renimel, I., Godenir, C., André, P., Stuppner, H. (2005): Leontopodic acid – a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties. Tetrahedron 61(19), 4621 – 4630.
Seger, C., Erlebach, D., Stuppner, H., Griesser, U. J., Strasser, H. (2005): Physico-chemical properties of oosporein, the major secreted metabolite of the entomopathogenic fungus Beauveria brongniartii. Helvetica Chim. Acta 88(4), 802 – 810.
Seger, C.; Godejohann, M., Tseng, L.-H., Spraul, M., Girtler, A., Sturm, S., Stuppner, H. (2005): LC-DAD-MS/SPE-NMR Hyphenation. A Tool for the Analysis of Pharmaceutically Used Plant Extracts: Identification of Isobaric Iridoid Glycoside Regioisomers from Harpagophytum procumbens. Analytical Chemistry 77(3), 878 - 885.
Seger, C., Laengle, T., Pernfuss, B., Stuppner, H., Strasser, H. (2005): High-performance liquid chromatography-diode array detection assay for the detection and quantification of the Beauveria metabolite oosporein from potato tubers. Journal of Chromatography A 1092(2), 254 - 257.
Seger, C., Sturm, S., Haslinger, E., Stuppner, H. (2005): NMR Signal Assignment of 22-Deoxocucurbitacin D and Cucurbitacin D from Ecballium elaterium L. (Cucurbitaceae). Monatshefte für Chemie 136(9), 1645 - 1649.
Seger, C., Sturm, S., Laengle, T., Wimmer, W., Stuppner, H., Strasser, H. (2005): Development of a Sensitive High-Performance Liquid Chromatography-Diode Array Detection Assay for the Detection and Quantification of the Beauveria Metabolite Oosporein from Submerged Culture Broth and Bio-Control Formulations. Journal of Agricultural and Food Chemistry 53(5),1364 -1369.
Seger, C, Sturm, S., Mair, M.E., Ellmerer, E.P., Stuppner, H. (2005): 1H and 13C NMR signal assignment of cucurbitacin derivatives from Citrullus colocynthis (L.) Schrader and Ecballium elaterium L. (Cucurbitaceae).Magnetic Resonance in Chemistry 43(6), 489 - 491.
Zidorn, C., Ellmerer, E. P., Konwalinka, G., Ongania, K.-H., Schwaha, R., Greil, R., Joehrer, K., Perry, N. B., Stuppner, H. (2005): 1,10-epoxyhypocretenolides from the Azorean endemic Leontodon rigens (Asteraceae). Letters in Organic Chemistry 2(5), 461 - 464.
Zidorn, C.; Joehrer, K.; Ganzera, M.; Schubert, B.; Sigmund, E. M.; Mader, J.; Greil, R.; Ellmerer, E. P.; Stuppner, H. (2005): Polyacetylenes from the Apiaceae Vegetables Carrot, Celery, Fennel, Parsley, and Parsnip and Their Cytotoxic Activities. Journal of Agricultural and Food Chemistry 53(7), 2518 - 2523.
Zidorn, C., Lohwasser, U., Pschorr, S., Salvenmoser, D., Ongania, K.-H., Ellmerer, E. P., Boerner, A., Stuppner, H. (2005): Bibenzyls and dihydroisocoumarins from white salsify (Tragopogon porrifolius subsp. porrifolius). Phytochemistry 66(14), 1691 - 1697.
Zidorn, C., Petersen, B.O., Udovicic, V., Larsen, T.O., Duus, J.O., Rollinger, J.M., Ongania, K.H., Ellmerer, E.P., Stuppner, H. (2005): Podospermic acid, 1,3,5-tri-O-(7,8-dihydrocaffeoyl)quinic acid from Podospermum laciniatum (Asteraceae). Tetrahedron Letters 46(8), 1291 - 1294.
Zidorn, C., Schubert, B., Stuppner, H. (2005): Altitudinal differences in the contents of phenolics in flowering heads of three members of the tribe Lactuceae (Asteraceae) occurring as introduced species in New Zealand. Biochemical Systematics and Ecology 33(9), 855 - 872.
Zidorn, C., Schwaha, R. E., Ellmerer, E. P., Stuppner, H. (2005): On the occurrence of Sonchuside A in Cicerbita alpina and its chemosystematic significance. Journal of the Serbian Chemical Society 70(2), 171 - 175.
Zidorn, C., Udovicic, V., Spitaler, R., Ellmerer, E. P., Stuppner, H. (2005): Secondary metabolites from Arnoseris minima. Biochemical Systematics and Ecology 33(8), 827 - 829.
Patentanmeldungen / Patent applications
Rollinger, J. M.; Prast, H., Schuster, D.; Langer, T.; Hornick, A.; Stuppner, H. (2010): Morphinan-6-one compounds for the treatment or prevention of neurodegenerative diseases. EP 09015938.5, 44pp.
Stuppner, H., Schwaiger, S., Bernhard, D., Laufer, G. (2010): Pharmaceutical compositions comprising lignans from Edelweiss and their derivatives for treating hyperlastic diseases. WO2010007169 A1.
Schyschka, L.; Vollmar, A.; Barth, N.; Stuppner, H.; Langer, T.; Rollinger, J; Bliem, C. (2009): Non-peptidic promoters of apoptosis. WO2009065570 A1.
Prast, H.; Rollinger, J. M.; Schwaiger, S.; Stuppner, H. (2007): Use of extracts and constituents of Leontopodium as enhancers of cholinergic function. WO2007006492 A1.
Stuppner, H., Langer, T., Prast, H., Rollinger, J. M., Wolber, G., (2005): Use of coumarin derivatives. EP1588705 A1.
Curriculum vitae
1976-1982 Study of Pharmaceutical Sciences, University Innsbruck, Austria
April 1983 Licensed as a qualified pharmacist in Italy
1982 - 1985 Ph.D., Institute of Pharmaceutical Biology, University Munich, Germany
1986-1987 Postdoc at the Department of Developmental and Cell Biology, Phytochemical & Toxicology
Laboratory, University of California, USA
1993 Habilitation at the Institute of Pharmacognosy, University Innsbruck, Austria
1987 – 1997 Employment as Scientific Assistant at the Institute of Pharmacognosy, University Innsbruck
1995 Call for a C-3 Professor Position “Pharmazeutische Biologie” at the University Marburg,
Germany
1997 Assoc. Professor of Pharmacognosy at the University Innsbruck, Austria
since 2001 Full Professor of Pharmacognosy (Pharmaceutical Biology) and Head of the Institute of
Pharmacy at the University Innsbruck, Austria